Can low-dose of ketamine reduce the need for morphine in renal colic? A double-blind randomized clinical trial - 10/03/18

Doi : 10.1016/j.ajem.2017.08.026

Saeed Abbasi, MD ^a,^{^{1
S.A, D.F, and N.B: Idea, Design the study.},}^{^{3
S.A, B.M and N.B: Data collection (visiting the patients, ultrasonography).}}, Nader Bidi, MD ^b,^{^{1
S.A, D.F, and N.B: Idea, Design the study.},}^{^{2
N.B, B.M and P.H: Registering the study in research center of IUMS, Communicating with the manager of hospitals and arrangement of implementation.},}^{^{3
S.A, B.M and N.B: Data collection (visiting the patients, ultrasonography).}} : Emergency Medicine Specialist, Babak Mahshidfar, MD ^a,^{^{2
N.B, B.M and P.H: Registering the study in research center of IUMS, Communicating with the manager of hospitals and arrangement of implementation.},}^{^{3
S.A, B.M and N.B: Data collection (visiting the patients, ultrasonography).}}, Peyman Hafezimoghadam, MD ^a,^{^{2
N.B, B.M and P.H: Registering the study in research center of IUMS, Communicating with the manager of hospitals and arrangement of implementation.},}^{^{4
M.M, P.H: Quality control.}}, Mahdi Rezai, MD ^a,^{^{5
M.R and D.F: Writing the article (search, data bank, primary manuscript).},}^{^{6
M.R, D.F, and M.M: Analysis by SPSS and finalizing the article.}} , Mani Mofidi, MD ^a,^{^{4
M.M, P.H: Quality control.},}^{^{6
M.R, D.F, and M.M: Analysis by SPSS and finalizing the article.}}, Davood Farsi, MD ^a,^{^⁎,}^{^{1
S.A, D.F, and N.B: Idea, Design the study.},}^{^{5
M.R and D.F: Writing the article (search, data bank, primary manuscript).},}^{^{6
M.R, D.F, and M.M: Analysis by SPSS and finalizing the article.},}^{^{7
D.F: takes responsibility for the paper as a whole.}}
^a Emergency Medicine management research center, Iran University of Medical Sciences, Tehran, Iran
^b Emergency Department, Iran University of Medical Sciences, Iran

^⁎Corresponding author at: Hazrat-e-Rasool Akram Hospital, Niayesh St., Sattarkhan St., Tehran, Iran.Hazrat-e-Rasool Akram HospitalNiayesh St., Sattarkhan St.TehranIran

Abstract

Background

The combination of morphine with low doses of ketamine (MK) has been utilized in the Emergency Department (ED) compared with morphine and placebo (MP) for the treatment of acute pain in few studies. The purpose of this study was to compare the effect of MP with MK for the treatment of severe pain with renal colic of patients who had been referred to the ED.

Methods

This study is a double blind randomized clinical trial on patients with severe renal colic pain who were referred to the ED. Patients were enrolled with pain severity of at least 6 of the 10 visual analogue scales (VAS). Patients were divided into two groups: Morphine 0.1mg/kg and placebo (MP group) and morphine 0.1mg/kg and ketamine 0.15mg/kg (MK group). Pain of patients was studied in 10, 30, 60, 90, and 120min after injection.

Results

Totally, 106 patients were enrolled in study groups. Assessment of the average pain during 120min at 10 and 30min after the start in the drug, MK group was significantly lower than the MP group (p=0.019 and p=0.003 respectively).

Conclusion

Given that combinations of morphine with low doses of ketamine in patients with renal colic pain causes more pain and morphine consumption reduction then this combination is suggested as an alternative treatment that could be utilized in patients with renal colic.

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Keywords : Pain, Renal colic, Morphine, Ketamine

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Introduction

Materials and methods

Study design, setting, and selection of participants

☆	The authors have no financial or other conflicts of interest related to the submission. Registration number: (IRCT201109297667N1).

Esportazione

Vol 36 - N° 3

P. 376-379 - Marzo 2018 Ritorno al numero

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Can low-dose of ketamine reduce the need for morphine in renal colic? A double-blind randomized clinical trial - 10/03/18

Abstract

Background

Methods

Results

Conclusion

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