Índice

• • ·Cover 1

    Página :OFC

    
• • ·Brief Overview of This Month's JACI

    Página :A5

    
• • ·Table of Contents

    Página :A7

    
• • ·Editorial Board

    Página :A30

    

• Reviews and feature articles

  • ·Biologics for chronic rhinosinusitis with nasal polyps

    Página :725-739

    Claus Bachert, Nan Zhang, Carlo Cavaliere, Wen Weiping, Elien Gevaert, Olga Krysko

    Resumen Resumen Esquema Esquema  
  • ·Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

    Página :740-750

    Tetsuji Takabayashi, Robert P. Schleimer

    Resumen Resumen Esquema Esquema  
  • ·Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

    Página :751

    
  • ·Endotypes of chronic rhinosinusitis: Impact on management

    Página :752-756

    Lars-Olaf Cardell, Pär Stjärne, Karin Jonstam, Claus Bachert

    Resumen Resumen Esquema Esquema  
  • ·An expert consensus framework for asthma remission as a treatment goal

    Página :757-765

    Andrew Menzies-Gow, Mona Bafadhel, William W. Busse, Thomas B. Casale, Janwillem W.H. Kocks, Ian D. Pavord, Stanley J. Szefler, Prescott G. Woodruff, Alexander de Giorgio-Miller, Frank Trudo, Malin Fageras, Christopher S. Ambrose

    Resumen Resumen Esquema Esquema   

• The Editors' choice

  • ·The Editors’ Choice

    Página :766-770

    Zuhair K. Ballas, Associate Editors of the JACI

    Esquema Esquema  

• News beyond our pages

  • ·News Beyond Our Pages

    Página :771-772

    Marc E. Rothenberg, Jean Bousquet

    Esquema Esquema  

• Paradigms and perspectives

  • ·The sense of smell in chronic rhinosinusitis

    Página :773-776

    Joaquim Mullol, Franklin Mariño-Sánchez, Meritxell Valls, Isam Alobid, Concepció Marin

    Esquema Esquema  
  • ·Genetics of chronic rhinosinusitis

    Página :777-779

    Kyle B. Mitts, Eugene H. Chang

    Esquema Esquema  

• Editorials

  • ·Immunologic dysfunction and Hodgkin lymphoma: Insight to better therapy?

    Página :780-781

    Brian K. Link

     
  • ·Metabolomics and allergy: Opening Pandora’s box

    Página :782-784

    François Spertini

     
  • ·New paradigm of B-cell biology regarding the elucidation of a new mechanism of tissue fibrosis in IgG₄-related disease

    Página :785-787

    Hiroshi Nakase, Keisuke Ishigami

     
  • ·2019: The year in review

    Página :788-790

    Zuhair K. Ballas

    

• Asthma and lower airway disease

  • ·Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

    Página :791

    Ane Johannessen, Marianne Lønnebotn, Lucia Calciano, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Shyamali Dharmage, Karl A. Franklin, Thorarinn Gislason, Mathias Holm, Christer Janson, Deborah Jarvis, Rain Jõgi, Jeong-Lim Kim, Jorunn Kirkeleit, Caroline Lodge, Andrei Malinovschi, Jesus Martinez-Moratalla, Roy Miodini Nilsen, Antonio Pereira-Vega, Francisco Gómez Real, Vivi Schlünssen, Simone Accordini, Cecilie Svanes

    Resumen Resumen Esquema Esquema  
  • ·Prenatal polyunsaturated fatty acids and child asthma: Effect modification by maternal asthma and child sex

    Página :800

    Maria José Rosa, Terryl J. Hartman, Margaret Adgent, Kourtney Gardner, Tebeb Gebretsadik, Paul E. Moore, Robert L. Davis, Kaja Z. LeWinn, Nicole R. Bush, Frances Tylavsky, Rosalind J. Wright, Kecia N. Carroll

    Resumen Resumen Esquema Esquema  
  • ·IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

    Página :808

    Martijn L. Manson, Jesper Säfholm, Anna James, Anna-Karin Johnsson, Per Bergman, Mamdoh Al-Ameri, Ann-Charlotte Orre, Carina Kärrman-Mårdh, Sven-Erik Dahlén, Mikael Adner

    Resumen Resumen Esquema Esquema  
  • ·Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue

    Página :818

    Thomas Bärnthaler, Anna Theiler, Diana Zabini, Sandra Trautmann, Elvira Stacher-Priehse, Ilse Lanz, Walter Klepetko, Katharina Sinn, Holger Flick, Stefan Scheidl, Dominique Thomas, Horst Olschewski, Grazyna Kwapiszewska, Rufina Schuligoi, Akos Heinemann

    Resumen Resumen Esquema Esquema  

• Rhinitis, sinusitis, and ocular allergy

  • ·Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

    Página :834

    Emilie Burte, Bénédicte Leynaert, Alessandro Marcon, Jean Bousquet, Meriem Benmerad, Roberto Bono, Anne-Elie Carsin, Kees de Hoogh, Bertil Forsberg, Frederic Gormand, Joachim Heinrich, Jocelyne Just, Mark Nieuwenhuijsen, Isabelle Pin, Morgane Stempfelet, Jordi Sunyer, Simona Villani, Nino Künzli, Valérie Siroux, Deborah Jarvis, Rachel Nadif, Bénédicte Jacquemin

