Metabolomics in the development and progression of rheumatoid arthritis: A systematic review - 26/09/20
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 6 |
| Iconografia | 1 |
| Video | 0 |
| Altro | 0 |
Highlights |
• | We systematically evaluated and synthesised data from various RA metabolomics studies. |
• | Trying to identify metabolites in the human body that can be diagnosed as RA. |
• | Describe the mechanisms by which important metabolites participate in rheumatoid arthritis. |
Abstract |
Objective |
A systematic review and analysis of data from several rheumatoid arthritis metabolomics studies attempts to determine which metabolites can be used as potential biomarkers for the diagnosis of rheumatoid arthritis and to explore the pathogenesis of rheumatoid arthritis.
Methods |
We searched all the subject-related documents published by EMBASE, PubMed, Web of Science, and Cochrane Library from the database to the September 2019 publication. Two researchers independently screened the literature and extracted the data. QUADOMICS tool was used to assess the quality of studies included in this systematic review.
Results |
A total of 10 studies met the inclusion criteria of systematic review, including 502 patients with rheumatoid arthritis and 373 healthy people. Among them, the biological samples utilised for metabolomic analysis include: serum (n=8), urine (n=1) and synovial fluid (n=1). Some metabolites play an important role in rheumatoid arthritis: glucose, lactic acid, citric acid, leucine, methionine, isoleucine, valine, phenylalanine, threonine, serine, proline, glutamate, histidine, alanine, cholesterol, glycerol, and ribose.
Conclusions |
Metabolomics provides important new opportunities for further research in rheumatoid arthritis and is expected to elucidate the pathogenesis of rheumatoid arthritis that has not been fully understood before.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Rheumatoid arthritis, Metabolomics, Biomarker, Systematic review
Mappa
Vol 87 - N° 5
P. 425-430 - Ottobre 2020 Ritorno al numero
Articolo precedente
- Bronchiectasis in rheumatoid arthritis. A clinical appraisial
- Ana Catarina Duarte, Joanna Porter, Maria José Leandro
- Managing patients with rheumatic diseases during the COVID-19 pandemic: The French Society of Rheumatology answers to most frequently asked questions up to May 2020
- Christophe Richez, René-Marc Flipo, Francis Berenbaum, Alain Cantagrel, Pascal Claudepierre, Françoise Debiais, Philippe Dieudé, Philippe Goupille, Christian Roux, Thierry Schaeverbeke, Daniel Wendling, Thao Pham, Thierry Thomas
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?