Blood lead level in patients with irritable bowel syndrome - 25/04/19
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Summary |
Background |
Irritable bowel syndrome and elevated blood lead level share certain gastrointestinal symptoms.
Objective |
We measured blood lead levels in IBS patients, comparing them with IBS severity.
Methods |
This cross-sectional study included 324 patients with newly diagnosed IBS and 147 healthy subjects as control. All participants completed a questionnaire on their current gastrointestinal symptoms and a blood sample was taken so as to determine the blood lead level via atomic absorption spectrophotometer technique. Patients were subsequently assessed in terms of IBS severity.
Findings |
Mean blood lead level was significantly higher in the IBS group compared to the control group (7.5±5.4mcg/dL vs. 5.8±3.4mcg/dL, P=0.001). Moreover, 59% of IBS patients and 44% of the healthy subjects had blood lead level>5mcg/dL (P=0.004). Only 38% of patients with diarrhea alone versus 59–83% in the other groups had high blood lead levels (P<0.001). Mean IBS-SSS was 241±92.6 in IBS patients, who with elevated blood lead level had significantly higher grades compared to those with blood lead levels<5mcg/dL. Linear regression analysis indicated a positive correlation between blood lead level and severity of gastrointestinal manifestations measured by IBS-SSS (ß=7.2; 95% CI: 5.5–8.9; P<0.001).
Conclusion |
High blood lead level may be a concern in IBS patients, particularly in IBS-C and unclassified IBS groups and those with severe gastrointestinal manifestations.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Blood lead, Irritable bowel syndrome
Mappa
Vol 31 - N° 2
P. 95-99 - Maggio 2019 Ritorno al numero
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