Toward personalization of asthma treatment according to trigger factors - 08/06/20
Doi : 10.1016/j.jaci.2020.02.001
Katarzyna Niespodziana, PhD a, Kristina Borochova, MSc a, Petra Pazderova, MSc a, Thomas Schlederer, PhD a, Natalia Astafyeva, MD, PhD b, Tatiana Baranovskaya, MD c, Mohamed-Ridha Barbouche, MD, PhD d, Evgeny Beltyukov, MD, DSc e, Angelika Berger, MD f, Elena Borzova, MD, PhD g, h, i, Jean Bousquet, MD j, k, l, Roxana S. Bumbacea, MD, PhD m, Snezhana Bychkovskaya, MD n, Luis Caraballo, MD o, Kian Fan Chung, MD, DSc, FRCP p, q, Adnan Custovic, MD, PhD, FRCP, FAAAI p, q, Guillermo Docena, PhD r, Thomas Eiwegger, MD s, t, u, Irina Evsegneeva, MD v, Alexander Emelyanov, MD, PhD w, Peter Errhalt, MD x, Rustem Fassakhov, MD, PhD y, Rezeda Fayzullina, MD, DSc z, Elena Fedenko, MD, PhD aa, Daria Fomina, MD, PhD v, bb, Zhongshan Gao, PhD cc, Pedro Giavina-Bianchi, MD, PhD dd, Maia Gotua, MD, PhD ee, Susanne Greber-Platzer, MD, MBA ff, Gunilla Hedlin, MD, PhD gg, hh, Natalia Ilina, MD aa, Zhanat Ispayeva, MD, PhD ii, Marco Idzko, MD jj, Sebastian L. Johnston, MD, PhD p, q, Ömer Kalayci, MD kk, Alexander Karaulov, MD, PhD v, Antonina Karsonova, MD, PhD v, Musa Khaitov, MD, DSc aa, Elena Kovzel, MD, PhD ll, Marek L. Kowalski, MD, PhD mm, Dmitry Kudlay, MD, PhD aa, Michael Levin, MD, PhD nn, Svetlana Makarova, PhD oo, Paolo Maria Matricardi, MD pp, Kari C. Nadeau, MD, PhD qq, Leyla Namazova-Baranova, MD rr, Olga Naumova, MD, PhD ss, Oleksandr Nazarenko, MD, PhD tt, Paul M. O’Byrne, MB, BCh, FRCP(C) uu, Faith Osier, MBChB, PhD vv, Alexander N. Pampura, MD, PhD ww, Carmen Panaitescu, MD, PhD xx, Nikolaos G. Papadopoulos, MD, PhD yy, zz, Hae-Sim Park, MD aaa, Ruby Pawankar, MD, PhD, FRCP, FAAAAI bbb, Wolfgang Pohl, MD ccc, Harald Renz, MD ddd, Ksenja Riabova, MD v, Vanitha Sampath, PhD qq, Bülent E. Sekerel, MD kk, Elopy Sibanda, MD, PhD eee, fff, Valérie Siroux, PhD ggg, Ludmila P. Sizyakina, MD, PhD hhh, Jin-Lyu Sun, MD, PhD iii, Zsolt Szepfalusi, MD ff, Tetiana Umanets, PhD jjj, Hugo P.S. Van Bever, MD, PhD kkk, Marianne van Hage, MD lll, Margarita Vasileva, CMS mmm, Erika von Mutius, MD, MSc nnn, ooo, ppp, Jiu-Yao Wang, MD, PhD qqq, Gary W.K. Wong, MD rrr, Sergii Zaikov, MD sss, Mihaela Zidarn, MD, PhD ttt, uuu, Rudolf Valenta, MD, PhD a, v, aa, vvv, www, ⁎ 
a Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
b Department of Clinical Immunology and Allergology of Saratov State Medical University, Saratov, Russia
c Belarusian Medical Academy of Post Diploma Studies, Minsk, Belarus
d Department of Immunology, Institut Pasteur de Tunis, Tunis, Tunisia
e Department of Faculty Therapy, Endocrinology, Allergology and Immunology, Ural State Medical University, Ekaterinburg, Russia
f Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria
g Department of Clinical Allergology and Immunology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia
h Department of Clinical Genetics, Research and Clinical Institute for Pediatrics named after Yuri Veltischev at the Pirogov Russian National Research Medical University, Moscow, Russia
i Department of Dermatology and Venereology, I.V. Sechenov First State Medical University, Moscow, Russia
j University Hospital, Montpellier, France
k MACVIA-France, Montpellier, France
l Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany
m Department of Allergology and Clinical Immunology, University of Medicine and Pharmacy “Carol Davila,” Bucharest, Romania
n Department of Pediatrics, Krasnoyarsk Medical University, Kransnoyarsk, Russia
o Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia
p National Heart & Lung Institute, Imperial College London, London, United Kingdom
q MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
r Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
s Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
t Department of Immunology, University of Toronto, Toronto, Ontario, Canada
u Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, Hospital for Sick Children, Departments of Paedriatrics and Immunology, University of Toronto, Toronto, Ontario, Canada
v Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia
w Department of Respiratory Medicine and Allergy, North-Western Medical University, St Petersburg, Russia
x Department of Pneumology, University Hospital Krems and Karl Landsteiner University of Health Sciences, Krems, Austria
y Institute of Fundamental Medicine and Biology of Kazan Federal University, Kazan, Russia
z Faculty of Pediatrics, Bashkir State Medical University, Ufa, Russia
aa NRC Institute of Immunology FMBA of Russia, Moscow, Russia
bb City Moscow Center of Allergy and Immunology, Clinical Hospital No. 52, Moscow, Russia
cc Allergy Research Center, Zhejiang University, Hangzhou, China
