Diagnostic accuracy of apparent diffusion coefficient values combined with γ-glutamyl transpeptidase-to-platelet ratio parameters for predicting hepatitis B-related fibrosis - 01/10/22
, Feng Li d, ⁎ Highlights |
• | Apparent diffusion coefficient value was inversely associated with liver fibrosis. |
• | Apparent diffusion coefficient values shows potential to predict liver fibrosis. |
• | The combined diagnostic tool may improve the accuracy of liver fibrosis diagnosis. |
Abstract |
Objectives |
The accuracy of non-invasive liver fibrosis diagnosis based on the apparent diffusion coefficient (ADC) value combined with the γ-glutamyl transpeptidase-to-platelet ratio (GPR) model to predict the stage of hepatitis B-related fibrosis has not been reported. This study aimed to evaluate the diagnostic efficacy of ADC value combined with GPR for liver fibrosis grading.
Methods |
The data of 180 patients with chronic hepatitis B (CHB) diagnosed by liver biopsy were analyzed. The ADC value, GPR, and their combination were assessed in different cirrhosis stages using receiver operating characteristic curve analysis to evaluate their value in diagnosing liver fibrosis.
Results |
We observed that liver fibrosis stages were inversely associated with ADC values (r=−0.691, P<0.001), and positively associated with GPR (r=0.502, P<0.001). The area under the curve for diagnostic efficacy of ADC values, GPR, and their combination for F≥2 liver fibrosis was 0.831, 0.749, and 0.858, respectively, and for F≥3 was 0.872, 0.771, and 0.903, respectively. The diagnostic cutoffs of the combination for each stage were -7.07, -12.21 and -37.75, respectively.
Conclusions |
The combined diagnostic tool of ADC and GPR may improve the accuracy of hepatitis B-related liver fibrosis diagnosis, especially for F≥3.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Chronic hepatitis B, Liver fibrosis, Magnetic resonance spectroscopy, Apparent diffusion coefficient, γ-glutamyl transferase
Abbreviations : ADC, ALT, APRI, AST, AUC, CHB, DWI, GPR, MRI, NPV, PPV, ROC, ROI, γ-GT
Mappa
Vol 46 - N° 8
Articolo 101968- Ottobre 2022 Ritorno al numero
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