Persistent symptoms following concussion can be debilitating for patients and challenging for clinicians; however, evidence-based approaches to symptom management are emerging. The presentation of postconcussion syndrome can be variable among patients. Given this variability, a thorough history and physical examination are necessary to tailor an individualized treatment approach. Pharmacologic interventions can be considered when prolonged symptoms are negatively affecting quality of life. This article reviews evidence available to guide such treatment decisions.