Early high levels of regulatory T cells and T helper 1 may predict the progression of recurrent hepatitis C after liver transplantation - 18/06/19
, O. Morales c, C. Barjon a, e, G. Dahlqvist a, d, L. Aoudjehane a, f, L. Ouaguia c, N. Delhem c, 2, F. Conti a, g, 2Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Highlights |
• | Tregs may suppress early antiviral response after LT in HCV+ patients. |
• | Evaluating Tregs early after LT can help for better patient follow-up. |
• | Tregs may be predictive of severe recurrence. |
Summary |
Background |
Immune response failure against hepatitis C virus (HCV) has been associated with an increased regulatory T cell (Treg) activity. After liver transplantation (LT), 80% of patients experience an accelerated progression of hepatitis C recurrence. The aim of this work was to assess the involvement of Tregs, T helper (Th) 1, 2 and 17 cells in recurrent hepatitis C.
Methods |
Peripheral blood cells obtained before and one month after LT from 22 recipients were analysed. Forty-four key molecules related to Treg, Th1, 2 and 17 responses, were evaluated using qRT-PCR. Liver recipients were classified in two groups according to graft fibrosis evaluated by the METAVIR score on the biopsy performed one year after LT (mild: F ≤ 1, n = 13; severe: F > 1, n = 9). Patients developing a severe recurrence were compared with patients with a mild recurrence.
Results |
mRNA levels of Treg markers obtained one month after LT were significantly increased in patients with a severe disease course when compared to patients with a mild recurrence. Markers of the Th1 response were elevated in the same group. No differences in the markers determined before LT were observed.
Conclusion |
These findings suggest that Treg, induced by a multifactorial process, which could include a strong Th1 response itself, may play a role in suppressing the early antiviral response, leading to a severe recurrence of hepatitis C.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Liver transplantation, Hepatitis C, Regulatory T cells, Tr1, Th1, HCV recurrence
Abbreviations : ATG, CCR7, CD, CD40L, CTLA-4, CXCR4, G3PDG, GATA3, GITR, HCV, ICAM-1, IL, IL-10Ra/B, IFN, LAG-3, LT, MMF, nTreg, PBMC, PD-1, PDGF, PDL-1/2, Tac, TBX21/Tbet, TGF, Th1, Th2, Th17, Tr1, VEGF, 28S
Mappa
Vol 43 - N° 3
P. 273-281 - Giugno 2019 Ritorno al numero
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