Efficacy And Safety Of Bradykinin B2 Receptor Inhibition With Oral PHVS416 In Treating Hereditary Angioedema Attacks: Results Of RAPIDe-1 Phase 2 Trial - 03/02/23
Doi : 10.1016/j.jaci.2022.12.419
Marcus Maurer, MD 1, John Anderson, MD, FAAAAI 2, Emel Aygören-Pürsün, MD 3, Laurence Bouillet, MD PhD 4, María Luisa Baeza 5, Hugo Chapdelaine, MD 6, Danny Cohn, MD PhD 7, Aurélie Du-Thanh, MD, PhD 8, Olivier Fain, MD 9, Henriette Farkas, MD PhD DSc 10, Jens Greve, MD 11, Mar Guilarte, MD, PhD 12, David Hagin, MD 13, Roman Hakl, MD, PhD 14, Joshua Jacobs, MD 15, Aharon Kessell, MD 16, Sorena Kiani-Alikhan, MBPhD 17, Pavlína Králíčková, MD, PhD 18, Huamin Li, MD PhD FAAAAI 19, Ramon Lleonart Bellfill, MD 20, Markus Magerl, MD PhD 1, Michael Manning, MD, FAAAAI 21, Avner Reshef, MD 22, Bruce Ritchie, MD 23, Giuseppe Spadaro, MD 24, Maria Staevska, MD, PhD 25, Petra Staubach, MD 26, Marcin Stobiecki, MD 27, Gordon Sussman, MD FAAAAI 28, Michael Tarzi, MD 29, Anna Valerieva, MD, PhD 25, William Yang, MD 30, Marie-Helene Jouvin, MD 31, Rafael Crabbé, MD 32, Simone van Leeuwen 33, Huaihou Chen, PhD 31, Li Zhu, PhD 31, Jochen Knolle, PhD 34, Anne Lesage, PhD 34, Peng Lu, MD, PhD 31, Marc Riedl, MD MS 35
1 Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
2 Clinical Research Center of Alabama, AllerVie Health Birmingham, AL, USA
3 Department for Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany
4 National Reference Center for Angioedema (CREAK), Department of Internal Medicine, Grenoble Alpes University, Laboratoire T-RAIG, UMR 5525 TIMC-IMAG (UGA-CNRS), Grenoble, France
5 Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
6 CHU de Montréal, Université de Montréal, Montréal, Canada
7 Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
8 Department of Dermatology, University Montpellier, Montpellier, France
9 Department of Internal Medicine, Sorbonne University, AP-HP, Saint Antoine Hospital, Paris, France
10 Department of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary
11 Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany
12 Allergy Section, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
13 Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel
14 Department of Clinical Immunology and Allergology, St. Anne's University Hospital in Brno, Brno, Czech Republic
15 Allergy and Asthma Clinical Research, Walnut Creek, CA, USA
16 Bnai Zion Medical Center, Technion-Israel Institute of Technology, Haifa, Israel
17 Department of Immunology, Barts Health NHS Trust, London, United Kingdom
18 Institute of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
19 Institute for Asthma and Allergy, Chevy Chase, MD, USA
20 Allergology Service, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain
21 Allergy, Asthma and Immunology Associates, Ltd., Scottsdale, Arizona
22 Allergy, Immunology and Angioedema Center, Barzilai University Hospital, Ashkelon, Israel
23 Division of Hematology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
24 Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Napoli, Italy
25 Department of Allergology, Clinic of Allergology, University Hospital “Alexandrovska”, Medical University of Sofia, Sofia, Bulgaria
26 Department of Dermatology, University Medicine Mainz, Mainz, Germany
27 Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland
28 Gordon Sussman Clinical Research Inc, Toronto, Canada
29 Department of Medicine, Brighton and Sussex Medical School, Brighton, UK
30 Ottawa Allergy Research Corporation, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
31 Pharvaris Inc., Lexington, MA, USA
32 RC Consultancy, Bassins, Switzerland
33 SLC Consultancy, Woerden, The Netherlands
34 Pharvaris GmbH, Zug, Switzerland
35 Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
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© 2022
Pubblicato da Elsevier Masson SAS.
Vol 151 - N° 2S
P. AB134 - Febbraio 2023 Ritorno al numero
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