Autophagy in alcoholic liver disease, self-eating triggered by drinking - 29/09/15
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Summary |
Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cellular function and also plays critical roles in the etiology and pathogenesis of a number of human diseases. In alcohol-induced liver disease, autophagy is a protective mechanism against the liver injury caused by alcohol. Autophagy is activated in acute ethanol treatment but could be suppressed in chronic and/or high dose treatment of alcohol. The selective removal of lipid droplets and/or damaged mitochondria is likely the major mode of autophagy in reducing liver injury. Understanding the dynamics of the autophagy process and the approach to modulate autophagy could help finding new ways to battle against alcohol-induced liver injury.
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| ☆ | This article is part of the special issue “Alcohol, Virus and Steatosis evolving to cancer” featuring the conference papers of the 10th International Symposium organized by the Brazilian Society of Hepatology in São Paulo, Brazil, September 30th–October 1st, 2015. |
Vol 39 - N° S1
P. S2-S6 - Settembre 2015 Ritorno al numero
Articolo precedente
- ALPD 2015, Preface
- Edna Strauss, Edison Roberto Parise, Hidekazu Tsukamoto
- Combination therapy: New hope for alcoholic hepatitis?
- Bin Gao, Vijay H. Shah
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