Índice

• • ·Cover 1

    Página :OFC

    
• • ·Brief Overview of This Month's JACI

    Página :A3

    
• • ·Table of Contents

    Página :A5

    
• • ·Editorial Board

    Página :A32

    

• Reader services

  • ·Information for Readers

    Página :A34

    
  • ·News & Notes

    Página :A36

    Esquema Esquema  
  • ·Continuing Medical Education Calendar

    Página :A41

    Esquema Esquema

• Reviews and feature articles

  • ·Airway smooth muscle pathophysiology in asthma

    Página :1983-1995

    Blanca Camoretti-Mercado, Richard F. Lockey

    Resumen Resumen Esquema Esquema  
  • ·Airway smooth muscle pathophysiology in asthma

    Página :1996

    
  • ·What is the contribution of IgE to nasal polyposis?

    Página :1997-2008

    Claus Bachert, Marcus Maurer, Oscar Palomares, William W. Busse

    Resumen Resumen Esquema Esquema  
  • ·The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities

    Página :2009-2020

    Christina D. Chambers, Jerry A. Krishnan, Lorene Alba, Jessica D. Albano, Allison S. Bryant, Melanie Carver, Lee S. Cohen, Elena Gorodetsky, Sonia Hernandez-Diaz, Margaret A. Honein, Bridgette L. Jones, Richard K. Murray, Jennifer A. Namazy, Leyla Sahin, Catherine Y. Spong, Kaveeta P. Vasisht, Kevin Watt, Keele E. Wurst, Lynne Yao, Michael Schatz

    Resumen Resumen Esquema Esquema  
  • ·Structures and functions of the inflammasome engine

    Página :2021-2029

    Longfei Wang, Humayun Sharif, Setu M. Vora, Yumei Zheng, Hao Wu

    Resumen Resumen Esquema Esquema  
  • ·Dissecting the complexity of ?? T-cell subsets in skin homeostasis, inflammation, and malignancy

    Página :2030-2042

    Raquel Castillo-González, Danay Cibrian, Francisco Sánchez-Madrid

    Resumen Resumen Esquema Esquema  
  • ·Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference

    Página :2043-2052

    Jason Gotlib, Tracy I. George, Melody C. Carter, K. Frank Austen, Bruce Bochner, Daniel F. Dwyer, Jonathan J. Lyons, Matthew J. Hamilton, Joseph Butterfield, Patrizia Bonadonna, Catherine Weiler, Stephen J. Galli, Lawrence B. Schwartz, Hanneke Oude Elberink, Anne Maitland, Theoharis Theoharides, Celalettin Ustun, Hans-Peter Horny, Alberto Orfao, Michael Deininger, Deepti Radia, Mohamad Jawhar, Hanneke Kluin-Nelemans, Dean D. Metcalfe, Michel Arock, Wolfgang R. Sperr, Peter Valent, Mariana Castells, Cem Akin

    Resumen Resumen Esquema Esquema  

• The Editors' choice

  • ·The Editors’ Choice

    Página :2053-2057

    Esquema Esquema  

• News beyond our pages

  • ·News Beyond Our Pages

    Página :2058-2059

    Marc E. Rothenberg, Jean Bousquet

    Esquema Esquema  

• Paradigms and perspectives

  • ·Role of the NLRP3 inflammasome in asthma: Relationship with neutrophilic inflammation, obesity, and therapeutic options

    Página :2060-2062

    Evan J. Williams, Netsanet A. Negewo, Katherine J. Baines

     
  • ·Memory-type pathogenic T_H2 cells and ILC2s in type 2 allergic inflammation

    Página :2063-2066

    Kiyoshi Hirahara, Ami Aoki, Masahiro Kiuchi, Toshinori Nakayama

     

• Editorials

  • ·Hyperpolarized noble gas MRI of the chest in asthma: No longer an answer in need of a question

    Página :2067-2068

    W. Gerald Teague

     
  • ·Adult peanut allergy: What we know and what we need to learn

    Página :2069-2072

    Soheila J. Maleki, Suzanne S. Teuber, S. Shahzad Mustafa

    Esquema Esquema
  • ·Mast cells to dendritic cells: Let IL-13 shut your IL-12 down

