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A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes - 10/01/19

Doi : 10.1016/j.accpm.2018.05.012 
Serge Molliex a, , Sylvie Passot a , Jerome Morel a , Emmanuel Futier b , Jean Yves Lefrant c , Jean Michel Constantin b , Yannick Le Manach d , Bruno Pereira e

Opti-Aged group, Azurea clinical research Network1

  Contributors of the Opti-aged group are listed in the Appendix A.
N. Bruder f, C. Vaisse f, C. Bechis g, L. Bernard g, M. Leone g, M. Poirier g, A. Vincent g, N. Abdelkrim h, C. Paugam h, F. Lion i, P. Montravers i, O. Langeron j, M. Raux j, M. Baussier k, K. Xu k, F. Bart l, S. Dagois l, B. Plaud l, C. Rabuel l, E. Roland l, M. Biais m, K. Nouette-Gaulain m, A. Cabart n, J.L. Hanouz n, C. Lambert o, T. Godet o, S. Thibault o, B. Bouhemad p, E. Chambade p, P. Bouzat q, M. Garot r, G. Lebuffe r, F. Lallemant s, C. Lemery s, B. Tavernier s, A. de Jong t, S. Jaber t, D. Verzilli t, M. Delannoy u, C. Meistelman u, M. Carles v, L. Tran v, S. Bertran w, P. Cuvillon w, J. Ripart w, S. Simon-Pene w, M. Boisson x, B. Debaene x, H. Beloeil y, G. Godet y, O. Collange z, P.M. Mertes z, P. Diemunsch aa, D. Joganah aa, L. Oehlkern aa, M. Baulieu ab, B. Beauchesne ab, A.M. Beraud ab, S. Berthier-Berrada ab, J.Y. Bien ab, G. Dupont ab, J. Gavory ab, P. Lambert ab, J. Lanoiselée ab, P. Zufferey ab, F. Ferré ac, C. Martin ac, V. Minville ac, B. Planté ac, B. Baffeleuf ad, M. Ben Abdelkarim ad, J.S. David ad, P. Incagnoli ad, M. Khaled ad, M.C. Laplace ad, M. Lefevre ad, V. Piriou ad, F. Aubrun ae, V. Cero af, C. Delsuc af, C. Faulcon af, P. Meuret af, T. Rimmelé af, C. Truc af
f Hôpital de La Timone, AP–HM, Marseille, France 
g Hôpital Nord, AP–HM, Marseille, France 
h Hôpital Beaujon, AP–HP, Paris, France 
i Hôpital Bichat, AP–HP, Paris, France 
j Hôpital Pitié-Salpêtrière, AP–HP, Paris, France 
k Hôpital Saint-Antoine, AP–HP, Paris, France 
l Hôpital Saint-Louis et Lariboisière, AP–HP, Paris, France 
m CHU de Bordeaux, Bordeaux, France 
n CHU de Caen, Caen, France 
o CHU de Clermont-Ferrand, Clermont-Ferrand, France 
p CHU de Dijon, Dijon, France 
q CHU de Grenoble, Grenoble, France 
r Hôpital Huriez, CHU de Lille, Lille, France 
s Hôpital Salengro, CHU de Lille, Lille, France 
t Hôpital Saint-Éloi, CHU de Montpellier, Montpellier, France 
u CHU de Nancy, Nancy, France 
v Hôpital Larchet 2, CHU de Nice, Nice, France 
w CHU de Nîmes, Nîmes, France 
x CHU de Poitiers, Poitiers, France 
y CHU de Rennes, Rennes, France 
z Hôpital Central, CHU de Strasbourg, Strasbourg, France 
aa Hôpital de Hautepierre, CHU de Strasbourg, Strasbourg, France 
ab CHU de Saint-Étienne, Saint-Étienne, France 
ac CHU de Toulouse, Toulouse, France 
ad Centre hospitalier Lyon Sud, hospices civils de Lyon, Lyon, France 
ae Hôpital de la Croix-Rousse, hospices civils de Lyon, Lyon, France 
af Hôpital Édouard-Herriot, hospices civils de Lyon, Lyon, France 

a Department of Anaesthesiology and Critical Care Medicine, Centre Hospitalier Universitaire (CHU) de Saint-Étienne, Université Jean-Monnet Saint-Étienne, 42055 Saint-Étienne, France 
b Department of Perioperative Medicine, Centre Hospitalier Universitaire (CHU) de Clermont-Ferrand, Université Clermont-Auvergne, CNRS, Inserm, 63000 Clermont-Ferrand, France 
c Department of Anaesthesiology, Critical Care and Emergency Medicine, Centre Hospitalier Universitaire (CHU) de Nîmes, Université de Montpellier–Nîmes, 30029 Nîmes, France 
d Departments of Anaesthesia and Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada 
e Biostatistic Unit, Direction de la Recherche Clinique (DRCI), Centre Hospitalier Universitaire (CHU) de Clermont-Ferrand, 63003 Clermont-Ferrand, France 

Corresponding author. Département d’Anesthésie et de Réanimation, CHU Hôpital Nord, 42055 Saint-Étienne cedex 2, France.Département d’Anesthésie et de Réanimation, CHU Hôpital NordSaint-Étienne cedex 242055France

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Abstract

Introduction

In elderly patients, goal-directed haemodynamic therapy (GDHT), depth of anaesthesia monitoring and lung-protective ventilation have been shown to improve postoperative outcomes. The aim of this study was to evaluate current practices concerning strategies of anaesthesia optimisation in patients aged75 years.

Patients and methods

A multicentre observational study was performed from February to May 2015 in 23 French academic centres. On 30 consecutive days in each centre, patients75 years with at least one major comorbidity undergoing elective or emergency procedures (femoral-neck fractures surgery, intraperitoneal abdominal surgery or vascular surgery) were included. Patient characteristics and data related to GHDT, management of hypotension, monitoring of temperature and depth of anaesthesia, lung ventilation, point of care haemoglobin testing were collected.

Results

In total, 807 patients were included. Only 2% of patients [95% CI: 1–3] received GHDT in full accordance with guidelines. Depth of anaesthesia monitoring was largely performed (53% [95% CI: 50–56]). The multifaceted strategy of lung-protective ventilation combining low tidal volumes (6–8mL/kg), PEEP of 5–8cm cmH2O, and repeated recruitment manoeuvres, was performed in only 4% [95% CI: 3–5] of patients. A centre effect was a major determinant of variation concerning implementation of these strategies.

Discussion

In patients’75 years, strategies of anaesthesia optimisation are not in accordance with eligible guidelines. Implementation of these techniques varies independently of factors related to the patient or the type of surgery and may be dependent on the generated constraints.

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Keywords : Aged, Anaesthesia management: Monitoring, Haemodynamic, Ventilation


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