Drug-eluting bead transarterial chemoembolization followed by apatinib is effective and safe in treating hepatocellular carcinoma patients with BCLC stage C - 27/03/22
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Highlights |
• | DEB-TACE plus apatinib achieves CR, ORR and DCR of 25.5%, 77.2% and 79.1%. |
• | DEB-TACE plus apatinib reaches 1-year PFS of 19.8% and 2-year PFS of 3.3%. |
• | DEB-TACE plus apatinib realizes 1-year OS of 66.5% and 3-year OS of 14.2%. |
• | Most AEs by DEB-TACE and apatinib are mild and well-tolerable. |
• | DEB-TACE plus apatinib is efficient and safe in BCLC stage C HCC patients. |
Abstract |
Background |
The present study aimed to evaluate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) followed by apatinib in treating hepatocellular carcinoma (HCC) patients with Barcelona Clinic Liver Cancer (BCLC) stage C.
Methods |
Totally, 110 HCC patients with BCLC stage C treated with DEB-TACE followed by apatinib were consecutively enrolled. Treatment response (including complete response rate (CR), objective response rate (ORR) and disease control rate (DCR)), survival data (progression-free survival (PFS), overall survival (OS)), and adverse events were documented during the follow-up.
Results |
CR, ORR and DCR were 25.5%, 77.2% and 79.1% at 3 months, then were 29.1%, 59.1% and 71.0% at 6 months, respectively. Regarding survival, median PFS (95%CI) was 6.3 (5.0-7.7) months, meanwhile 1-year and 2-year PFS were 19.8% and 3.3%, respectively; median OS (95%CI) was 16.9 (10.2-23.7) months, then 1-year, 2-year and 3-year OS were 66.5%, 34.7% and 14.2%, respectively. Further subgroup analysis indicated that nodule size, Child-Pugh stage, Eastern Cooperative Oncology Group performance status score and level of portal vein invasion were negatively correlated with PFS or OS, which were further validated by univariate and multivariate Cox's regression analysis. Most adverse events by DEB-TACE and apatinib treatment were mild and well-tolerable.
Conclusion |
DEB-TACE followed by apatinib is effective and safe in treating BCLC stage C HCC patients, indicating its role as an acceptable option in HCC management.
Il testo completo di questo articolo è disponibile in PDF.Keywords : DEB-TACE, Apatinib, Treatment response, Survival, Adverse events
Abbreviations : HCC, HBV, HCV, BCLC, OS, TACE, cTACE, DEB-TACE, HIF-1α, VEGFR, PDGF, ECOG PS, CT, MRI, mRECIST, CR, PR, SD, PD, ORR, DCR, PFS, IQR, SD
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Vol 46 - N° 3
Articolo 101859- Marzo 2022 Ritorno al numero
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