The immunologic status of newborns born to SARS-CoV-2–infected mothers in Wuhan, China - 22/07/20
, Jiafu Li, MD b, Yuanzhen Zhang, MD b
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.
Si connetta per beneficiarne
Abstract |
Background |
Immunologic dysfunction due to coronavirus disease 2019 (COVID-19) is closely related to clinical prognosis, and the inflammatory response of pregnant women may affect the directional differentiation and function of fetal immune cells.
Objective |
We sought to analyze the immune status of newborns from mothers with COVID-19 in the third trimester.
Methods |
Along with collecting the clinical data from 51 newborns and their respective mothers, we recorded the immunophenotypes and cytokine and immunoglobulin levels of the newborns.
Results |
None of the 51 newborns showed fever or respiratory distress during hospitalization. Detection of severe acute respiratory syndrome coronavirus 2 nucleic acid in pharyngeal swabs was negative. Except for the low level of CD16-CD56 cells, the count and proportion of lymphocytes, CD3, CD4, CD8, and CD19 were all in the normal range. Moreover, the serum IgG and IgM levels were within the normal range, whereas IL-6 showed increased levels. There was no correlation between maternal COVID-19 duration and the lymphocyte subsets or cytokine levels (IFN-γ, IL-2, IL-4, IL-6, IL-10, and TNF-α). There was a positive correlation between IL-6 and IL-10 levels and CD16-CD56 cells. One (1.96%) infant with an extremely elevated IL-6 concentration developed necrotizing enterocolitis in the third week after birth, and the remaining 50 infants did not show abnormal symptoms through the end of the follow-up period.
Conclusions |
COVID-19 in the third trimester did not significantly affect the cellular and humoral immunity of the fetus, and there was no evidence that the differentiation of lymphocyte subsets was seriously unbalanced.
Il testo completo di questo articolo è disponibile in PDF.Key words : Newborn, pregnant women, COVID-19, third-trimester, lymphocyte subsets and cytokines
Abbreviations used : ALC, BW, COVID-19, GA, NEC, SARS-CoV-2
Mappa
| This work was supported by the Science and Technology Department of Hubei Province (grant no. 2019-nCoV. No. 2020FCA011). |
|
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 146 - N° 1
P. 101 - Luglio 2020 Ritorno al numero
Articolo precedente
- Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China
- Ruchong Chen, Ling Sang, Mei Jiang, Zhaowei Yang, Nan Jia, Wanyi Fu, Jiaxing Xie, Weijie Guan, Wenhua Liang, Zhengyi Ni, Yu Hu, Lei Liu, Hong Shan, Chunliang Lei, Yixiang Peng, Li Wei, Yong Liu, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Zhong Chen, Gang Li, Zhijian Zheng, Shaoqin Qiu, Jie Luo, Changjiang Ye, Shaoyong Zhu, Jinping Zheng, Nuofu Zhang, Yimin Li, Jianxing He, Jing Li, Shiyue Li, Nanshan Zhong, Medical Treatment Expert Group for COVID-19
- Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
- Xiaochen Li, Shuyun Xu, Muqing Yu, Ke Wang, Yu Tao, Ying Zhou, Jing Shi, Min Zhou, Bo Wu, Zhenyu Yang, Cong Zhang, Junqing Yue, Zhiguo Zhang, Harald Renz, Xiansheng Liu, Jungang Xie, Min Xie, Jianping Zhao
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.