Chronic osteitis and squamous-cell carcinoma is a rare but classically described association. We report three cases of chronic tibial osteitis which developed into an open leg wound. During the monitoring, after a latency period of several years, local signs developed: biopsy provided the diagnosis of degenerative carcinomatosis. The search for locoregional extension or metastatic dissemination was negative. All three patients underwent amputation with good results.

This small series, together with a review of the literature, enabled us to describe the principle epidemiological and diagnostic features, focusing on early signs. The appropriate management scheme remains to be determined, although amputation, which some may consider a failure, should not be postponed indefinitely.