Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·Continuing Medical Education Calendar

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• Reviews and feature articles

  • ·Biomarkers in connective tissue diseases

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    Neelakshi R. Jog, Judith A. James

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  • ·Biomarkers in connective tissue diseases

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  • ·Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

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    Mohamed H. Shamji, Stephen R. Durham

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  • ·Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

    Página :1499-1508

    Jose Gurrola, Larry Borish

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  • ·Biomarkers for severe eosinophilic asthma

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    Steven W. Yancey, Oliver N. Keene, Frank C. Albers, Hector Ortega, Stewart Bates, Eugene R. Bleecker, Ian Pavord

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  • ·Graphic depiction of bioinformatics data

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    Agustin Calatroni, Jeremy J. Wildfire

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  • ·Pathogenic CD4⁺ T cells in patients with asthma

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    Lyndsey M. Muehling, Monica G. Lawrence, Judith A. Woodfolk

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• The Editors' choice

  • ·The Editors' Choice

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    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·NEWS Beyond our Pages

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    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Autoinflammatory keratinization diseases

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    Masashi Akiyama, Takuya Takeichi, John A. McGrath, Kazumitsu Sugiura

     

• Editorial

  • ·Autophagy: Nobel Prize 2016 and allergy and asthma research

    Página :1548-1549

    Harald Renz

     

• Asthma and lower airway disease

  • ·Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor ? positive feedback loop in M2 macrophages

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    Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong

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• Rhinitis, sinusitis, and ocular allergy

  • ·Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis

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    Jin-Young Min, Jayakar V. Nayak, Kathryn E. Hulse, Whitney W. Stevens, Paul A. Raju, Julia H. Huang, Lydia A. Suh, Griet A. Van Roey, James E. Norton, Roderick G. Carter, Caroline P.E. Price, Ava R. Weibman, Ali R. Rashan, Eliver E. Ghosn, Zara M. Patel, Tetsuya Homma, David B. Conley, Kevin C. Welch, Stephanie Shintani-Smith, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Atsushi Kato, Peter H. Hwang, Robert C. Kern, Leonore A. Herzenberg, Robert P. Schleimer, Bruce K. Tan

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• Atopic dermatitis and inflammatory skin disease

  • ·IgE sensitization in relation to preschool eczema and filaggrin mutation

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    Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Marianne van Hage, Magnus Wickman, Natalia Ballardini, Carl-Fredrik Wahlgren

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  • ·Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks

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    Sinéad M. Langan, Beth Stuart, Lucy Bradshaw, Jochen Schmitt, Hywel C. Williams, Kim S. Thomas

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• Food allergy and gastrointestinal disease

  • ·Prevalence of food allergies and intolerances documented in electronic health records

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    Warren W. Acker, Joseph M. Plasek, Kimberly G. Blumenthal, Kenneth H. Lai, Maxim Topaz, Diane L. Seger, Foster R. Goss, Sarah P. Slight, David W. Bates, Li Zhou

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  • ·Circulating gluten-specific FOXP3⁺CD39⁺ regulatory T cells have impaired suppressive function in patients with celiac disease

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    Laura Cook, C. Mee Ling Munier, Nabila Seddiki, David van Bockel, Noé Ontiveros, Melinda Y. Hardy, Jana K. Gillies, Megan K. Levings, Hugh H. Reid, Jan Petersen, Jamie Rossjohn, Robert P. Anderson, John J. Zaunders, Jason A. Tye-Din, Anthony D. Kelleher

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• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Lifelong memory responses perpetuate humoral T_H2 immunity and anaphylaxis in food allergy

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    Rodrigo Jiménez-Saiz, Derek K. Chu, Talveer S. Mandur, Tina D. Walker, Melissa E. Gordon, Roopali Chaudhary, Joshua Koenig, Sarah Saliba, Heather J. Galipeau, Adam Utley, Irah L. King, Kelvin Lee, Rachel Ettinger, Susan Waserman, Roland Kolbeck, Manel Jordana

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• Biologics and immunotherapy

  • ·Neonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A randomized clinical trial

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    Lisbeth Marianne Thøstesen, Lone Graff Stensballe, Gitte Thybo Pihl, Jesper Kjærgaard, Nina Marie Birk, Thomas Nørrelykke Nissen, Aksel Karl Georg Jensen, Peter Aaby, Annette Wind Olesen, Dorthe Lisbeth Jeppesen, Christine Stabell Benn, Poul-Erik Kofoed

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• Mechanisms of allergy/immunology

  • ·Advances in mechanisms of allergic disease in 2016

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    Marc E. Rothenberg, Hirohisa Saito, R. Stokes Peebles

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  • ·Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)–mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

