Polygenic risk score for atopic dermatitis in the Canadian population - 09/01/21
Doi : 10.1016/j.jaci.2020.04.057
Mathieu Simard, BSc a, b, Anne-Marie Madore, PhD a, Simon Girard, PhD a, b, Susan Waserman, MD, MSc c, Qingling Duan, PhD d, Padmaja Subbarao, MD, MSc e, Malcolm R. Sears, MBChB f, Theo J. Moraes, MD, PhD e, Allan B. Becker, MD g, Stuart E. Turvey, MBBS, DPhil h, Piushkumar J. Mandhane, MD, PhD i, Charles Morin, MD a, j, Philippe Bégin, MD, PhD k, l, Catherine Laprise, PhD a, b, j 
a Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada
b Centre intersectoriel en santé durable, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada
c Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
d School of Computing and Department of Biomedical & Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
e Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
f Division of Respirology, McMaster University, Hamilton, Ontario, Canada
g Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
h Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
i Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
j Department of Pediatrics, Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-Saint-Jean, Saguenay, Quebec, Canada
k Department of Medicine, Centre hospitalier de l’Université de Montréal, Montreal, Quebec, Canada
l Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada
| M.S. is supported by a Fonds de recherche du Québec - Santé (FRQS) Master’s Training Award. This study had support from the Quebec Respiratory Health Network (RHN; en/) pilot project grants and by the Canada Research Chair in the Environment and Genetics of Respiratory Disorders and Allergy. The Canadian Institutes of Health Research (CIHR), and the Allergy, Genes and Environment (AllerGen) Network of Centres of Excellence provided core support for the CHILD study. C.L. is part of the Quebec RHN, the investigator of the CHILD study, the director of the Centre intersectoriel en santé durable de l’UQAC and the chairholder of the Canada Research Chair in the Environment and Genetics of Respiratory Disorders and Allergy (www.chairs.gc.ca). The GWAS data were made available by the European Commission as part of GABRIEL (A multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community) contract number 018996 under the Integrated Program LSH-2004-1.2.5-1 (Post genomic approaches to understand the molecular basis of asthma aiming at a preventive or therapeutic control). This study makes use of data generated by the UK10K Consortium. A full list of the investigators who contributed to the generation of the data is available from www.UK10K.org. Funding for UK10K was provided by the Wellcome Trust under award WT091310. |
|
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
© 2020
The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 147 - N° 1
P. 406-409 - Gennaio 2021 Ritorno al numero
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