Acromegaly is associated with vertebral deformations but not vertebral fractures: Results of a cross-sectional monocentric study - 28/11/20
, Clarisse Hochman b, 1, Samy Hadjadj a, Benoît Le Goff b, Yves Maugars b, Bertrand Cariou a, Delphine Drui a, 2, Pascale Guillot b, 2Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Highlights |
• | Acromegalic patients had low prevalence of vertebral fractures. |
• | Study of qualitative abnormalities of the spine in acromegalic patients. |
• | Acromegalic patient had high prevalence of spinal frank deformations. |
Abstract |
Objectives |
Patients with acromegaly appear to be at increased risk of vertebral fractures despite normal bone mineral density. We investigated the prevalence of vertebral fractures in a cohort of acromegalic patients under 80 years of age.
Methods |
Monocentric cross-sectional study performed at Nantes University Hospital from 1988 to 2018. Fifty patients (18 females, 32 males) with a median age of 52.3 years (range: 27–78) were included. Radiological vertebral fractures were evaluated on conventional lumbar and thoracic spine radiographs using Genant's semiquantitative fracture assessment. We studied qualitative abnormalities of the spine using three criteria: osteophytes, disc-space narrowing and wedge-shaped vertebrae. We analysed bone mineral density and endocrine status.
Results |
Three patients (6%) had a vertebral fracture: one grade 1 and two grade 2 according to Genant's assessment, with two osteoporotic and one osteopenic patients. They had no unsubstituted pituitary deficiency. Considering the frank deformations (osteophyte or disc narrowing≥grade 2 or wedge-shaped), the thoracic spine was deformed in 22 patients (44%) and the lumbar spine in 21 patients (42%).
Conclusion |
Acromegalic patients had a low prevalence of vertebral fractures but had a significant amount of vertebral deformations. We speculate that this high prevalence of frank deformations could explain the previously reported high prevalence of vertebral fractures.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Acromegaly, Bone, Spine, Spinal fractures, Growth Hormone, Bone density.
Mappa
Vol 87 - N° 6
P. 618-624 - Dicembre 2020 Ritorno al numero
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