    Resumen Resumen Esquema Esquema  
  • ·Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis

    Página :843

    Takeshi Tsuda, Masayuki Nishide, Yohei Maeda, Yoshitomo Hayama, Shohei Koyama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Takayoshi Morita, Takeshi Nakatani, Yasuhiro Kato, Yoshimitsu Nakanishi, Yu Futami, Yasuhiko Suga, Yujiro Naito, Hachiro Konaka, Shingo Satoh, Maiko Naito, Mayuko Izumi, Sho Obata, Ayaka Nakatani, Takashi Shikina, Kazuya Takeda, Masaki Hayama, Hidenori Inohara, Atsushi Kumanogoh

    Resumen Resumen Esquema Esquema  
  • ·Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis

    Página :855

    Ya-Qi Peng, Zi-Li Qin, Shu-Bin Fang, Zhi-Bin Xu, Hong-Yu Zhang, Dong Chen, Zheng Liu, Joseph A. Bellanti, Song Guo Zheng, Qing-Ling Fu

    Resumen Resumen Esquema Esquema  

• Atopic dermatitis and inflammatory skin disease

  • ·Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study

    Página :868-876

    Meena Rafiq, Andrew Hayward, Charlotte Warren-Gash, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Georgios Lyratzopoulos, Sara Thomas

    Resumen Resumen Esquema Esquema   
  • ·Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial

    Página :877-884

    Emma Guttman-Yassky, Diamant Thaçi, Aileen L. Pangan, H. Chih-ho Hong, Kim A. Papp, Kristian Reich, Lisa A. Beck, Mohamed-Eslam F. Mohamed, Ahmed A. Othman, Jaclyn K. Anderson, Yihua Gu, Henrique D. Teixeira, Jonathan I. Silverberg

    Resumen Resumen Esquema Esquema   

• Food allergy and gastrointestinal disease

  • ·Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE

    Página :885

    Mindy Tsai, Kaori Mukai, R. Sharon Chinthrajah, Kari C. Nadeau, Stephen J. Galli

    Resumen Resumen Esquema Esquema  
  • ·Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

    Página :897-906

    Elena Crestani, Hani Harb, Louis-Marie Charbonnier, Jonathan Leirer, Alison Motsinger-Reif, Rima Rachid, Wanda Phipatanakul, Rima Kaddurah-Daouk, Talal A. Chatila

    Resumen Resumen Esquema Esquema   

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Rapid desensitization of humanized mice with anti-human Fc?RI? monoclonal antibodies

    Página :907

    Marat V. Khodoun, Suzanne C. Morris, Elizabeth Angerman, Crystal Potter, Richard Schuman, Mark Wunderlich, Joseph J. Maciag, Kathryn C. Sullivan Locker, James C. Mulloy, Andrew B. Herr, Fred D. Finkelman

    Resumen Resumen Esquema Esquema  

• Biologics and immunotherapy

  • ·Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis

    Página :922-932

    Lewis E. Tomalin, Chris B. Russell, Sandra Garcet, David Adrian Ewald, Paul Klekotka, Ajay Nirula, Hanne Norsgaard, Mayte Suàrez-Fariñas, James G. Krueger

    Resumen Resumen Esquema Esquema   

• Mechanisms of allergy/immunology

  • ·Dichotomous role of TGF-? controls inducible regulatory T-cell fate in allergic airway disease through Smad3 and TGF-?–activated kinase 1

    Página :933

    Anthony Joetham, Michaela Schedel, Fangkun Ning, Meiqin Wang, Katsuyuki Takeda, Erwin W. Gelfand

    Resumen Resumen Esquema Esquema  
  • ·Identifying regulatory pathways of spleen tyrosine kinase expression in human basophils

    Página :947-957

    Xia Peng, Mingming Zhao, Li Gao, Ranjan Sen, Donald MacGlashan

    Resumen Resumen Esquema Esquema   
  • ·Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation

    Página :958

    Sergio Villazala-Merino, Azahara Rodriguez-Dominguez, Victoria Stanek, Nicholas J. Campion, Pia Gattinger, Gerhard Hofer, Renate Froeschl, Ingrid Fae, Christian Lupinek, Susanne Vrtala, Heimo Breiteneder, Walter Keller, Thomas Perkmann, Ryosuke Nakamura, Winfried F. Pickl, Rudolf Valenta, Julia Eckl-Dorna, Verena Niederberger

    Resumen Resumen Esquema Esquema  

• Translational and clinical immunology

  • ·B lymphocytes directly contribute to tissue fibrosis in patients with IgG₄-related disease

    Página :968

    Emanuel Della-Torre, Elena Rigamonti, Cory Perugino, Simona Baghai-Sain, Na Sun, Naoki Kaneko, Takashi Maehara, Lucrezia Rovati, Maurilio Ponzoni, Raffaella Milani, Marco Lanzillotta, Vinay Mahajan, Hamid Mattoo, Ivan Molineris, Vikram Deshpande, John H. Stone, Massimo Falconi, Angelo A. Manfredi, Shiv Pillai

