Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·Continuing Medical Education Calendar

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• Reviews and feature articles

  • ·Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

    Página :925-937

    Peter A. Nigrovic, Pui Y. Lee, Hal M. Hoffman

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  • ·Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

    Página :938-939

    
  • ·Cytokine release syndrome and neurotoxicity following CAR T-cell therapy for hematologic malignancies

    Página :940-948

    Craig W. Freyer, David L. Porter

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  • ·Highways to hell: Mechanism-based management of cytokine storm syndromes

    Página :949-959

    Scott W. Canna, Randy Q. Cron

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  • ·Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist

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    Lori Broderick, Hal M. Hoffman

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  • ·Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

    Página :967-983

    Emilia Cirillo, Giuliana Giardino, Silvia Ricci, Viviana Moschese, Vassilios Lougaris, Francesca Conti, Chiara Azzari, Federica Barzaghi, Clementina Canessa, Baldassarre Martire, Raffaele Badolato, Laura Dotta, Annarosa Soresina, Caterina Cancrini, Andrea Finocchi, Davide Montin, Roberta Romano, Donato Amodio, Francesca Ferrua, Alberto Tommasini, Lucia Augusta Baselli, Rosa Maria Dellepiane, Agata Polizzi, Luciana Chessa, Antonio Marzollo, Maria Pia Cicalese, Maria Caterina Putti, Andrea Pession, Alessandro Aiuti, Franco Locatelli, Alessandro Plebani, Claudio Pignata

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  • ·In lasting tribute: Charles E. Reed, March 13, 1922, to July 24, 2020

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    Robert K. Bush, William W. Busse, James T. Li

     

• The Editors' choice

  • ·The Editors’ Choice

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    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

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    Marc E. Rothenberg, Jean Bousquet

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• Beyond the frontiers

  • ·eNose breathprints as composite biomarker for real-time phenotyping of complex respiratory diseases

    Página :995-996

    Rianne de Vries, Peter J. Sterk

     

• Paradigms and perspectives

  • ·The systemic autoinflammatory diseases: Coming of age with the human genome

    Página :997-1001

    Deborah L. Stone, David B. Beck, Kalpana Manthiram, Yong Hwan Park, Jae Jin Chae, Elaine Remmers, Daniel L. Kastner

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  • ·Fasting, dietary restriction, and immunosenescence

    Página :1002-1004

    Valter D. Longo, Salvatore Cortellino

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  • ·Dietary patterns in childhood and their effect on gut microbiota—an Asian perspective on atopy risk

    Página :1005-1007

    Intan Hakimah Ismail, Christophe Lay, Noorizan H.A. Majid, Way Seah Lee, Bee Wah Lee, Amir Hamzah Abdul Latiff, Hern Tze Tina Tan, Jan Knol, Yeong Yeh Lee

     

• Editorials

  • ·Acetaminophen and asthma, a bitter pill to swallow?

    Página :1008-1009

    Anders Bjerg

    
  • ·Predicting atopic asthma by using eNose breath profiles with machine learning

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    Wei Wu

     
  • ·It’s that time of year—APRIL promotes humoral immunity in humans

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    Stuart G. Tangye

     

• Asthma and lower airway disease

  • ·Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma

    Página :1016-1026

    Juliana Durack, Laura S. Christian, Snehal Nariya, Jeanmarie Gonzalez, Nirav R. Bhakta, K. Mark Ansel, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, Elliot Israel, Monica Kraft, Richard J. Martin, David T. Mauger, Stephen P. Peters, Sharon R. Rosenberg, Christine A. Sorkness, Michael E. Wechsler, Sally E. Wenzel, Steven R. White, Susan V. Lynch, Homer A. Boushey, Yvonne J. Huang, National Heart, Lung, and Blood Institute’s ”AsthmaNet“

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  • ·Asthma among hospitalized patients with COVID-19 and related outcomes

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    Stephanie Lovinsky-Desir, Deepti R. Deshpande, Aliva De, Laurie Murray, Jeanette A. Stingone, Angela Chan, Neha Patel, Nooralam Rai, Emily DiMango, Joshua Milner, Meyer Kattan

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  • ·Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort

    Página :1035

    Xin Dai, Shyamali C. Dharmage, Michael J. Abramson, Bircan Erbas, Catherine M. Bennett, Cecilie Svanes, Jennie Hui, Christine Axelrad, Adrian J. Lowe, Caroline J. Lodge

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  • ·eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy