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    Susanne Radonjic-Hoesli, Xiaoliang Wang, Elisabeth de Graauw, Christina Stoeckle, Beata Styp-Rekowska, Ruslan Hlushchuk, Dagmar Simon, Peter J. Spaeth, Shida Yousefi, Hans-Uwe Simon

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• Translational and clinical immunology

  • ·Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation

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    Rick Admiraal, Coco C.H. de Koning, Caroline A. Lindemans, Marc B. Bierings, Annemarie M.J. Wensing, A. Birgitta Versluys, Tom F.W. Wolfs, Stefan Nierkens, Jaap Jan Boelens

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  • ·Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function

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    Craig D. Platt, Janet Chou, Patrick Houlihan, Yousef R. Badran, Lalit Kumar, Wayne Bainter, P. Luigi Poliani, Carlos J. Perez, Sharon Y.R. Dent, David E. Clapham, Fernando Benavides, Raif S. Geha

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  • ·Thymus transplantation for complete DiGeorge syndrome: European experience

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    E. Graham Davies, Melissa Cheung, Kimberly Gilmour, Jesmeen Maimaris, Joe Curry, Anna Furmanski, Neil Sebire, Neil Halliday, Konstantinos Mengrelis, Stuart Adams, Jolanta Bernatoniene, Ronald Bremner, Michael Browning, Blythe Devlin, Hans Christian Erichsen, H. Bobby Gaspar, Lizzie Hutchison, Winnie Ip, Marianne Ifversen, T. Ronan Leahy, Elizabeth McCarthy, Despina Moshous, Kim Neuling, Malgorzata Pac, Alina Papadopol, Kathryn L. Parsley, Luigi Poliani, Ida Ricciardelli, David M. Sansom, Tiia Voor, Austen Worth, Tessa Crompton, M. Louise Markert, Adrian J. Thrasher

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  • ·Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-?B activation and leads to incontinentia pigmenti

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    Elodie Bal, Emmanuel Laplantine, Yamina Hamel, Virginie Dubosclard, Bertrand Boisson, Alessandra Pescatore, Capucine Picard, Smaïl Hadj-Rabia, Ghislaine Royer, Julie Steffann, Jean-Paul Bonnefont, Valeria M. Ursini, Pierre Vabres, Arnold Munnich, Jean-Laurent Casanova, Christine Bodemer, Robert Weil, Fabrice Agou, Asma Smahi

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• Environmental and occupational disease

  • ·Advances in environmental and occupational disorders in 2016

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    William J. Sheehan, Jonathan M. Gaffin, David B. Peden, Robert K. Bush, Wanda Phipatanakul

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• Epidemiology and health care delivery

  • ·Sensitization trajectories in childhood revealed by using a cluster analysis

    Página :1693-1699

    Ann-Marie M. Schoos, Bo L. Chawes, Erik Melén, Anna Bergström, Inger Kull, Magnus Wickman, Klaus Bønnelykke, Hans Bisgaard, Morten A. Rasmussen

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• Letters to the Editor

  • ·Cleaved kininogen as a biomarker for bradykinin release in hereditary angioedema

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    Zonne L.M. Hofman, Steven de Maat, Chiara Suffritti, Andrea Zanichelli, Cassandra van Doorn, Silvie A.E. Sebastian, Nora Veszeli, Dorottya Csuka, Thomas Renné, Gerard Pasterkamp, Marco Cicardi, Henriette Farkas, C. Erik Hack, Coen Maas

     
  • ·EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients

    Página :1703-1705

    Judith L. Thijs, Julia Drylewicz, Renée Fiechter, Ian Strickland, Matthew A. Sleeman, Athula Herath, Richard D. May, Catharina A.F.M. Bruijnzeel-Koomen, Edward F. Knol, Barbara Giovannone, Marjolein S. de Bruin-Weller, Stefan Nierkens, Dirk Jan Hijnen

      
  • ·Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps

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    Karin Jonstam, Marit Westman, Gabriële Holtappels, Cecile T.J. Holweg, Claus Bachert

     
  • ·Relationship between EASI and SCORAD severity assessments for atopic dermatitis

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    Rishi Chopra, Paras P. Vakharia, Ryan Sacotte, Neha Patel, Supriya Immaneni, Takeshia White, Robert Kantor, Derek Y. Hsu, Jonathan I. Silverberg

     
  • ·Responsiveness and minimal important difference of the urticaria control test

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    Tatevik Ohanyan, Nicole Schoepke, Bediha Bolukbasi, Martin Metz, Tomasz Hawro, Torsten Zuberbier, Adriane Peveling-Oberhag, Petra Staubach, Marcus Maurer, Karsten Weller

     
  • ·Association study of childhood food allergy with genome-wide association studies–discovered loci of atopic dermatitis and eosinophilic esophagitis