    Resumen Resumen Esquema Esquema  
  • ·Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome

    Página :982-992

    Genay O. Pilarowski, Tareian Cazares, Li Zhang, Joel S. Benjamin, Ke Liu, Sajjeev Jagannathan, Nadeem Mousa, Jennifer Kasten, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson

    Resumen Resumen Esquema Esquema   

• Environmental and occupational disease

  • ·Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence

    Página :993-1001

    Angela Simpson, Helen A. Brough, Sadia Haider, Danielle Belgrave, Clare S. Murray, Adnan Custovic

    Resumen Resumen Esquema Esquema   

• Letters to the Editor

  • ·Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP)

    Página :1002

    Yi Wei, Jia Zhang, Xingmei Wu, Wei Sun, Fanqin Wei, Wendong Liu, Tong Lu, Weidong Ji, Huabin Li, Weiping Wen

     
  • ·Intralymphatic immunotherapy in pollen-allergic young adults with rhinoconjunctivitis and mild asthma: A randomized trial

    Página :1005

    Jon R. Konradsen, Jeanette Grundström, Laila Hellkvist, Thi Anh Thu Tran, Niklas Andersson, Guro Gafvelin, M.B. Gea Kiewiet, Carl Hamsten, Jiaqian Tang, Rebecca V. Parkin, Mohamed H. Shamji, Gunilla Hedlin, Lars-Olaf Cardell, Marianne van Hage

     
  • ·Defining a new immune deficiency syndrome: MAN2B2-CDG

    Página :1008-1011

    Jan Verheijen, Sunnie Y. Wong, Jared H. Rowe, Kimiyo Raymond, Jennifer Stoddard, Ottavia M. Delmonte, Marita Bosticardo, Kerry Dobbs, Julie Niemela, Enrica Calzoni, Sung-Yun Pai, Uimook Choi, Yasuhiro Yamazaki, Anne Marie Comeau, Erin Janssen, Lauren Henderson, Melissa Hazen, Gerard Berry, Sergio D. Rosenzweig, Hasan Hamdan Aldhekri, Miao He, Luigi D. Notarangelo, Eva Morava

      
  • ·Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency

    Página :1011

    Amit Nahum, Nigel Sharfe, Arnon Broides, Harjit Dadi, Zahra Naghdi, Amarilla B. Mandola, Linda Vong, Adi Arbiv, Ilan Dalal, Ido Brami, Ohad Wormser, Jacov Levy, Chaim M. Roifman

     
  • ·PSMB10, the last immunoproteasome gene missing for PRAAS

    Página :1015

    Guillaume Sarrabay, Déborah Méchin, Aicha Salhi, Guilaine Boursier, Cécile Rittore, Yanick Crow, Gillian Rice, Tu-Anh Tran, Renaud Cezar, Darragh Duffy, Vincent Bondet, Lakhdar Boudhane, Christophe Broca, Benjamin P. Kant, Mariëlle VanGijn, Sylvie Grandemange, Eric Richard, Florence Apparailly, Isabelle Touitou

     
  • ·Germline gain-of-function mutation of STAT1 rescued by somatic mosaicism in immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like disorder

    Página :1017-1021

    Jeong Seok Lee, Yohan An, Christopher J. Yoon, Jeong Yeon Kim, Kyung Hwan Kim, Alexandra F. Freeman, Jae-Joon Yim, Eui-Cheol Shin, Steven M. Holland, Eun Young Lee, Young Seok Ju

      
  • ·T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis

    Página :1021

    Consol Farrera, Rossella Melchiotti, Nedyalko Petrov, Karen Wei Weng Teng, Michael Thomas Wong, Chiew Yee Loh, Federica Villanova, Isabella Tosi, Jinmiao Chen, Katarzyna Grys, Hemawtee Sreeneebus, Anna Chapman, Gayathri K. Perera, Susanne Heck, Filipe Gracio, Emanuele de Rinaldis, Jonathan N. Barker, Catherine H. Smith, Frank O. Nestle, Evan W. Newell, Paola Di Meglio

     
  • ·Electronic vapor products, marijuana use, smoking, and asthma in US adolescents

    Página :1025

    Yueh-Ying Han, Franziska Rosser, Erick Forno, Juan C. Celedón

     

• Correspondence

  • ·The panorama in diagnoses of severe combined immunodeficiency begins to change in Brazil

    Página :1029

    Juliana Mazzucchelli, Carolina Sanchez Aranda, Mariana Gouveia-Pereira, Lucila Akune Barreiros, Beatriz Tavares Costa Carvalho, Antonio Condino-Neto, Maria Isabel de Moraes-Pinto

    
  • ·Reply

    Página :1029-1030

    Juan Carlos Bustamante Ogando

    

• Corrigendum

  • ·Corrigendum

    Página :1030

    

• Reader services

  • ·Information for Readers

    Página :A32

    
  • ·News & Notes

    Página :A38

    Esquema Esquema  
  • ·Continuing Medical Education Calendar

    Página :A43

    Esquema Esquema