    Página :1045-1055

    Mahmoud I. Abdel-Aziz, Paul Brinkman, Susanne J.H. Vijverberg, Anne H. Neerincx, Rianne de Vries, Yennece W.F. Dagelet, John H. Riley, Simone Hashimoto, Paolo Montuschi, Kian Fan Chung, Ratko Djukanovic, Louise J. Fleming, Clare S. Murray, Urs Frey, Andrew Bush, Florian Singer, Gunilla Hedlin, Graham Roberts, Sven-Erik Dahlén, Ian M. Adcock, Stephen J. Fowler, Karen Knipping, Peter J. Sterk, Aletta D. Kraneveld, Anke H. Maitland-van der Zee, U-BIOPRED Study Group, Amsterdam UMC Breath Research Group

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• Atopic dermatitis and inflammatory skin disease

  • ·Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis

    Página :1056-1069

    Thomas B. Rojahn, Vera Vorstandlechner, Thomas Krausgruber, Wolfgang M. Bauer, Natalia Alkon, Christine Bangert, Felix M. Thaler, Farzaneh Sadeghyar, Nikolaus Fortelny, Victoria Gernedl, Katharina Rindler, Adelheid Elbe-Bürger, Christoph Bock, Michael Mildner, Patrick M. Brunner

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  • ·Targeting inducible costimulator expressed on CXCR5⁺PD-1⁺ T_H cells suppresses the progression of pemphigus vulgaris

    Página :1070

    A Reum Kim, Dawoon Han, Ji Young Choi, Joon Seok, Song-Ee Kim, Seong-Hoon Seo, Hayato Takahashi, Masayuki Amagai, Su-Hyung Park, Soo-Chan Kim, Eui-Cheol Shin, Jong Hoon Kim

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• Food allergy and gastrointestinal disease

  • ·Early epitope-specific IgE antibodies are predictive of childhood peanut allergy

    Página :1080-1088

    Maria Suprun, Scott H. Sicherer, Robert A. Wood, Stacie M. Jones, Donald Y.M. Leung, Alice K. Henning, Peter Dawson, A. Wesley Burks, Robert Lindblad, Robert Getts, Mayte Suárez-Fariñas, Hugh A. Sampson

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• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Persistent, refractory, and biphasic anaphylaxis: A multidisciplinary Delphi study

    Página :1089-1096

    Timothy E. Dribin, Hugh A. Sampson, Carlos A. Camargo, David C. Brousseau, Jonathan M. Spergel, Mark I. Neuman, Marcus Shaker, Ronna L. Campbell, Kenneth A. Michelson, Susan A. Rudders, Amal H. Assa’ad, Kimberly A. Risma, Mariana Castells, Lynda C. Schneider, Julie Wang, Juhee Lee, Rakesh D. Mistry, David Vyles, Lisa M. Vaughn, Daniel J. Schumacher, John K. Witry, Shiv Viswanathan, Erica M. Page, David Schnadower

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• Biologics and immunotherapy

  • ·Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy

    Página :1097-1108

    Azahara Rodríguez-Domínguez, Margot Berings, Alexander Rohrbach, Huey-Jy Huang, Mirela Curin, Philippe Gevaert, Paolo M. Matricardi, Rudolf Valenta, Susanne Vrtala

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• Mechanisms of allergy/immunology

  • ·APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans

    Página :1109

    Tzu-Wen Yeh, Tsubasa Okano, Takuya Naruto, Motoi Yamashita, Miko Okamura, Kay Tanita, Likun Du, Qiang Pan-Hammarström, Noriko Mitsuiki, Satoshi Okada, Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio

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  • ·Bcl6 and Blimp1 reciprocally regulate ST2⁺ Treg–cell development in the context of allergic airway inflammation

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    Byunghee Koh, Benjamin J. Ulrich, Andrew S. Nelson, Gayathri Panangipalli, Rakshin Kharwadkar, Wenting Wu, Markus M. Xie, Yongyao Fu, Matthew J. Turner, Sophie Paczesny, Sarath Chandra Janga, Alexander L. Dent, Mark H. Kaplan

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  • ·CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow

    Página :1137-1151

    Lena Fischer-Riepe, Niklas Daber, Jonas Schulte-Schrepping, Bruna Caroline Véras De Carvalho, Antonella Russo, Michele Pohlen, Josephine Fischer, Achmet Imam Chasan, Marc Wolf, Thomas Ulas, Shirin Glander, Christian Schulz, Boris Skryabin, Andreas Wollbrink, Dipl-Ing, Nadine Steingraeber, Christopher Stremmel, Megan Koehle, Florian Gärtner, Sabine Vettorazzi, Dirk Holzinger, Joachim Gross, Frank Rosenbauer, Monika Stoll, Silke Niemann, Jan Tuckermann, Joachim L. Schultze, Johannes Roth, Katarzyna Barczyk-Kahlert

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  • ·RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis

    Página :1152

    Gordon S. Wong, Jamie L. Redes, Nariman Balenga, Morgan McCullough, Nathalie Fuentes, Ameya Gokhale, Cynthia Koziol-White, Joseph A. Jude, Laura A. Madigan, Eunice C. Chan, William H. Jester, Sabrina Biardel, Nicolas Flamand, Reynold A. Panettieri, Kirk M. Druey