    Página :2073-2074

    Theoharis C. Theoharides, Pio Conti

     

• COVID-19

  • ·Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines

    Página :2075

    Kimberly A. Risma, Kathryn M. Edwards, Donna S. Hummell, Frederic F. Little, Allison E. Norton, Amy Stallings, Robert A. Wood, Joshua D. Milner

    Resumen Resumen Esquema Esquema  
  • ·C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia

    Página :2083

    Wilfried Posch, Jonathan Vosper, Asma Noureen, Viktoria Zaderer, Christina Witting, Giulia Bertacchi, Ronald Gstir, Przemyslaw A. Filipek, Günther K. Bonn, Lukas A. Huber, Rosa Bellmann-Weiler, Cornelia Lass-Flörl, Doris Wilflingseder

    Resumen Resumen Esquema Esquema  
  • ·Distinct cytokine profiles associated with COVID-19 severity and mortality

    Página :2098-2107

    Karim Dorgham, Paul Quentric, Mehmet Gökkaya, Stéphane Marot, Christophe Parizot, Delphine Sauce, Amélie Guihot, Charles-Edouard Luyt, Matthieu Schmidt, Julien Mayaux, Alexandra Beurton, Loic Le Guennec, Sophie Demeret, Elyes Ben Salah, Alexis Mathian, Hans Yssel, Béhazine Combadiere, Christophe Combadiere, Claudia Traidl-Hoffmann, Sonia Burrel, Anne-Geneviève Marcelin, Zahir Amoura, Guillaume Voiriot, Avidan U. Neumann, Guy Gorochov

    Resumen Resumen Esquema Esquema   

• Asthma and lower airway disease

  • ·Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma

    Página :2108-2117

    Yoshihiko Raita, Carlos A. Camargo, Yury A. Bochkov, Juan C. Celedón, James E. Gern, Jonathan M. Mansbach, Eugene P. Rhee, Robert J. Freishtat, Kohei Hasegawa

    Resumen Resumen Esquema Esquema   
  • ·GM-CSF instigates a dendritic cell–T-cell inflammatory circuit that drives chronic asthma development

    Página :2118

    Samuel Philip Nobs, Lea Pohlmeier, Fengqi Li, Merve Kayhan, Burkhard Becher, Manfred Kopf

    Resumen Resumen Esquema Esquema  
  • ·NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

    Página :2134

    Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J. White, Cassandra R. Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat-Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J. Calleja, Jay C. Horvat, Phil M. Hansbro, Robert J.J. O’Donoghue, Jenny P. Ting, Esteban G. Burchard, Matthias Geyer, Motti Gerlic, Seth L. Masters

    Resumen Resumen Esquema Esquema  
  • ·¹²⁹Xe MRI as a measure of clinical disease severity for pediatric asthma

    Página :2146

    Nancy Y. Lin, David J. Roach, Matthew M. Willmering, Laura L. Walkup, Md Monir Hossain, Priyanka Desirazu, Zackary I. Cleveland, Theresa W. Guilbert, Jason C. Woods

    Resumen Resumen Esquema Esquema  
  • ·Peripheral and proximal lung ventilation in asthma: Short-term variation and response to bronchodilator inhalation

    Página :2154

    Helen Marshall, J. Chris Kenworthy, Felix C. Horn, Steven Thomas, Andrew J. Swift, Salman Siddiqui, Christopher E. Brightling, Jim M. Wild

    Resumen Resumen Esquema Esquema  
  • ·Developing and evaluating a pediatric asthma severity computable phenotype derived from electronic health records

    Página :2162-2170

    Komal Peer, William G. Adams, Aaron Legler, Megan Sandel, Jonathan I. Levy, Renée Boynton-Jarrett, Chanmin Kim, Jessica H. Leibler, M. Patricia Fabian

    Resumen Resumen Esquema Esquema   
  • ·Combined exposure to heavy metals in PM_2.5 and pediatric asthma

    Página :2171

    Chia-Yun Hsieh, Chau-Ren Jung, Chuan-Yao Lin, Bing-Fang Hwang

    Resumen Resumen Esquema Esquema  
  • ·COPD-associated miR-145-5p is downregulated in early-decline FEV₁ trajectories in childhood asthma

