Chronic kidney disorder can be a prime health interest in Delta region, in particular Dakahlia district, Egypt that's characterized by permanent loss of kidney characteristic over time. Mercury considered as a silent threat to the environment and human life, through the world. This work purposes to access the effects of mercury overload in domestic water on the renal function.

The study performed in spring 2019 on one hundred participants and conducted in two main areas that are getting ready to Lake Manzala. 100mL of water, 40mL of urine and 10mL of blood samples from patients suffering from kidney diseases and healthy individuals as control group. These samples will be processed and analyzed to determine the extent of active kidney disease.

The mean levels of mercury in water, and urine samples of the case group exceeded the standard references and were significantly higher compared to the control group (P=0.0004 and 0.023 respectively) indicating more exposure to mercury. Proteinuria was significantly higher (P=0.031) whereas, hemoglobin and hematocrit became considerably decrease (P=0.039 and 0.044 respectively) among case group participants which is probably an indicator for kidney affection due to mercury exposure.

Mercury overload in domestic water can cause renal impairment. The study showed that urinalysis for Proteinuria and hemoglobin values is commonly used as a screening test to detect kidney damage caused by mercury poisoning. Measures to prevent environmental pollutants and continuous monitoring of water sources in these districts are clearly necessary.