Preparation of small bowel capsule endoscopy (SBCE) with simethicone: A meta-analysis - 24/11/22
Highlights |
• | Simethicone did not improve diagnostic yield or completion rate in small bowel capsule endoscopy but did improve the visualization and reduce the gas bubbling of small bowel capsule endoscopy. Although simethicone improves the visualization quality of the small bowel, the dose of simethicone remains unclear. So, more studies are needed in the future to investigate its dose to achieve optimal bowel preparation. |
Abstract |
Background |
It is disputed about optimal bowel preparation for small bowel capsule endoscopy (SBCE). This meta-analysis aimed to investigate the role of simethicone in intestinal preparation for SBCE.
Methods |
We searched four databases (PubMed, web of science, Embase, and Scopus databases) for relevant studies. Studies evaluating the effect of simethicone as an adjunct to SBCE bowel preparation were included. The random-effects model was applied to calculate the risk estimates. Primary outcomes include the degree of gas bubbles and small bowel visualization quality (SBVQ). Secondary outcomes include diagnostic yield (DY), gastric transit time (GTT), small bowel transit time (SBTT), and completion rate (CR).
Results |
A total of 10 studies were included (8 RCTs, 1 prospective, and 1 retrospective study). Compared with the control group, the simethicone group showed significant improvements in the degree of gas bubbling (RR = 2.05, 95%CI:1.56-2.71, P < 0.001, I2 = 62%) and SBVQ (RR = 1.41, 95%CI: 1.20-1.65, P < 0.001, I2 = 16%). Subgroup analysis showed that the SBVQ of simethicone group was better than fasting (RR = 2.62, 95% CI:1.49–4.59, P < 0.001, I2 = 0%), mannitol (RR = 1.35, 95% CI: 1.14-1.59, P < 0.001, I2 = 0%) and PEG group (RR = 1.32, 95%CI:1.06-1.65, P = 0.01, I2 = 0%). No significant associations were found for DY, GTT, SBTT, and CR.
Conclusions |
Simethicone for bowel preparation is useful to improve visualization and reduce the gas bubbling of SBCE.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Simethicone, Bowel preparation, SBCE, Anti-foaming agent, Capsule endoscopy
Abbreviations : SBCE, SBVQ, DY, GTT, SBTT, CR, RCT, RR, CI, SD, MD, SMD
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Vol 46 - N° 10
Articolo 102029- Dicembre 2022 Ritorno al numero
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