    Página :2181-2190

    Anshul Tiwari, Jiang Li, Alvin T. Kho, Maoyun Sun, Quan Lu, Scott T. Weiss, Kelan G. Tantisira, Michael J. McGeachie

    Resumen Resumen Esquema Esquema   

• Rhinitis, sinusitis, and ocular allergy

  • ·Chronic rhinosinusitis with nasal polyps is associated with impaired TMEM16A-mediated epithelial chloride secretion

    Página :2191

    Johanna J. Salomon, Tobias Albrecht, Simon Y. Graeber, Heike Scheuermann, Simone Butz, Jolanthe Schatterny, Heimo Mairbäurl, Ingo Baumann, Marcus A. Mall

    Resumen Resumen Esquema Esquema  

• Atopic dermatitis and inflammatory skin disease

  • ·JAK1/2 inhibition impairs the development and function of inflammatory dendritic epidermal cells in atopic dermatitis

    Página :2202

    Anna Sophie Klaeschen, Tim Joachim Nümm, Nadine Herrmann, Nicole Leib, Laura Maintz, Takashi Sakai, Joerg Wenzel, Thomas Bieber

    Resumen Resumen Esquema Esquema  
  • ·Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa

    Página :2213-2224

    Kristina Navrazhina, John W. Frew, Patricia Gilleaudeau, Mary Sullivan-Whalen, Sandra Garcet, James G. Krueger

    Resumen Resumen Esquema Esquema   
  • ·Cross-talk between IFN-? and TWEAK through miR-149 amplifies skin inflammation in psoriasis

    Página :2225-2235

    Ankit Srivastava, Longlong Luo, Warangkana Lohcharoenkal, Florian Meisgen, Lorenzo Pasquali, Andor Pivarcsi, Enikö Sonkoly

    Resumen Resumen Esquema Esquema   
  • ·Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors

    Página :2236

    Xueke Li, Haifeng Yang, Yuewen Han, Shijin Yin, Bingzheng Shen, Yingliang Wu, Wenxin Li, Zhijian Cao

    Resumen Resumen Esquema Esquema  

• Food allergy and gastrointestinal disease

  • ·Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis

    Página :2249

    Nandinee Patel, Daniel C. Adelman, Katherine Anagnostou, Joseph L. Baumert, W. Marty Blom, Dianne E. Campbell, R. Sharon Chinthrajah, E.N. Clare Mills, Bushra Javed, Natasha Purington, Benjamin C. Remington, Hugh A. Sampson, Alexander D. Smith, Ross A.R. Yarham, Paul J. Turner

    Resumen Resumen Esquema Esquema  
  • ·Prevalence and characteristics of peanut allergy in US adults

    Página :2263

    Christopher Warren, Dawn Lei, Scott Sicherer, Robert Schleimer, Ruchi Gupta

    Resumen Resumen Esquema Esquema  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·The efficacy of omalizumab treatment in chronic spontaneous urticaria is associated with basophil phenotypes

    Página :2271

    Kirti J. Johal, Kristin L. Chichester, Eric T. Oliver, Kelly C. Devine, Anja P. Bieneman, John T. Schroeder, Donald W. MacGlashan, Sarbjit S. Saini

    Resumen Resumen Esquema Esquema  

• Mechanisms of allergy/immunology

  • ·Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model

    Página :2281

    Anika Habener, Christine Happle, Ruth Grychtol, Jelena Skuljec, Mandy Busse, Kathleen Dalüge, Helena Obernolte, Katherina Sewald, Armin Braun, Almut Meyer-Bahlburg, Gesine Hansen

    Resumen Resumen Esquema Esquema  
  • ·Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab

    Página :2295

    Donald MacGlashan, Sarbjit Saini, John T. Schroeder

    Resumen Resumen Esquema Esquema  
  • ·Mast cell–derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the T_H1 cell response to cutaneous antigen exposure

    Página :2305

    Juan Manuel Leyva-Castillo, Mrinmoy Das, Emilie Artru, Juhan Yoon, Claire Galand, Raif S. Geha