dd Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil
ee Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia
ff Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center Pediatrics, Medical University of Vienna, Vienna, Austria
gg Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
hh Department of Womenś and Children’s Health, Karolinska Institutet, Stockholm, Sweden
ii Allergology Department, Kazakh National Medical University, Almaty, Kazakhstan
jj Department of Pneumology, Medical University of Vienna, Vienna, Austria
kk Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey
ll Department of Clinical Immunology, Allergology, Pulmonology, Republic Diagnostic Center, Corporate Fund University Medical Center of Nazarbayev University, Nur-Sultan, Kazakhstan
mm Department of Allergy and Immunology, Medical University Lodz, Lodz, Poland
nn Division of Asthma and Allergy, University of Cape Town, Cape Town, South Africa
oo Department of Preventive Pediatrics, National Medical Research Center for Children’s Health, Moscow, Russia
pp Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité-University Medicine Berlin, Berlin, Germany
qq Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif
rr Department of Pediatrics, Russian National Research Medical University of MoH RF, Moscow, Russia
ss Center of Allergic Diseases of Upper Respiratory Ways, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
tt Department of Clinical and Laboratory Allergology and Immunology, National Medical Academy of Postgraduate Education, Kyiv, Ukraine
uu Firestone Institute of Respiratory Health, Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada
vv KEMRI-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya
ww Department of Allergology and Clinical Immunology, Research and Clinical Institute for Pediatrics named after Yuri Veltischev at the Pirogov Russian National Research Medical University of the Russian Ministry of Health, Moscow, Russia
xx OncoGen Center, County Clinical Emergency Hospital “Pius Branzeu,” and University of Medicine and Pharmacy V Babes, Timisoara, Romania
yy Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom
zz Allergy Department, 2nd Pediatric Clinic, National Kapodistrian University of Athens, Athens, Greece
aaa Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
bbb Department of Pediatrics, Nippon Medical School, Tokyo, Japan
ccc Pulmonary Department and Karl Landsteiner Institute for Clinical and Experimental Pulmology, Hietzing Hospital, Vienna, Austria
ddd Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL) Marburg, Marburg, Germany
eee Asthma, Allergy and Immune Dysfunction Clinic, Twin Palms Medical Centre, Harare, Zimbabwe
fff Department of Pathology, Medical School, National University of Science and Technology, Bulawayo, Zimbabwe
ggg Univ. Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, Grenoble, France
hhh Department of Allergology and Immunology, Rostov Medical University, Rostov, Russia
iii Department of Allergy and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
jjj Department of Respiratory Diseases and Respiratory Allergy in Children, Institute of Pediatrics, Obstetrics and Gynecology, National Academy of Medical Sciences, Kyiv, Ukraine
kkk Department of Paediatrics, National University of Singapore, Singapore, Singapore
lll Division of Immunology and Allergy, Department of Medicine, Karolinska Institutet and University Hospital, Stockholm
mmm Center of Allergology and Clinical Immunology, Regional Clinical Hospital, Khabarovsk, Russia
nnn Dr. von Hauner Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany
ooo Institute of Asthma and Allergy Prevention, Helmholtz Centre Munich, Munich, Germany
ppp German Centre for Lung Research, Germany
qqq Center for Allergy and Clinical Immunology Research (ACIR), Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
rrr Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
sss Department of Phtihisiatry and Pulmonology, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
ttt University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia
uuu Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
vvv Division of Immunology and Allergy, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
www Karl Landsteiner University, Krems, Austria
∗Corresponding author: Rudolf Valenta, MD, PhD, Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 3Q, 1090 Vienna, Austria.Division of ImmunopathologyDepartment of Pathophysiology and Allergy ResearchCenter for PathophysiologyInfectiology and ImmunologyMedical University of ViennaWaehringer Guertel 18-203QVienna1090Austria
Abstract |
Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.
