A deoxyribonuclease 1–like 3 genetic variant associates with asthma exacerbations - 04/03/21
Doi : 10.1016/j.jaci.2020.09.027
Esther Herrera-Luis, MSc a, Fabian Lorenzo-Diaz, PhD a, Lesly-Anne Samedy-Bates, PharmD, PhD b, c, Celeste Eng, BSc b, Jesús Villar, MD d, e, f, Jose R. Rodriguez-Santana, MD g, Esteban G. Burchard, MD, MPH b, c, Maria Pino-Yanes, PhD a, d, h 
a Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
b Department of Medicine, University of California San Francisco, San Francisco, Calif
c Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, Calif
d Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
e Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain
f Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada
g Centro de Neumología Pediátrica, San Juan, Puerto Rico
h Instituto de Tecnologías Biomédicas, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
| This study was funded by the Spanish Ministry of Science, Innovation and Universities (SAF2017-83417R), the State Research Agency, and the European Regional Development Fund from the European Union (MICIU/AEI/FEDER, UE). E.H.-L. was funded by a fellowship (PRE2018-083837) from the Spanish Ministry of Science, Innovation, and Universities. M.P.-Y. was supported by the Ramón y Cajal Program by the Spanish Ministry of Science, Innovation, and Universities (RYC-2015-17205). The Genes-Environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes and Environments (SAGE) were supported in part by the Sanler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, the Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II award, the National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL117004, R01HL128439, R01HL135156, 1X01HL134589, R01HL141992, and R01HL141845), the National Institute of Health and Environmental Health Sciences (R01ES015794 and R21ES24844), the National Institute on Minority Health and Health Disparities (P60MD006902, RL5GM118984, R01MD010443, and R56MD013312), the Tobacco-Related Disease Research Program (under awards 24RT-0025 and 27IR-0030), and the National Human Genome Research Institute (U01HG009080). E.H.-L. reports a fellowship from the Spanish Ministry of Science, Innovation, and Universities. |
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| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
© 2020
American Academy of Allergy, Asthma & Immunology. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 147 - N° 3
P. 1095 - Marzo 2021 Ritorno al numero
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