Gammadelta T cells as a predictor of surgical relapse of Crohn's disease - 03/09/20
, I. Catalán-Serra b, e, f , R. Gil-Borrás b , P. Marqués-García b , C. García-Ballesteros c , F. López Chuliá c , C. Cuéllar d Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Highlights |
• | What is already known on this subject? |
• | Deficit of γδ T cell is related with Crohn's Disease. |
• | What are the new findings? |
• | There is a relationship between deficit of γδ T cell and risk of surgical relapse in CD. |
• | How might it impact on clinical practice in the foreseeable future? |
• | γδ T cells could be used as markers of a surgical complication of CD. |
Summary |
Background |
We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD patients. The aim of this study is to study the correlation between αβ and γδ T cell subsets in the peripheral blood of patients with CD and the risk for surgery during follow up.
Methods |
A prospective study of 102 patients with CD compared with 102 healthy subjects (control group) matched by age and sex was conducted. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, and αβ and γδ T cell subsets were measured in the peripheral blood of all participants.
Results |
We found evidence of a relationship between lower γδ T cell levels and risk of surgical relapse in CD. The lowest subsets observed in CD patients with surgical relapse were CD3+γδ, CD3+CD8+γδ and CD3+CD56+γδT cells. We observed a relationship between a decrease in γδ T cells and the most severe forms of the disease. The lowest levels of CD3+γδ and CD3+CD8+γδT cells were observed in the fistulizing phenotype.
Conclusions |
The deficit of γδ T cells was related with the severity and the risk for surgical relapse in CD patients. Patients with CD3+γδ deficit were more prone to surgery than patients without this deficit. These results suggest that γδ T cells could be used as markers of poor prognosis of CD following the diagnosis of the disease.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Crohn's Disease, Gammadelta T cells, Surgery, Relapse
Abbreviations : CD, TCR, CDAI
Mappa
Vol 44 - N° 4
P. 586-597 - Settembre 2020 Ritorno al numero
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