Mechanisms of skin autoimmunity: Cellular and soluble immune components of the skin - 22/07/20
Abstract |
Autoimmune diseases are driven by either T cells or antibodies reacting specifically to 1 or more self-antigens. Although a number of self-antigens associated with skin diseases have been identified, the causative antigen(s) remains unknown in the great majority of skin diseases suspected to be autoimmune driven. Model diseases such as pemphigus, dermatitis herpetiformis, and more recently psoriasis have added greatly to our understanding of skin autoimmunity. Depending on the dominant T- or B-cell phenotype, skin autoimmune diseases usually follow 1 of 6 immune response patterns: lichenoid, eczematous, bullous, psoriatic, fibrogenic, or granulomatous. Usually, skin autoimmunity develops as a consequence of several events—an altered microbiome, inherited dysfunctional immunity, antigens activating innate immunity, epigenetic modifications, sex predisposition, and impact of antigens either as neoantigen or through molecular mimicry. This review summarizes currently known antigens of skin autoimmune diseases and discusses mechanisms of skin autoimmunity.
Il testo completo di questo articolo è disponibile in PDF.Key words : Immune response pattern, autoimmunity, T cell, B cell, autoantigen
Abbreviations used : AA, BP, CD, Dsg, ncISD, Trm
Mappa
K.E. is supported by a European Research Council (ERC) grant (Individualized Medicine in inflammatory Skin diseases [IMCIS], 676858) and the German Research Foundation (grant no. EY97/3-2). |
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Terms in boldface and italics are detailed in the glossary on page 9. |
Vol 146 - N° 1
P. 8-16 - Luglio 2020 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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