Il testo completo di questo articolo è disponibile in PDF.Key words : Asthma, allergy, wheeze, rhinovirus, allergen, microarray
Abbreviations used : GINA, RV
Mappa
| Disclosure of potential conflict of interest K. Niespodziana receives grant support (grant no. P29398) from the Austrian Science Foundation (FWF). K. F. Chung has received honoraria for participating in advisory board meetings of GlaxoSmithKline (GSK), AstraZeneca, Novartis, Merck, Boehringer Ingelheim, and Teva regarding treatments for asthma and chronic obstructive pulmonary disease and has also been renumerated for speaking engagements. A. Custovic reports personal fees from Novartis, Regeneron, Thermo Fisher Scientific, Philips, and Sanofi, outside the submitted work. T. Eiwegger reports other fees from DBV, grants from Innovation fund Denmark, and other fees from Regeneron, outside the submitted work; is the Co-PI or scientific lead in 3 investigator-initiated oral immunotherapy trials supported by the Allergy and Anaphylaxis Program Sickkids; is on local advisory board for ALK; and serves as associate editor for Allergy. S. L. Johnston reports board memberships of Therapeutic Frontiers and Virtus Respiratory Research and personal fees from Myelo Therapeutics GmbH, Concert Pharmaceuticals, Bayer, Synairgen, Novartis, Boehringer Ingelheim, Chiesi, Gerson Lehrman Group, resTORbio, Bioforce, Materia Medical Holdings, PrepBio Pharma, Pulmotect, Virion Health, and Lallemand Pharma, outside the submitted work. K. C. Nadeau reports grants and other fees from the National Institute of Allergy and Infectious Diseases; other fees from Novartis; personal fees and other fees from Regeneron; grants and other fees from FARE; grants from EAT; other fees from Sanofi, Astellas, Nestle, BeforeBrands, Alladapt, ForTra, Genentech, AImmune Therapeutics, and DBV Technologies; personal fees from AstraZeneca, ImmuneWorks, and Cour; grants from Allergenis and Ukko; and other fees from AnaptysBio, Adare Pharmaceuticals, Stallergenes-Greer, the National Heart, Lung, and Blood Institute, NIEHS, EPA, and WAO Center of Excellence, outside the submitted work. P. M. O’Byrne reports grants and personal fees from AstrZeneca and Medimmune; grants from Novartis; and personal fees from GSK and Chiesi, outside the submitted work. N. G. Papadopoulos reports personal fees from Novartis, Nutricia, HAL, Menarini/FAES Farma, Sanofi, Mylan/Meda, Biomay, AstraZeneca, GSK, MSD, ASIT Biotech, and Boehringer Ingelheim and grants from Gerolymatos International SA and Capricare, outside the submitted work. W. Pohl reports personal fees from Astra Zeneca, Chiesi, GSK, Meda, Sanofi, Novartis, Teva, and Boehringer Ingelheim, outside the submitted work. V. Siroux reports grants from Aviesan Itmo santée publique, the Scientific committee “AGIR for chronic diseases,” and the French National Research Agency (ANR), during the conduct of the study. M. van Hage reports personal fees from Thermo Fisher Scientific, ALK, and Biomay AG, Vienna, Austria, outside the submitted work. E. von Mutius reports personal fees from OM Pharma S. A., Böhringer Ingelheim International GmbH, Peptinnovate Ltd, Pharmaventures Ltd, and Nestlé Deutschland AG, outside the submitted work. In addition, E. von Mutius has a patent application number LU101064, Barn dust extract for the prevention and treatment of diseases, pending; a patent publication number EP2361632: Specific environmental bacteria for the protection from and/or the treatment of allergic, chronic inflammatory and/or autoimmune disorders; with royalties paid to Protectimmun GmbH, a patent publication number EP 1411977: Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases; licensed to Protectimmun GmbH, a patent publication number EP1637147: Stable dust extract for allergy protection; and a patent publication number EP 1964570: Pharmaceutical compound to protect against allergies and inflammatory diseases licensed to Protectimmun GmbH. M. Zidarn reports personal fees from Takeda and Novartis, outside the submitted work. R. Valenta receives grant support from the Austrian Science Foundation (FWF) and Viravaxx, Vienna, Austria. Furthermore, R. Valenta is a recipient of a megagrant of the Government of the Russian Federation (grant no. 14.W03.31.0024) and serves as a consultant for Viravaxx, Vienna, Austria. In addition, S. L. Johnston, K. Niespodziana, and R. Valenta are authors of patent/patent applications related to the subject of the study. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2020
The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 145 - N° 6
P. 1529-1534 - Giugno 2020 Ritorno al numero
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