Poor cardiorespiratory fitness may be an indicator of more severe liver inflammation in non-alcoholic fatty liver disease patients - 11/08/23
Highlights |
• | Liver inflammation may be a mechanism of very poor/poor fitness in non-alcoholic fatty liver disease patients. |
• | According to this study, non-alcoholic steatohepatitis and sedentarism were independently associated with very poor/poor cardiorespiratory fitness. |
• | This study provides evidence that there is no correlation between VO2max determined by the ergometric test and the six-minute walk test. |
Abstract |
Introduction |
Non-alcoholic fatty liver disease (NAFLD) is related to cardiovascular disease. Cardiorespiratory fitness (CRF) is an important indicator of cardiovascular health. Therefore, we aimed to evaluate the CRF of NAFLD patients.
Methods |
Cross-sectional study, including 32 patients with biopsy-proved NAFLD. The patients underwent ergometric test (ET) and six-minute walk test (6MWT) to determine CRF. The test results were compared to disease parameters and with each other.
Results |
Considering the ET, 20 (62.5%) patients had very poor or poor CRF, and in 12 (37.5%), it was regular or good. In the 6MWT, 13 (40.6%) individuals had poor CRF, in 12 (37.5%), it was very poor, and in seven (21.9%), regular. NAFLD activity score (NAS) ≥5 was observed in 12 (37.5%) individuals. Twelve (37.5%) patients were sedentary, 11 (34.4%), insufficiently active, and nine (28.1%), active. Obesity and liver inflammation on biopsy were associated with very poor/poor CRF. NAS ≥5 and sedentary lifestyle were independently associated with very poor/poor CRF by ET. Although mean VO2max values determined by both tests were similar, no correlation of VO2max determined by ET and 6MWT was observed, as occurred for the distance walked in 6MWT and values of metabolic equivalent (MET) determined by ET. There was no reproducibility between CRF determined by ET and 6MWT.
Conclusion |
Most NAFLD patients had very poor or poor CRF. Severe liver injury (NAS ≥5) and sedentary lifestyle were independently associated with very poor/poor fitness, according to ET. No reproducibility was observed between the CRF defined by ET and 6MWT.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Non-alcoholic fatty liver disease, Ergometric test, 6-minute walk test, Physical fitness, Cardiorespiratory fitness
Abbreviations : NAFLD, CRF, ET, 6MWT, NASH, VO2max, TG, HDL, AC, BMI, SPO2, IPAQ, MET, MS, SD, IQR
Mappa
Vol 47 - N° 7
Articolo 102163- Agosto 2023 Ritorno al numero
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