Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reviews and feature articles

  • ·Pruritus in allergy and immunology

    Página :353-360

    Ting-Lin B. Yang, Brian S. Kim

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  • ·Pruritus in allergy and immunology

    Página :361

    
  • ·The skin as an immune organ: Tolerance versus effector responses and applications to food allergy and hypersensitivity reactions

    Página :362-374

    Emma Guttman-Yassky, Lisa Zhou, James G. Krueger

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  • ·Itching as a systemic disease

    Página :375-380

    Takashi Hashimoto, Gil Yosipovitch

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  • ·Advances in drug allergy, urticaria, angioedema, and anaphylaxis in 2018

    Página :381-392

    Rachel L. Miller, Maria Shtessel, Lacey B. Robinson, Aleena Banerji

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• The Editors' choice

  • ·The Editors’ Choice

    Página :393-394

    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Página :395-396

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Reconciling breast-feeding and early food introduction guidelines in the prevention and management of food allergy

    Página :397

    Merryn J. Netting, Katrina J. Allen

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• Editorials

  • ·Asthma causation and the gastrointestinal microbiome and metabolome: Might there be a signal, or is it just noise?

    Página :401-403

    Richard Hansen, Kostas Gerasimidis, Steve Turner

     
  • ·Exposure: Staphylococcus aureus skin colonization predisposes to food allergy in the Learning Early about Allergy to Peanut (LEAP) and LEAP-On studies

    Página :404-406

    Joan M. Cook-Mills, Mark H. Kaplan, Matthew J. Turner, Kirsten M. Kloepfer, Rajesh Kumar

     
  • ·Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine

    Página :407-409

    Hannah J. Gould, Louisa K. James

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  • ·A role for maternal IgG in protecting infants from allergen-specific IgE sensitization

    Página :410-412

    Harry W. Schroeder

     
  • ·Strength in numbers: The quest for asthma genes

    Página :413-415

    Donata Vercelli, Eugene R. Bleecker

     

• Asthma and lower airway disease

  • ·Loss of bronchoprotection with ICS plus LABA treatment, ?-receptor dynamics, and the effect of alendronate

    Página :416

    Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A. Boushey, Mario Castro, Vernon M. Chinchilli, Christopher D. Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F. Lemanske, Njira Lugogo, Dave Mauger, Wendy C. Moore, James Moy, Victor E. Ortega, Stephen P. Peters, Lewis J. Smith, Julian Solway, Christine A. Sorkness, Kaharu Sumino, Michael E. Wechsler, Sally Wenzel, Elliot Israel, AsthmaNet Investigators

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  • ·Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1? secretion by bronchoalveolar fluid macrophages from asthmatic subjects

    Página :426

    Elizabeth M. Gordon, Xianglan Yao, Haitao Xu, William Karkowsky, Maryann Kaler, Or Kalchiem-Dekel, Amisha V. Barochia, Meixia Gao, Karen J. Keeran, Kenneth R. Jeffries, Stewart J. Levine

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  • ·Integrative analysis of the intestinal metabolome of childhood asthma

    Página :442-454

    Kathleen A. Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua

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• Rhinitis, sinusitis, and ocular allergy

  • ·Epithelium-derived cystatin SN enhances eosinophil activation and infiltration through IL-5 in patients with chronic rhinosinusitis with nasal polyps

    Página :455-469

    Bing Yan, Hongfei Lou, Yang Wang, Ying Li, Yifan Meng, Sihan Qi, Ming Wang, Lei Xiao, Chengshuo Wang, Luo Zhang

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• Atopic dermatitis and inflammatory skin disease

  • ·EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

    Página :470-481

    Martina S. Elias, Sheila C. Wright, Judit Remenyi, James C. Abbott, Susan E. Bray, Christian Cole, Sharon Edwards, Marek Gierlinski, Mateusz Glok, John A. McGrath, William V. Nicholson, Lavinia Paternoster, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown

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  • ·GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis

