Association of shear-wave elastography with clinical outcomes post-liver transplantation - 28/10/21
, Olivier Lucidarme b, c, Elsa Mbarki a, b, Olivier Scatton d, e, Eric Savier d, e, Mathilde Wagner b, cBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Highlights |
• | Patients without complications post-transplantation had stiffer livers (mean 2D-SWE of 7.3kPa) than the general population. |
• | Mean±SD liver stiffness values on 2D SWE were significantly higher during the first 90 days post-transplantation than after the first year, respectively: 8.2±2.5 vs. 7.0±2.4kPa. |
• | Liver stiffness was more pronounced in patients with biliary complications during the first-year post-transplantation. |
Abstract |
Purpose |
Two-dimensional shear-wave elastography (2D-SWE) assessment of liver stiffness has the advantage of being obtained during conventional ultrasound. Liver-stiffness values on 2D-SWE for grafted livers are unknown, as are their potential link to post-transplantation morbidity. This study was undertaken to determine liver-stiffness values on 2D-SWE for grafted livers without complications, and examine relationships between liver-stiffness values on 2D-SWE and early post-operative arterial or biliary complications.
Methods |
In our facility, all liver-transplant recipients are entered in a comprehensive surgical database, where donor, procedure and recipient characteristics are described. All patients underwent systematic 2D-SWE assessment. Potential relationships were analyzed between liver-stiffness findings and donor, procedure and recipient characteristics, and follow-up events, including death, arterial or biliary complications, graft removal and allograft-dysfunction scores.
Results |
Liver-stiffness values on 2D-SWE of 337 ultrasound examinations from 165 liver-transplant recipients were collected retrospectively. Median time from transplantation to 2D-SWE examination was 149 days, with median follow-up at 36 months. The mean±SD stiffness value for grafts without complications was 7.3±2.3kPa; it was significantly higher during the first 90 days (8.2±2.5kPa) post-transplant than after 1year (7.0±2.4kPa) (P=0.01). Patients with biliary complications during the first-year post-transplantation had significantly higher mean liver-stiffness values on 2D-SWE than those without, respectively: 9.8±7.0 vs 7.5±1.8kPa (P=0.01).
Conclusions |
Post-transplantation patients without complications had stiffer livers than the general population, with higher values during the first 90 days after surgery. Liver-stiffness values on 2D-SWE were significantly higher for patients with biliary, but not arterial, complications.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : 2D-SWE, ET-DRI, IQR, MELD, SOFA
Keywords : Bile ducts, Elasticity imaging techniques, End-stage liver disease, Liver transplantation, Ultrasonography
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Vol 45 - N° 5
Articolo 101554- Settembre 2021 Ritorno al numero
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