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    Tomomitsu Hirota, Tsuguhisa Nakayama, Sakura Sato, Noriyuki Yanagida, Teruaki Matsui, Shiro Sugiura, Yuri Takaoka, Nobuyuki Hizawa, Shigeharu Fujieda, Akihiko Miyatake, Takashi Sasaki, Masayuki Amagai, Satoru Doi, Komei Ito, Motohiro Ebisawa, Mayumi Tamari

      
  • ·A randomized, placebo-controlled, double-blinded, crossover trial of pioglitazone for severe asthma

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    Maryann Kaler, Amisha V. Barochia, Nargues A. Weir, Rosemarie A. Cuento, Mario Stylianou, Mark J. Roth, Armando C. Filie, Ellen C. Vaughey, Steven D. Nathan, Stewart J. Levine

      
  • ·Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features

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    Hideaki Morita, Hiroko Suzuki, Kanami Orihara, Kenichiro Motomura, Akio Matsuda, Yukihiro Ohya, Hirohisa Saito, Ichiro Nomura, Kenji Matsumoto

     
  • ·Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation

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    Christian Klemann, Sandra Ammann, Miriam Heizmann, Sebastian Fuchs, Sebastian F. Bode, Maximilian Heeg, Hans Fuchs, Kai Lehmberg, Udo zur Stadt, Claudia Roll, Thomas Vraetz, Carsten Speckmann, Myriam Ricarda Lorenz, Klaus Schwarz, Jan Rohr, Stefan Feske, Stephan Ehl

     
  • ·Distribution of peanut protein in school and home environments of inner-city children

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    William J. Sheehan, Helen A. Brough, Kerry Makinson, Carter R. Petty, Gideon Lack, Wanda Phipatanakul

     
  • ·A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens

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    Vemuri B. Reddy, Thomas A. Graham, Ehsan Azimi, Ethan A. Lerner

      
  • ·Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction

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    Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber

     
  • ·Prevalence of primary immunodeficiencies in France is underestimated

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    Nizar Mahlaoui, Jean-Philippe Jais, Pauline Brosselin, Cecile Mignot, Beatrice Beaurain, Carolina Brito, Laurence Costes, Virginie Courteille, Nathalie De Vergnes, Alexandre Alcaïs, Alain Fischer, CEREDIH Prevalence Study Collaborators ?

      
  • ·Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics

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    Phillip L. Lieberman, Ilisten Jones, Richa Rajwanshi, Karin Rosén, Dale T. Umetsu

     
  • ·A flow cytometry–based diagnosis of eosinophilic esophagitis

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    Ting Wen, Jonathan Kuhl, Philip Putnam, Vincent Mukkada, Michael Farrell, Ajay Kaul, Conrad Cole, Marc E. Rothenberg

     
  • ·Abnormalities of T-cell receptor repertoire in CD4⁺ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity

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    Jared H. Rowe, Brian D. Stadinski, Lauren A. Henderson, Lisa Ott de Bruin, Ottavia Delmonte, Yu Nee Lee, M. Teresa de la Morena, Rakesh K. Goyal, Anthony Hayward, Chiung-Hui Huang, Maria Kanariou, Alejandra King, Taco W. Kuijpers, Jian Yi Soh, Benedicte Neven, Jolan E. Walter, Eric S. Huseby, Luigi D. Notarangelo

     
  • ·T-cell receptor sequencing reveals decreased diversity 18 years after early thymectomy

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    Judith Gudmundsdottir, Christina Lundqvist, Hanna Ijspeert, Eva van der Slik, Sólveig Óskarsdóttir, Susanne Lindgren, Vanja Lundberg, Martin Berglund, Jenny Lingman-Framme, Esbjörn Telemo, Mirjam van der Burg, Olov Ekwall

     
  • ·Natural protective immunity against grass pollen allergy is maintained by a diverse spectrum of response types

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    Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Eva Hattinger, Melanie Lietzenmayer, Yoan Machado, Sandra Scheiblhofer, Angelika Stoecklinger, Theresa Thalhamer, Susanne Suessner, Martin Danzer, Sabine Keplinger, Johannes Weinberger, Susanne Schaller, Stephan Winkler, Christian Gabriel, Josef Thalhamer, Richard Weiss

     
  • ·Increased IgE levels are linked to faster relapse in patients with omalizumab-discontinued chronic spontaneous urticaria

    Página :1749-1751

    Ragip Ertas, Kemal Ozyurt, Emin Ozlu, Yilmaz Ulas, Atil Avci, Mustafa Atasoy, Tomasz Hawro, Marcus Maurer

     
  • ·Food diversity during the first year of life and allergic diseases until 15 years

    Página :1751

    Iana Markevych, Marie Standl, Irina Lehmann, Andrea von Berg, Joachim Heinrich

     
  • ·Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients

    Página :1754

    Aurélien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge Adnot

     
  • ·Correction

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