    Página :482

    Emma Guttman-Yassky, Ana B. Pavel, Lisa Zhou, Yeriel D. Estrada, Ning Zhang, Hui Xu, Xiangyu Peng, Huei-Chi Wen, Panayiota Govas, Girish Gudi, Vinu CA, Hui Fang, Yacine Salhi, Jonathan Back, Venkateshwar Reddy, Robert Bissonnette, Catherine Maari, Fred Grossman, Gerhard Wolff

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• Food allergy and gastrointestinal disease

  • ·Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity

    Página :494-503

    Olympia Tsilochristou, George du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson, Michelle L. Sever, Henry T. Bahnson, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack

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• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy

    Página :504

    Robert Heddle, Anthony Smith, Richard Woodman, Pravin Hissaria, Nikolai Petrovsky

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• Biologics and immunotherapy

  • ·Role of the IgE variable heavy chain in Fc?RI? and superantigen binding in allergy and immunotherapy

    Página :514

    Wai-Heng Lua, Chinh Tran-To Su, Joshua Yi Yeo, Jun-Jie Poh, Wei-Li Ling, Ser-Xian Phua, Samuel Ken-En Gan

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• Mechanisms of allergy/immunology

  • ·Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE

    Página :524

    Caroline Galeotti, Emmanuel Stephen-Victor, Anupama Karnam, Mrinmoy Das, Laurent Gilardin, Mohan S. Maddur, Sandra Wymann, Cédric Vonarburg, Alain Chevailler, Jordan D. Dimitrov, Olivier Benveniste, Pierre Bruhns, Srini V. Kaveri, Jagadeesh Bayry

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  • ·Maternal allergen-specific IgG might protect the child against allergic sensitization

    Página :536-548

    Christian Lupinek, Heidrun Hochwallner, Catharina Johansson, Axel Mie, Eva Rigler, Annika Scheynius, Johan Alm, Rudolf Valenta

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  • ·Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology

    Página :549

    Damon Tumes, Kiyoshi Hirahara, Magdalene Papadopoulos, Kenta Shinoda, Atsushi Onodera, Jin Kumagai, Kwok Ho Yip, Harshita Pant, Kota Kokubo, Masahiro Kiuchi, Ami Aoki, Kazushige Obata-Ninomiya, Koji Tokoyoda, Yusuke Endo, Motoko Y. Kimura, Toshinori Nakayama

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  • ·Endothelial Sox17 promotes allergic airway inflammation

    Página :561

    Eun Hee Ha, Jun-Pyo Choi, Hyouk-Soo Kwon, Hyeung Ju Park, Sang Joon Lah, Keun-Ai Moon, Seung-Hyo Lee, Injune Kim, You Sook Cho

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• Translational and clinical immunology

  • ·Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency

    Página :574

    Mohammed F. Alosaimi, Manfred Hoenig, Faris Jaber, Craig D. Platt, Jennifer Jones, Jacqueline Wallace, Klaus-Michael Debatin, Ansgar Schulz, Eva Jacobsen, Peter Möller, Hanan E. Shamseldin, Ferdous Abdulwahab, Niema Ibrahim, Hosam Alardati, Faisal Almuhizi, Ibraheem F. Abosoudah, Talal A. Basha, Janet Chou, Fowzan S. Alkuraya, Raif S. Geha

    Resumen Resumen Esquema Esquema  
  • ·Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies

    Página :584

    Cinzia Milito, Federica Pulvirenti, Francesco Cinetto, Vassilios Lougaris, Annarosa Soresina, Antonio Pecoraro, Alessandra Vultaggio, Maria Carrabba, Giuseppe Lassandro, Alessandro Plebani, Giuseppe Spadaro, Andrea Matucci, Giovanna Fabio, Rosa Maria Dellepiane, Baldassarre Martire, Carlo Agostini, Damiano Abeni, Stefano Tabolli, Isabella Quinti

    Resumen Resumen Esquema Esquema  

• Letters to the Editor

  • ·Adjuvant haploidentical virus-specific T lymphocytes for treatment of disseminated adenovirus infection in a premature infant

