Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

    Página :3A

    
• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

    Página :34A

    
  • ·News & Notes

    Página :44A

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  • ·CME Activities Calendar

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• Reviews and feature articles

  • ·Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment?

    Página :1071-1081

    Kian Fan Chung

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  • ·Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment

    Página :1082-1083

    
  • ·Correlation between early-life regulation of the immune system by microbiota and allergy development

    Página :1084-1091

    Thomas Gensollen, Richard S. Blumberg

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  • ·Functional relevance of microbiome signatures: The correlation era requires tools for consolidation

    Página :1092-1098

    Ludovica F. Buttó, Dirk Haller

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  • ·The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

    Página :1099-1110

    Yvonne J. Huang, Benjamin J. Marsland, Supinda Bunyavanich, Liam O'Mahony, Donald Y.M. Leung, Antonella Muraro, Thomas A. Fleisher

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  • ·International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

    Página :1111

    Anna Nowak-W?grzyn, Mirna Chehade, Marion E. Groetch, Jonathan M. Spergel, Robert A. Wood, Katrina Allen, Dan Atkins, Sami Bahna, Ashis V. Barad, Cecilia Berin, Terri Brown Whitehorn, A. Wesley Burks, Jean-Christoph Caubet, Antonella Cianferoni, Marisa Conte, Carla Davis, Alessandro Fiocchi, Kate Grimshaw, Ruchi Gupta, Brittany Hofmeister, J.B. Hwang, Yitzhak Katz, George N. Konstantinou, Stephanie A. Leonard, Jennifer Lightdale, Sean McGhee, Sami Mehr, Stefano Miceli Sopo, Giovanno Monti, Antonella Muraro, Stacey Katherine Noel, Ichiro Nomura, Sally Noone, Hugh A. Sampson, Fallon Schultz, Scott H. Sicherer, Cecilia C. Thompson, Paul J. Turner, Carina Venter, A. Amity Westcott-Chavez, Matthew Greenhawt

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• The Editors' choice

  • ·The Editors' Choice

    Página :1127-1128

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Página :1129-1130

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·The National Biome Initiative: An allergy perspective

    Página :1131-1134

    Glenn T. Furuta, Seema S. Aceves

     

• Editorials

  • ·Is epicutaneous immunotherapy only skin deep?

    Página :1135-1136

    Yitzhak Katz, Michael R. Goldberg

    
  • ·Insights into the mast cell–microbiome connection in the skin

    Página :1137-1139

    Alon Y. Hershko

     

• Asthma and lower airway disease

  • ·Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations

    Página :1140

    Rachel Tham, Don Vicendese, Shyamali C. Dharmage, Rob J. Hyndman, Ed Newbigin, Emma Lewis, Molly O'Sullivan, Adrian J. Lowe, Philip Taylor, Philip Bardin, Mimi L.K. Tang, Michael J. Abramson, Bircan Erbas

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  • ·Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

    Página :1148-1157

    Manuel A.R. Ferreira, Rick Jansen, Gonneke Willemsen, Brenda Penninx, Lisa M. Bain, Cristina T. Vicente, Joana A. Revez, Melanie C. Matheson, Jennie Hui, Joyce Y. Tung, Svetlana Baltic, Peter Le Souëf, Grant W. Montgomery, Nicholas G. Martin, Colin F. Robertson, Alan James, Philip J. Thompson, Dorret I. Boomsma, John L. Hopper, David A. Hinds, Rhiannon B. Werder, Simon Phipps, Australian Asthma Genetics Consortium Collaborators ‡

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  • ·Validation of the Global Allergy and Asthma European Network (GA²LEN) chamber for trials in allergy: Innovation of a mobile allergen exposure chamber

    Página :1158-1166

    Torsten Zuberbier, Mark B. Abelson, Cezmi A. Akdis, Claus Bachert, Uwe Berger, Carsten Bindslev-Jensen, Georg Boelke, Jean Bousquet, Giorgio Walter Canonica, Thomas B. Casale, Marek Jutel, Marek L. Kowalski, Enzo Madonini, Nikolaos G. Papadopoulos, Oliver Pfaar, Torsten Sehlinger, Karl-Christian Bergmann, Global Allergy and Asthma European Network (GA2LEN) European Union Network of Excellence in Allergy and Asthma

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  • ·Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma

    Página :1167

    Steven W. Yancey, Hector G. Ortega, Oliver N. Keene, Bhabita Mayer, Necdet B. Gunsoy, Christopher E. Brightling, Eugene R. Bleecker, Pranabashis Haldar, Ian D. Pavord

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  • ·Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations

