Characterization of biopsy proven non-alcoholic fatty liver disease in healthy non-obese and lean population of living liver donors: The impact of uric acid - 03/09/20
, Saman Nikeghbalian, Bita Geramizadeh, Kourosh Kazemi, Alireza Shamsaeefar, Seyed Ali Malek-HosseiniBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 7 |
| Iconografia | 1 |
| Video | 0 |
| Altro | 0 |
Highlights |
• | Biopsy proven NAFLD in metabolically healthy non-obese and lean individuals has not been well characterized. |
• | NAFLD diagnosed by liver biopsy is prevalent in healthy lean individuals. |
• | Higher body mass index and uric acid are risk factors of NAFLD in lean individuals. |
Summary |
Background |
Non-alcoholic fatty liver disease (NAFLD) is frequently seen among non-obese overweight individuals and lean subjects (those with normal body mass index). This study aimed to investigate prevalence and risk factors of biopsy proven NAFLD in a cluster of healthy non-obese and lean individuals.
Methods and Materials |
In a retrospective study, adult (>18 years) apparently healthy individuals who had donated liver to pediatric patients between July 2012 and October 2018 were included. Non-obese and lean individuals were defined as BMI<30kg/m2 and BMI<25kg/m2, respectively.
Results |
Totally 310 patients were included. Seventy-six individuals (24.5%) had NAFL and 30 patients (9.67%) had non-alcoholic steatohepatitis (NASH) among non-obese population. In multivariate regression analysis, only higher BMI was marginally associated with NASH in non-obese compared to those without NASH (Odds ratio: 2.52, 95% CI: 0.097–6.54; P=0.05). Totally, 246 individuals were lean. 55 individuals (22.3%) had NAFL and 20 individuals (8.2%) had NASH in their liver biopsies. In univariate analysis, serum triglyceride, cholesterol, LDL, ALT, alkaline phosphatase and uric acid were associated with NAFL among lean individuals (P<0.05). In regression analysis, serum uric acid was associated with NAFL (Odds ratio: 1.70, 95% CI: 1.18–2.45; P=0.004) and NASH in lean individuals (Odds ratio: 1.98, 95% CI: 1.27–3.10; P=0.003).
Conclusion |
NAFLD/NASH is prevalent even in a healthy lean population when evaluated by liver biopsy. Higher BMI and serum uric acid were two major risks of NAFLD/NASH in non-obese and lean individuals.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Non-alcoholic fatty liver disease, Lean individuals, Non-alcoholic steatohepatitis, Liver biopsy
Abbreviations : NAFLD, NASH, BMI, AST, ALT
Mappa
Vol 44 - N° 4
P. 572-578 - Settembre 2020 Ritorno al numero
Articolo precedente
- Anastomotic bilio-biliary stricture after adult liver transplantation: A retrospective study over 20 years in a single center
- Jérôme Dumortier, Christine Chambon-Augoyard, Olivier Guillaud, Mathieu Pioche, Jérôme Rivory, Pierre-Jean Valette, Mustapha Adham, Thierry Ponchon, Jean-Yves Scoazec, Olivier Boillot
- Drastic decrease of urgent endoscopies outside regular working hours during the Covid-19 pandemic in the paris area
- Aymeric Becq, Benedicte Jais, Clémence Fron, Hugo Rotkopf, Guillaume Perrod, Marika Rudler, Dominique Thabut, Abdellah Hedjoudje, Maxime Palazzo, Aurélien Amiot, Iradj Sobhani, Xavier Dray, Marine Camus, On behalf of the Parisian On-call Endoscopy Team (POET), Aurélien Amiot, Maximilien Barret, Aymeric Becq, Marine Camus, Nicolas Carbonell, Xavier Dray, Elia Gigante, Déborah Hassid, Julien Kirchgesner, Cécilia Landman, Romain Leenhardt, Marie Lequoy, Nelson Lourenco, Chloé Martineau, Jean-Charles Nault, Violaine Ozenne, Anna Pellat, Olivia Pietri, Mathilde Roche, Heithem Soliman, Nils Steuer, My-Linh Tran-Minh, Guillaume Velut, Aziz Zaanan
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?