Long non-coding RNA LINC00472 suppresses hepatocellular carcinoma cell proliferation, migration and invasion through miR-93-5p/PDCD4 pathway - 25/07/19
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Highlights |
• | LINC00472 is down-expressed in hepatocellular carcinoma cell and decreased LINC00472 expression predicts poor prognosis in HCC patients. |
• | Forced expression of LINC00472 inhibits hepatocellular carcinoma cell proliferation, migration and invasion. |
• | MiR-93-5p was a direct target of LINC00472, and miR-93-5p directly targeted PDCD4. |
• | The miR-93-5p/PDCD4 pathway mediated the suppressing role of LINC00472 in HCC cell. |
Summary |
Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths. In the present study, we have demonstrated that long non-coding RNA (lncRNA) LINC00472 was low expressed in human HCC tissues and cell lines compared with adjacent non-tumor liver tissues and normal liver cell lines respectively. LINC00472 was also low expressed in HCC tissues from patients with metastasis compared with tissues from patients without metastasis. Expression level of LINC00472 was positively correlated with patient overall survival (OS) rate. Forced expression of LINC00472 suppressed cell proliferation, migration, invasion and promoted cell apoptosis in HCC cells Huh-7 and SMMC-7721. MiR-93-5p was a direct target of LINC00472, and miR-93-5p directly targeted PDCD4. The miR-93-5p/PDCD4 pathway mediated the suppressing role of LINC00472 in HCC cells. Therefore, LINC00472 was an important tumor suppressor in human HCC, which could be used as a bio-marker for HCC therapy.
Il testo completo di questo articolo è disponibile in PDF.Keywords : LINC00472, Proliferation, Migration, Invasion, Hepatocellular carcinoma
Mappa
Vol 43 - N° 4
P. 436-445 - Agosto 2019 Ritorno al numero
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