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Evaluation of Huawei smart wearables for detection of atrial fibrillation in patients following ischemic stroke: The Liverpool-Huawei stroke study - 10/02/23

Doi : 10.1016/j.ahj.2022.12.004 
Stephanie L. Harrison, PhD a, b, , Benjamin J.R. Buckley, PhD a, b, c, Yalin Zheng, PhD a, d, Andrew Hill, MBChB, MSc a, e, Thant Hlaing, MBChB a, f, Ruth Davies, MBChB g, Yutao Guo, PhD a, h, Deirdre A. Lane, PhD a, b, i, #, Gregory Y.H. Lip, MD a, b, c, i, #,
on behalf of the

Liverpool-Huawei Stroke Study Investigatorsa, b, c, j, k, l, m, n, o,

  Liverpool-Huawei Stroke Study Investigators: Sylvia Choia,j, Sandra Elsheikha,j, Dimitrios Sagrisa,k, Martha Joddrella,b, Muath Alobaidaa,b,l, Elizabeth McCarthyc,m, Ian Eustacec,m, Katie Hoadc, Sunil Jit R.J. Loganthaa,b, Garry McDowella,c,n, Alena Shantsilaa,b, Ying Guea,b, Masoud Isanejado, Ian Jonesc,m
Sylvia Choi a, j, Sandra Elsheikh a, j, Dimitrios Sagris a, k, Martha Joddrell a, b, Muath Alobaida a, b, l, E. McCarthy c, Elizabeth McCarthy i, m, I. Eustace c, Ian Eustace i, m, K. Hoad c, S.J. Katie Hoad i, Sunil Jit R.J. Logantha a, b, Garry McDowell a, c, n, Alena Shantsila a, b, Ying Gue a, b, M Isanejad o, I. Jones c, Masoud Isanejad o, Ian Jones i, m
a Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, United Kingdom 
b Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom 
c Liverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, United Kingdom 
i Department of Clinical Medicine, Aalborg University, Aalborg, Denmark 
j Department of Cardiology, Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Foundation Trust, Merseyside, United Kingdom 
k Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece 
l Department of Basic Science, Prince Sultan Bin Abdulaziz College for Emergency Medical Services, King Saud University, Riyadh, Saudi Arabia 
m School of Nursing and Allied Health, Liverpool John Moores University, Liverpool, United Kingdom 
n School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom 
o Institute of Life Course and Medical Sciences, Department of Musculoskeletal and Ageing Sciences, University of Liverpool, Liverpool, United Kingdom 

a Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, United Kingdom 
b Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom 
c Liverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, United Kingdom 
d Department of Eye and Vision Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom 
e Department of Medicine for Older People, Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Foundation Trust, Merseyside, United Kingdom 
f Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Merseyside, United Kingdom 
g Arrowe Park Hospital, Wirral University Teaching Hospital NHS Trust, Merseyside, United Kingdom 
h Department of Pulmonary Vessel and Thrombotic Disease, Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China 
i Department of Clinical Medicine, Aalborg University, Aalborg, Denmark 
j Department of Cardiology, Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Foundation Trust, Merseyside, United Kingdom 
k Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Thessaly, Greece 
l Department of Basic Science, Prince Sultan Bin Abdulaziz College for Emergency Medical Services, King Saud University, Riyadh, Saudi Arabia 
m School of Nursing and Allied Health, Liverpool John Moores University, Liverpool, United Kingdom 
n School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom 
o Institute of Life Course and Medical Sciences, Department of Musculoskeletal and Ageing Sciences, University of Liverpool, Liverpool, United Kingdom 

Reprint requests: Stephanie L. Harrison, Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, L7 8TX United Kingdom.Liverpool Centre for Cardiovascular ScienceUniversity of LiverpoolLiverpoolL7 8TXUnited Kingdom.⁎⁎Reprint requests: Gregory Y.H. Lip, Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.,Department of Cardiovascular and Metabolic MedicineInstitute of Life Course and Medical SciencesUniversity of LiverpoolLiverpoolUnited Kingdom.

Riassunto

Background

Atrial fibrillation (AF) often remains undetected following stroke. Documenting AF is critical to initiate oral anticoagulation, which has proven benefit in reducing recurrent stroke and mortality in patients with AF. The accuracy and acceptability of using smart wearables to detect AF in patients following stroke is unknown.

Methods

The aims of the Liverpool-Huawei Stroke Study are to determine the effectiveness, cost-effectiveness and patient and staff acceptability of using Huawei smart wearables to detect AF following ischemic stroke. The study plans to recruit 1,000 adults aged ≥18 years following ischemic stroke from participating hospitals over 12 months. All participants will be asked to wear a Huawei smart band for 4 weeks postdischarge. If participants do not have access to a compatible smartphone required for the study, they will be provided with a smartphone for the 4-week AF monitoring period.

Results

Participants with suspected AF detected by the smart wearables, without previous known AF, will be referred for further evaluation. To determine the effectiveness of the Huawei smart wearables to detect AF, the positive predictive value will be determined. Patient acceptability of using this technology will also be examined. Additional follow-up assessments will be conducted at 6 and 12 months, and clinical outcomes recorded in relation to prevalent and incident AF post-stroke. The study opened for recruitment on May 30, 2022, and is currently open at 4 participating hospitals; the first 106 participants have been recruited. One further hospital is preparing to open for recruitment.

Conclusions

This prospective study will examine the effectiveness and acceptability of the use of smart wearables in patients following ischemic stroke. This could have important implications for detection of AF and therefore, earlier prophylaxis for recurrent stroke. The study is registered on www.isrctn.com/ (Identifier ISRCTN30693819).

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