    Resumen Resumen Esquema Esquema  
  • ·Combination blockade of OX40L and CD30L inhibits allergen-driven memory T_H2 cell reactivity and lung inflammation

    Página :2316-2329

    Donald T. Gracias, Gurupreet S. Sethi, Amit K. Mehta, Haruka Miki, Rinkesh K. Gupta, Hideo Yagita, Michael Croft

    Resumen Resumen Esquema Esquema  
  • ·Fc?R1-expressing nociceptors trigger allergic airway inflammation

    Página :2330-2342

    Theo Crosson, Jo-Chiao Wang, Benjamin Doyle, Hannah Merrison, Mohammad Balood, Alexandre Parrin, Maud Pascal, Barbara C. Mindt, Corey R. Seehus, Alp Ozcan, Xuan Huang, Elise Semenara, Nicole Y.Y. Lai, Abdelilah Majdoubi, Raja-Elie E. Abdulnour, Trevor Rajchgot, Moutih Rafei, Simmie L. Foster, Jacques Thibodeau, Jörg H. Fritz, Bruce D. Levy, Clifford J. Woolf, Sebastien Talbot

    Resumen Resumen Esquema Esquema   
  • ·HCMV-controlling NKG2C⁺ NK cells originate from novel circulating inflammatory precursors

    Página :2343-2357

    Federica Bozzano, Mariella Della Chiesa, Andrea Pelosi, Francesca Antonini, Maria Libera Ascierto, Genny Del Zotto, Francesca Moretta, Letizia Muccio, Anna Luganini, Giorgio Gribaudo, Giovanni Cenderello, Chiara Dentone, Laura Nicolini, Alessandro Moretta, Lorenzo Moretta, Andrea De Maria

    Resumen Resumen Esquema Esquema   

• Translational and clinical immunology

  • ·Immunophenotyping in pemphigus reveals a T_H17/T_FH17 cell–dominated immune response promoting desmoglein1/3-specific autoantibody production

    Página :2358-2369

    Julia Holstein, Farzan Solimani, Carolin Baum, Katharina Meier, Robert Pollmann, Dario Didona, Tobias Tekath, Martin Dugas, Nicolas Casadei, Christoph Hudemann, Alexandra Polakova, Jakob Matthes, Iris Schäfer, Amir S. Yazdi, Rüdiger Eming, Michael Hertl, Wolfgang Pfützner, Kamran Ghoreschi, Christian Möbs

    Resumen Resumen Esquema Esquema   
  • ·Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8⁺ T cells in autoimmunity and cancer

    Página :2370-2380

    Jared Liu, Hsin-Wen Chang, Zhi-Ming Huang, Mio Nakamura, Sahil Sekhon, Richard Ahn, Priscila Munoz-Sandoval, Shrishti Bhattarai, Kristen M. Beck, Isabelle M. Sanchez, Eric Yang, Mariela Pauli, Sarah T. Arron, Wai-Ping Fung-Leung, Ernesto Munoz, Xuejun Liu, Tina Bhutani, Jeffrey North, Anne M. Fourie, Michael D. Rosenblum, Wilson Liao

    Resumen Resumen Esquema Esquema   

• Brief reports

  • ·Defective neutrophil development and specific granule deficiency caused by a homozygous splice-site mutation in SMARCD2

    Página :2381

    Ina Schim van der Loeff, Evelien G.G. Sprenkeler, Anton T.J. Tool, Mario Abinun, Angela Grainger, Karin R. Engelhardt, Michel van Houdt, Hans Janssen, Taco W. Kuijpers, Sophie Hambleton

    Resumen Resumen Esquema Esquema  
  • ·Sequestosome 1/p62 enhances chronic skin inflammation

    Página :2386

    Supawadee Sukseree, Latifa Bakiri, Marta Palomo-Irigoyen, Özge Uluçkan, Peter Petzelbauer, Erwin F. Wagner

    Resumen Resumen Esquema Esquema  

• Corrigenda

  • ·Corrigenda

    Página :2394

     
  • ·Corrigendum

    Página :2394

    
  • ·Corrigendum

    Página :2395-2396

     
  • ·Corrigendum

    Página :2397-2398

     

• Errata

  • ·Errata

    Página :2399

     
  • ·Erratum

    Página :2400