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• Translational and clinical immunology

  • ·Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

    Página :1165

    Rosita Rigoni, Elena Fontana, Kerry Dobbs, Veronica Marrella, Valentina Taverniti, Virginia Maina, Amanda Facoetti, Giovanna D’Amico, Waleed Al-Herz, Mario Ernesto Cruz-Munoz, Catharina Schuetz, Andrew R. Gennery, Elizabeth K. Garabedian, Silvia Giliani, Deborah Draper, Ghassan Dbaibo, Raif S. Geha, Isabelle Meyts, Thomas Tousseyn, Benedicte Neven, Despina Moshous, Alain Fischer, Ansgar Schulz, Andrea Finocchi, Douglas B. Kuhns, Danielle L. Fink, Michail S. Lionakis, Muthulekha Swamydas, Simone Guglielmetti, Julie Alejo, Ian A. Myles, Stefania Pittaluga, Luigi D. Notarangelo, Anna Villa, Barbara Cassani

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  • ·Defective Sec61?1 underlies a novel cause of autosomal dominant severe congenital neutropenia

    Página :1180-1193

    Erika Van Nieuwenhove, John S. Barber, Julika Neumann, Elien Smeets, Mathijs Willemsen, Emanuela Pasciuto, Teresa Prezzemolo, Vasiliki Lagou, Laura Seldeslachts, Bert Malengier-Devlies, Mieke Metzemaekers, Sarah Haßdenteufel, Axelle Kerstens, Rob van der Kant, Frederic Rousseau, Joost Schymkowitz, Daniele Di Marino, Sven Lang, Richard Zimmermann, Susan Schlenner, Sebastian Munck, Paul Proost, Patrick Matthys, Christine Devalck, Nancy Boeckx, Frank Claessens, Carine Wouters, Stephanie Humblet-Baron, Isabelle Meyts, Adrian Liston

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• Brief report

  • ·Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1

    Página :1194

    Pui Y. Lee, Craig D. Platt, Sabrina Weeks, Rachael F. Grace, George Maher, Kasey Gauthier, Sridevi Devana, Sally Vitali, Adrienne G. Randolph, Douglas R. McDonald, Raif S. Geha, Janet Chou

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• Letters to the Editor

  • ·A toxic palmitoylation of Cdc42 enhances NF-?B signaling and drives a severe autoinflammatory syndrome

    Página :1201

    Bahia Bekhouche, Aurore Tourville, Yamini Ravichandran, Rachida Tacine, Laurence Abrami, Michael Dussiot, Andrea Khau-Dancasius, Olivia Boccara, Meriem Khirat, Marianne Mangeney, Florent Dingli, Damarys Loew, Batiste Boëda, Pénélope Jordan, Thierry Jo Molina, Nathalia Bellon, Sylvie Fraitag, Smail Hadj-Rabia, Stéphane Blanche, Anne Puel, Sandrine Etienne-Manneville, F. Gisou van der Goot, Jacqueline Cherfils, Olivier Hermine, Jean-Laurent Casanova, Christine Bodemer, Asma Smahi, Jérôme Delon

     
  • ·A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)

    Página :1204

    Bin Lin, Roberta Berard, Abdulrahman Al Rasheed, Buthaina Aladba, Philip J. Kranzusch, Maggie Henderlight, Alexi Grom, Dana Kahle, Sofia Torreggiani, Alexander G. Aue, Jacob Mitchell, Adriana A. de Jesus, Grant S. Schulert, Raphaela Goldbach-Mansky

     
  • ·A rare case of selective Ig? chain deficiency: Biologic and clinical implications

    Página :1208

    Amir A. Sadighi Akha, Renee C. Tschumper, John R. Mills, Crescent R. Isham, Elizabeth E. Witty, David S. Viswanatha, Surendra Dasari, Melissa R. Snyder, David L. Murray, Jerry A. Katzmann, Diane F. Jelinek, Maria A.V. Willrich

     
  • ·The regulatory activity of autophagy in conjunctival fibroblasts and its possible role in vernal keratoconjunctivitis

    Página :1210

    Paola Brun, Elena Tarricone, Antonino Di Stefano, Elena Mattiuzzo, Parvaneh Mehrbod, Saeid Ghavami, Andrea Leonardi

     
  • ·COVID-19: Start with the nose

    Página :1214

    Brian Lipworth, Rory Chan, Chris RuiWen Kuo

    
  • ·Reply

    Página :1214-1215

    Daniel J. Jackson, William W. Busse, Alkis Togias, James E. Gern, Mathew C. Altman

    
  • ·Corrigenda

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  • ·Corrigendum

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