    Página :1176-1185

    Marina Pretolani, Anders Bergqvist, Gabriel Thabut, Marie-Christine Dombret, Dominique Knapp, Fatima Hamidi, Loubna Alavoine, Camille Taillé, Pascal Chanez, Jonas S. Erjefält, Michel Aubier

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  • ·Pulmonary sarcoidosis is associated with exosomal vitamin D–binding protein and inflammatory molecules

    Página :1186-1194

    Maria-Jose Martinez-Bravo, Casper J.E. Wahlund, Khaleda Rahman Qazi, Robert Moulder, Ana Lukic, Olof Rådmark, Riitta Lahesmaa, Johan Grunewald, Anders Eklund, Susanne Gabrielsson

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• Rhinitis, sinusitis, and upper airway disease

  • ·Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps

    Página :1195

    Jiun-Bo Chen, Louisa K. James, Anna M. Davies, Yu-Chang Bryan Wu, Joanne Rimmer, Valerie J. Lund, Jou-Han Chen, James M. McDonnell, Yih-Chih Chan, George H. Hutchins, Tse Wen Chang, Brian J. Sutton, Harsha H. Kariyawasam, Hannah J. Gould

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• Atopic dermatitis and skin disease

  • ·Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes

    Página :1205

    Zhenping Wang, Nicholas Mascarenhas, Lars Eckmann, Yukiko Miyamoto, Xiaojun Sun, Toshiaki Kawakami, Anna Di Nardo

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  • ·Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders

    Página :1217-1227

    Yun Liang, Xianying Xing, Maria A. Beamer, William R. Swindell, Mrinal K. Sarkar, Liza Wolterink Roberts, John J. Voorhees, J. Michelle Kahlenberg, Paul W. Harms, Andrew Johnston, Johann E. Gudjonsson

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  • ·A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

    Página :1228-1241

    Aishath S. Naeem, Cristina Tommasi, Christian Cole, Stuart J. Brown, Yanan Zhu, Benjamin Way, Saffron A.G. Willis Owen, Miriam Moffatt, William O. Cookson, John I. Harper, Wei-Li Di, Sara J. Brown, Thomas Reinheckel, Ryan F.L. O'Shaughnessy

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• Food, drug, insect sting allergy, and anaphylaxis

  • ·Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults

    Página :1242

    Stacie M. Jones, Scott H. Sicherer, A. Wesley Burks, Donald Y.M. Leung, Robert W. Lindblad, Peter Dawson, Alice K. Henning, M. Cecilia Berin, David Chiang, Brian P. Vickery, Robbie D. Pesek, Christine B. Cho, Wendy F. Davidson, Marshall Plaut, Hugh A. Sampson, Robert A. Wood, Consortium of Food Allergy Research

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  • ·Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

    Página :1253

    Caitlin M. Gillis, Friederike Jönsson, David A. Mancardi, Naxin Tu, Héloïse Beutier, Nico Van Rooijen, Lynn E. Macdonald, Andrew J. Murphy, Pierre Bruhns

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  • ·Mast cells are associated with the onset and progression of celiac disease

    Página :1266

    Barbara Frossi, Claudio Tripodo, Carla Guarnotta, Antonio Carroccio, Marco De Carli, Stefano De Carli, Marco Marino, Antonino Calabrò, Carlo E. Pucillo

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• Immune deficiencies, infection, and systemic immune disorders

  • ·Physical health conditions and quality of life in adults with primary immunodeficiency diagnosed during childhood: A French Reference Center for PIDs (CEREDIH) study

    Página :1275

    Vincent Barlogis, Nizar Mahlaoui, Pascal Auquier, Isabelle Pellier, Fanny Fouyssac, Camille Vercasson, Maya Allouche, Carolina Brito De Azevedo, Felipe Suarez, Despina Moshous, Bénédicte Neven, Marlène Pasquet, Eric Jeziorski, Nathalie Aladjidi, Nicolas Schleinitz, Caroline Thomas, Virginie Gandemer, Françoise Mazingue, Patrick Lutz, Olivier Hermine, Capucine Picard, Stéphane Blanche, Gérard Michel, Alain Fischer

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  • ·Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation

