Case Report: Penile Squamous Cell Carcinoma Associated With Severe Hypercalcemia and High Levels of Parathyroid Hormone-Related Peptide Expressed in Metastatic Skin Tissue - 21/09/18
Abstract |
It is known that high levels of parathyroid hormone-related protein (PTHrP) correlate with a bad prognostic in malignancies. Here we present a patient with advanced penile cancer (PC) without antecedents of human papillomavirus infections and bone metastases but with severe hypercalcemia. By quantitative polymerase chain reaction, we observed high levels of PTHrP messenger RNA in metastatic cutaneous tissue. This is the first reported case in Argentina of hypercalcemia induced by PTHrP in human PC. Furthermore, the association of PTHrP and this disease through quantitative polymerase chain reaction allows us to consider this molecular technique as a novel tool for diagnosis in patients with PC.
Il testo completo di questo articolo è disponibile in PDF.| Financial Disclosure: This study was funded by Agencia Nacional de Promoción Científica y Tecnológica (ANPCYT) (PICT-2013-1441), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (PIP112-201101-00409), Instituto Nacional del Cancer (Resolución Ministerial 493/14; RESOL-2016-1006-E-APN-MS) and Universidad Nacional del Sur (PGI: 24/B188; PGI: 24/B230), Argentina. The funding sources had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. |
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