    Página :594

    Jeffery J. Auletta, Pablo J. Sánchez, Erin K. Meyer, Lynn C. O'Donnell, Kevin A. Cassady, Christopher P. Ouellette, Shaina Hecht, Alejandro Diaz, Leeann R. Pavlek, Douglas P. Salamon, Christina L. Gallagher, Hillary Bradbury, Sarah L. Welfley, Jacqueline Magers, Debra L. Armbruster, Margaret G. Lamb, Robin J. Nakkula, Kevin Bosse, Dean A. Lee

     
  • ·Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species–independent manner

    Página :597

    Atul Sharma, Katelyn McCann, Jitendra Kumar Tripathi, Pooja Chauhan, Christa Zerbe, Bibhuti B. Mishra, Steven M. Holland, Jyotika Sharma

     
  • ·Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions

    Página :600

    Sam Mehr, Eric Lee, Peter Hsu, Denise Anderson, Emma de Jong, Anthony Bosco, Dianne E. Campbell

     
  • ·?-Arrestin2 expressed in mast cells regulates ciprofloxacin-induced pseudoallergy and IgE-mediated anaphylaxis

    Página :603-606

    Saptarshi Roy, Kshitij Gupta, Anirban Ganguly, Hydar Ali

      
  • ·Combined immunodeficiency in a patient with c-Rel deficiency

    Página :606

    Sarah Beaussant-Cohen, Faris Jaber, Michel J. Massaad, Sabrina Weeks, Jennifer Jones, Mohammed F. Alosaimi, Jacqueline Wallace, Waleed Al-Herz, Raif S. Geha, Janet Chou

     
  • ·Virus-specific T-cell clonotypes might contribute to drug hypersensitivity reactions through heterologous immunity

    Página :608

    Coral-Ann Almeida, Paula van Miert, Kane O'Driscoll, Yvonne M. Zoet, Abha Chopra, Campbell Witt, Mina John, Frans H.J. Claas, Lloyd J. D'Orsogna

     
  • ·A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis

    Página :611

    Mohammed F. Alosaimi, Michelle C. Maciag, Craig D. Platt, Raif S. Geha, Janet Chou, Lisa M. Bartnikas

     
  • ·GATA-2–deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects

    Página :613

    Avanti Desai, Kathryn Sowerwine, Yihui Liu, Monica G. Lawrence, Jack Chovanec, Amy P. Hsu, Michael P. O'Connell, Jiwon Kim, Lisa Boris, Nina Jones, Laura Wisch, Robin R. Eisch, Melody C. Carter, Hirsh D. Komarow, Christa Zerbe, Joshua D. Milner, Irina Maric, Xiaoping Sun, Chyi-Chia R. Lee, Ilker Tunc, Mehdi Pirooznia, Kelly D. Stone, Steven M. Holland, Dean D. Metcalfe, Jonathan J. Lyons

     
  • ·Murine neonatal skin mast cells are phenotypically immature and minimally sensitized with transplacentally transferred IgE

    Página :617

    Yuki Honda, Sachiko Ono, Tetsuya Honda, Tatsuki R. Kataoka, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Saeko Nakajima, Takashi Nomura, Teruki Dainichi, Kenji Kabashima

     

• Correspondence

  • ·Mepolizumab in patients with eosinophilic granulomatosis with polyangiitis

    Página :621

    Sergey Moiseev, Eugenia Zagvozdkina, Viktoria Kazarina, Nikolai Bulanov, Pavel Novikov

    
  • ·Reply

    Página :622

    Michael E. Wechsler, Isabelle Pouliquen, Jonathan Steinfeld, Eric S. Bradford, MIRRA study team

    
  • ·Basophil histamine release in patients with chronic spontaneous urticaria: Optimize or minimize

    Página :622-623

    Allen P. Kaplan

    
  • ·Reply

    Página :623-624

    Donald MacGlashan

    
  • ·Grandmaternal smoking during pregnancy and asthma in grandchildren

    Página :624

    Lennart Bråbäck, David Olsson, Bertil Forsberg

    
  • ·Reply

    Página :624-625

    Toril Mørkve Knudsen, Faisal I. Rezwan, Cecilie Svanes, John W. Holloway

    

• Corrigenda

  • ·Corrigenda

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  • ·Corrigenda

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·Continuing Medical Education Calendar

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