Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity - 03/09/21
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Abstract |
Background |
In mid-December 2020, Israel started a nationwide mass vaccination campaign against coronavirus disease 2019 (COVID-19). In the first few weeks, medical personnel, elderly citizens, and patients with chronic diseases were prioritized. As such, patients with primary and secondary immunodeficiencies were encouraged to receive the vaccine. Although the efficacy of RNA-based COVID-19 vaccines has been demonstrated in the general population, little is known about their efficacy and safety in patients with inborn errors of immunity (IEI).
Objective |
Our aim was to evaluate the humoral and cellular immune response to COVID-19 vaccine in a cohort of patients with IEI.
Methods |
A total of 26 adult patients were enrolled, and plasma and peripheral blood mononuclear cells were collected from them 2 weeks following the second dose of Pfizer-BioNTech COVID-19 vaccine. Humoral response was evaluated by testing anti–SARS-CoV-2 spike (S) receptor-binding domain and antinucleocapsid antibody titers and evaluating neutralizing ability by inhibition of receptor-binding domain–angiotensin-converting enzyme 2 binding. Cellular immune response was evaluated by using ELISpot, estimating IL-2 and IFN-γ secretion in response to pooled SARS-CoV-2 S- or M-peptides.
Results |
Our cohort included 18 patients with a predominantly antibody deficiency, 2 with combined immunodeficiency, 3 with immune dysregulation, and 3 with other genetically defined diagnoses. Twenty-two of them were receiving immunoglobulin replacement therapy. Of the 26 patients, 18 developed specific antibody response, and 19 showed S-peptide–specific T-cell response. None of the patients reported significant adverse events.
Conclusion |
Vaccinating patients with IEI is safe, and most patients were able to develop vaccine-specific antibody response, S-protein–specific cellular response, or both.
Il testo completo di questo articolo è disponibile in PDF.Key words : Inborn errors of immunity, IEI, primary immunodeficiency disorders, PIDD, SARS-CoV-2, COVID-19, vaccine, Pfizer-BioNTech, CVID, XLA, NFKB1, STAT1-GOF, STAT3-LOF, HIES, inhibiting antibodies
Abbreviations used : ACE2, ALPS, anti-N, anti-S, AU, AUC, CID, COVID-19, CVID, IEI, IVIG, NF-κB1, NFKB1-HI, RBD, SARS-CoV-2, STAT, STAT1-GOF, XLA
Mappa
Supported by the Israel Science Foundation (grants 41222/18 and 3711/20 [to N.T.F.]), the Dahlia Greidinger Cancer Fund (to N.T.F.), a Marguerite Stolz Fellowship (N.T.F.), The Campbell Foundation for AIDS Research (to N.T.F.), and the Alrov Foundation (to D.H.). |
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Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 148 - N° 3
P. 739-749 - Settembre 2021 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.