Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review - 29/07/21
, Idrus Alwi, MD, Ph.D, FACC, FESC b, Raymond Pranata, MD c, Ian Huang, MD g, Michael Anthonius Lim, MD, MHSM c, Eddy Jose Gutierrez, MD d, Muhammad Yamin, MD, Ph.D b, Bambang Budi Siswanto, MD, Ph.D, FACC, FESC, FAsCC e, Salim S. Virani, MD, PhD, FACC, FAHA f
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Abstract |
Background |
Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease.
Purpose |
In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19.
Methods |
We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease.
Results |
We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001].
Conclusion |
Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Individuals with preexisting cardiovascular diseases are associated with poor outcomes with COVID 19. |
• | Decreased circulatory and physiological reserves in heart failure, are linked to a more severe course of the disease. |
• | Patients with Heart Failure are at increased risk for poor outcomes such as hospitalization, and death from COVID-19. |
• | Patients with heart failure have higher mortality rates compared to those without. |
Keywords : Coronavirus disease 2019, Heart failure, Poor outcomes
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Vol 46
P. 204-211 - Agosto 2021 Ritorno al numero
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