Ten-year clinical outcomes after sirolimus-eluting stent implantation: Impact of an in-stent restenosis target lesion - 12/05/16
, Kazushige Kadota, MD, PhD, Seiji Habara, MD, Hiroshi Miyawaki, MD, Takenobu Shimada, MD, Masanobu Ohya, MD, Hidewo Amano, MD, Yu Izawa, MD, Yusuke Hyodo, MD, Suguru Otsuru, MD, Daiji Hasegawa, MD, Takeshi Tada, MD, PhD, Hiroyuki Tanaka, MD, Yasushi Fuku, MD, Tsuyoshi Goto, MD, Kazuaki Mitsudo, MDBackground |
Little is known about the long-term outcomes after first-generation sirolimus-eluting stent (SES) implantation. We aimed to investigate the clinical outcomes up to 10 years after SES implantation.
Methods |
The study population comprised 342 patients (504 lesions) who underwent SES implantation between January 2002 and December 2004. The median duration of follow-up was 3816 days (interquartile range [Q1-Q3], 3,705-3,883 days).
Results |
The cumulative event rate of definite stent thrombosis was 3.9%. The cumulative rate of target lesion revascularization (TLR) at 1, 5, and 10 years was 8.7%, 18.8%, and 31.1%, respectively, and the annual rate of TLR was 3.1%. Clinically driven TLR occurred at relatively constant rate during 10 years (2.0% per year). In a multivariate analysis, higher body mass index, hemodialysis, in-stent restenosis (ISR) target lesion, and total stent length >30 mm were independent risk factors of TLR within 5 years. An independent risk factor of TLR beyond 5 years was ISR target lesion.
Conclusions |
Late TLR after SES implantation is a long-term hazard, lasting up to 10 years. The ISR target lesion is a risk factor of TLR during 10 years.
Il testo completo di questo articolo è disponibile in PDF.Mappa
Vol 175
P. 47-55 - Maggio 2016 Ritorno al numero
Articolo precedente
- Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry
- Anna Gundlund, Emil Loldrup Fosbøl, Sunghee Kim, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Elaine Hylek, Kenneth W. Mahaffey, Laine Thomas, Jonathan P. Piccini, Eric D. Peterson, ORBIT-AF Investigators
- Risk and timing of recurrent ischemic events among patients with stable ischemic heart disease, non–ST-segment elevation acute coronary syndrome, and ST-segment elevation myocardial infarction
- Thomas Pilgrim, Pascal Vranckx, Marco Valgimigli, Giulio G. Stefanini, Raffaele Piccolo, Julie Rat, Martina Rothenbühler, Stefan Stortecky, Lorenz Räber, Stefan Blöchlinger, Lukas Hunziker, Sigmund Silber, Peter Jüni, Patrick W. Serruys, Stephan Windecker
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?