Polymorphism in the promoter region of lncRNA GAS5 is functionally associated with the risk of gastric cancer - 18/10/18
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 5 |
| Iconografia | 1 |
| Video | 0 |
| Altro | 0 |
Highlights |
• | Patients with gastric cancer (GC) were found to have significantly lower rate of genotype del/del of rs145204276 than the controls. |
• | The allele del of rs145204276 was significantly associated with a decreased risk of GC. |
• | Patients with allele del were less likely to develop lymph node metastasis and distant metastasis. |
• | For both tumor tissues and normal tissues, genotype del/del was indicative of remarkably higher expression of GAS5 than genotype ins/ins. |
• | SNP rs145204276 plays a protective role in the development of GC possibly through the regulation of GAS5. |
Summary |
Background and aims |
Previous studies showed that down-regulation of GAS5 was involved in the development of gastric cancer (GC). However, the regulatory mechanism of down-expressed GAS5 in GC remains obscure. We aimed to investigate the role of rs145204276 of GAS5 in the development and metastasis process of GC.
Methods |
853 GC patients and 954 healthy controls were recruited. The variant rs145204276 was genotyped and the Chi2 test was used to compare the frequency of the genotype and the allele between the patients and the controls. Odds ratio (OR) and 95% confidence intervals (95% CIs) were calculated to estimate the association of rs145204276 with the risk of development and metastasis of GC.
Results |
Patients were found to have significantly lower rate of genotype del/del than the controls (7.2% vs. 8.9%, P=0.016). The allele del was significantly associated with a decreased risk of GC (26.4% vs. 30.7%, P=0.005) with an OR of 0.81 (95% CI=0.70–0.94). Patients with allele del were less likely to develop lymph node metastasis (P=0.01), with an OR of 0.75 (95% CI=0.60–0.93). Comparably, rs145204276 was also significantly associated with a decreased risk of distant metastasis of GC (P=0.007; OR=0.55).
Conclusion |
We confirmed that rs145204276 of GAS5 is a functional variant associated with the susceptibility and metastasis of GC. It plays a protective role in the development of GC possibly through the regulation of GAS5.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Long non-coding RNA, GAS5, Polymorphism, Gastric cancer, Susceptibility
Mappa
Vol 42 - N° 5
P. 478-482 - Ottobre 2018 Ritorno al numero
Articolo precedente
- Crohn's disease treatment practices in France in1999–2013: A prospective survey in non-academic hospitals
- Stéphane Nahon, Pierre Lahmek, Gilles Macaigne, Bruno Lesgourgues, Thierry Paupard
- Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care
- Girish Hiremath, Ellyn Kodroff, Mary J. Strobel, Melissa Scott, Wendy Book, Cathy Reidy, Shay Kyle, Denise Mack, Kathleen Sable, Pablo Abonia, Jonathan Spergel, Sandeep K. Gupta, T. Glenn Furuta, Marc E. Rothenberg, Evan S. Dellon
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?