Effects of elevated bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy, a retrospective study from a neonatal perspective - 01/10/22
, Weiwei Lun, Wei ShiHighlight |
• | The high concentration of bile acid in ICP patients is harmful to fetus mainly reflected in the myocardial damage of bile acid to fetus. |
• | Cardiac dysfunction of 1-day-old neonates is associated with elevated bile acid levels in intrahepatic cholestasis of pregnancy. |
• | Fetal cardiotoxicity of high bile acid concentration may be one of the causes of ICP stillbirth,since left ventricular fraction shortening(FS) is significantly decressed in 1-day-old ICP neonates . |
• | After being removed from high bile acid concentration, the cardiotoxicity of neonates could recover quickly. |
Abstract |
Aim |
Intrahepatic cholestasis of pregnancy (ICP) is a liver disease which may lead to a sudden fetal death.Previous studies have suggested that the fetal accident may be related to their cardiac dysfunction.However,the relationship between fetal cardiac dysfunction and their maternal bile acid levels is not clear.This objective was to clarify the relationship from a neonatal perspective and to furtherly make clear the aftereffect by analyzing the cardiac parameters of the older neonates.
Methods |
In this case-control study,patients and their neonates,managed between 10 September 2018 and 30 June 2021 at a Chinese university hospital center,were divided into severe ICP group,mild ICP group and control gestational group.The maternal bile acid levels and the cardiac paramerers of one-day-old neonates and five-day-old neonates were analyzed,respectively.
Results |
The specific-myocardial enzyme(CK-MB) and left ventricular fraction shortening(FS) of neonates showed significant difference between ICP group and control group, and were meaningfully correlated with maternal bile acid levels.However,There was no significant difference in cardiac injury parameters of older neonates between the ICP group and control group.
Conclusions |
The elevated maternal bile acid levels can lead to fetal myocardial injury and the injury can be recovered after removel from high concentrations of bile acid.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Intrahepatic cholestasis of pregnancy, Cardiac dysfunction
Abbreviations : ICP, TSBA, ALT, ECG, EF, FS, PR, QRS and QTc, LDH, HBDB, CK, CK-MB, UCG
Mappa
Vol 46 - N° 8
Articolo 102013- Ottobre 2022 Ritorno al numero
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