The impact of metabolic health on non-alcoholic fatty liver disease (NAFLD). A single center experience - 10/06/22
Highlights |
• | Low percentage of NAFLD patients are metabolically healthy. |
• | Metabolically healthy NAFLD patients present a more propitious biochemical profile compared to metabolically unhealthy people. |
• | Metabolically non-healthy NAFLD patients do not present a significantly higher risk of liver disease compared to metabolically healthy patients. |
Abstract |
Background |
The role of patients’ metabolic clinical and biochemical profile in NAFLD has not been extensively explored.
Aims |
The aim of the study was to assess the role of metabolic health in NAFLD patients and to examine liver disease progression in these populations.
Methods |
The medical charts of 569 patients diagnosed with fatty liver were thoroughly reviewed; 344 patients were excluded because of other chronic liver diseases. Metabolically healthy people were defined as those who met none of the following criteria: blood pressure ≥ 130/85 mmHg or under hypertension treatment, fasting glucose ≥ 100 mg/dl or under diabetes treatment, serum triglycerides > 150 mg/dl, high density lipoprotein-cholesterol <40/50 mg/dl for men/women. Study participants were followed-up over a median period of 22 months.
Results |
The present observational case-control study included 225 NAFLD patients; 14 (6.2%) were metabolically healthy. Metabolically healthy participants were younger (p = 0.006), had lower age at diagnosis (p = 0.002), lower levels of γ-GT (p = 0.013), fasting glucose (p <0.001) and triglycerides (p <0.001) and higher HDL-cholesterol (p = 0.005) compared to metabolically non-healthy. By the last follow up assessment, 8 metabolically healthy patients had developed dyslipidemia; 1 patient (14.4%) had presented liver disease progression compared to 8 patients (10.5%) from the unhealthy group (p = 0.567). In multivariate analysis, diabetes mellitus (p = 0.017) and hemoglobin levels (p = 0.009) were the sole independent predictors of disease progression. No significant difference was observed in liver disease progression-free survival rates among the two patient groups (p = 0.503).
Conclusions |
Metabolically healthy NAFLD patients presented with a favorable biochemical profile; however, they were diagnosed with NAFLD at a younger age and the liver disease progression risk was similar to that of metabolically unhealthy patients. These findings suggest that metabolically healthy NAFLD may not constitute a benign condition and patients could potentially be at increased risk of metabolic syndrome and liver disease progression.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Metabolically healthy patients, Nonalcoholic fatty liver disease (NAFLD), Fatty liver, Metabolic syndrome (MetS), Liver disease
Abbreviations : NAFLD, NASH, T2DM, HCC, HBV, HCV, HIV, BMI, WC, HOMA-IR, SGOT, SGPT, ALP, γ-GT, HDL, LDL, INR, AFP, AASLD, WHO, IQR
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Vol 46 - N° 5
Articolo 101896- Maggio 2022 Ritorno al numero
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