Statins use and the prognosis of colorectal cancer: a meta-analysis - 28/10/21
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Highlights |
• | Statins use might be significantly associated with lower overall mortality in CRC. |
• | Statins use might be associated with lower cancer-specific mortality in CRC. |
• | Statin use was a protective factor for CRC prognosis. |
Abstract |
Background |
Previous observational studies regarding the prognostic value of statin on colorectal cancer (CRC) patients showed various results.
Methods |
Articles regarding the prognostic value of statin on CRC and published in English and before October 2020 were searched in the following databases: PubMed, Web of Science, EMBASE, Medline and Google Scholar. The multivariate hazard ratios (HRs) and their 95% confidence intervals (CI) were computed to explore associations between statins use and overall mortality or cancer-specific mortality of CRC.
Results |
The study included 5 retrospective case-control studies (including 475 statins users and 1925 no-statin users) and 11 prospective cohort studies (including 40659 statins users and 344459 no-statin users). The present study showed that statins use might be significantly associated with lower overall mortality in CRC with a random effects model (HR = 0.81, 95% CI 0.76 to 0.86, I2 = 61.9%, p value for Q test <0.001). In addition, statins use might be significantly associated with lower cancer-specific mortality in CRC with a random effects model (HR = 0.78, 95% CI 0.72 to 0.85, I2 = 57.3%, p value for Q test = 0.007).
Conclusions |
In conclusion, the present study indicated that that statin use was a protective factor for CRC prognosis. However, the relationship between statins use and CRC prognosis requires repeated and large prospective studies to be verified.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Colorectal cancer, Statin, Meta-analysis
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Vol 45 - N° 5
Articolo 101588- Settembre 2021 Ritorno al numero
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