    Página :1282-1292

    M. Teresa de la Morena, David Leonard, Troy R. Torgerson, Otavio Cabral-Marques, Mary Slatter, Asghar Aghamohammadi, Sharat Chandra, Luis Murguia-Favela, Francisco A. Bonilla, Maria Kanariou, Rongras Damrongwatanasuk, Caroline Y. Kuo, Christopher C. Dvorak, Isabelle Meyts, Karin Chen, Lisa Kobrynski, Neena Kapoor, Darko Richter, Daniela DiGiovanni, Fatima Dhalla, Evangelia Farmaki, Carsten Speckmann, Teresa Español, Anna Shcherbina, Imelda Celine Hanson, Jiri Litzman, John M. Routes, Melanie Wong, Ramsay Fuleihan, Suranjith L. Seneviratne, Trudy N. Small, Ales Janda, Liliana Bezrodnik, Reinhard Seger, Andrea Gomez Raccio, J. David M. Edgar, Janet Chou, Jordan K. Abbott, Joris van Montfrans, Luis Ignacio González-Granado, Nancy Bunin, Necil Kutukculer, Paul Gray, Gisela Seminario, Srdjan Pasic, Victor Aquino, Christian Wysocki, Hassan Abolhassani, Morna Dorsey, Charlotte Cunningham-Rundles, Alan P. Knutsen, John Sleasman, Beatriz Tavares Costa Carvalho, Antonio Condino-Neto, Eyal Grunebaum, Helen Chapel, Hans D. Ochs, Alexandra Filipovich, Mort Cowan, Andrew Gennery, Andrew Cant, Luigi D. Notarangelo, Chaim M. Roifman

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  • ·Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice

    Página :1293

    Haifa H. Jabara, John J. Lee, Erin Janssen, Sumana Ullas, Kyriaki Liadaki, Lilit Garibyan, Halli Benson, Tatyana Sannikova, Richard Bram, Lennart Hammarstrom, Anthony C. Cruz, Richard Siegel, John Manis, Richard Malley, Raif S. Geha

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  • ·A prospective study on the natural history of patients with profound combined immunodeficiency: An interim analysis

    Página :1302

    Carsten Speckmann, Sam Doerken, Alessandro Aiuti, Michael H. Albert, Waleed Al-Herz, Luis M. Allende, Alessia Scarselli, Tadej Avcin, Ruy Perez-Becker, Caterina Cancrini, Andrew Cant, Silvia Di Cesare, Andrea Finocchi, Alain Fischer, H. Bobby Gaspar, Sujal Ghosh, Andrew Gennery, Kimberly Gilmour, Luis I. González-Granado, Monica Martinez-Gallo, Sophie Hambleton, Fabian Hauck, Manfred Hoenig, Despina Moshous, Benedicte Neven, Tim Niehues, Luigi Notarangelo, Capucine Picard, Nikolaus Rieber, Ansgar Schulz, Klaus Schwarz, Markus G. Seidel, Pere Soler-Palacin, Polina Stepensky, Brigitte Strahm, Thomas Vraetz, Klaus Warnatz, Christine Winterhalter, Austen Worth, Sebastian Fuchs, Annette Uhlmann, Stephan Ehl, P-CID study of the Inborn Errors Working Party of the EBMT

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  • ·Efficacy and safety of canakinumab in Schnitzler syndrome: A multicenter randomized placebo-controlled study

    Página :1311-1320

    Karoline Krause, Athanasios Tsianakas, Nicola Wagner, Jörg Fischer, Karsten Weller, Martin Metz, Martin K. Church, Marcus Maurer

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• Mechanisms of allergy and clinical immunology

  • ·Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69^?CD56^dim cells

    Página :1321

    Nicole Marquardt, Eliisa Kekäläinen, Puran Chen, Egle Kvedaraite, Jennifer N. Wilson, Martin A. Ivarsson, Jenny Mjösberg, Lena Berglin, Jesper Säfholm, Martijn L. Manson, Mikael Adner, Mamdoh Al-Ameri, Per Bergman, Ann-Charlotte Orre, Mattias Svensson, Barbro Dahlén, Sven-Erik Dahlén, Hans-Gustaf Ljunggren, Jakob Michaëlsson

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  • ·Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways

    Página :1331-1342

    Anthony Joetham, Michaela Schedel, Brian P. O'Connor, Soohyun Kim, Katsuyuki Takeda, Jordan Abbott, Erwin W. Gelfand

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  • ·Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways

    Página :1343

    Katharina Dietz, Marta de los Reyes Jiménez, Eva S. Gollwitzer, Adam M. Chaker, Ulrich M. Zissler, Olof P. Rådmark, Hoeke A. Baarsma, Melanie Königshoff, Carsten B. Schmidt-Weber, Benjamin J. Marsland, Julia Esser-von Bieren

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  • ·T-bet inhibits innate lymphoid cell–mediated eosinophilic airway inflammation by suppressing IL-9 production

    Página :1355

    Ayako Matsuki, Hiroaki Takatori, Sohei Makita, Masaya Yokota, Tomohiro Tamachi, Akira Suto, Kotaro Suzuki, Koichi Hirose, Hiroshi Nakajima

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• Letters to the Editor

  • ·Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin

    Página :1368-1371

    Patrick L.J.M. Zeeuwen, Thomas H.A. Ederveen, Danique A. van der Krieken, Hanna Niehues, Jos Boekhorst, Sanja Kezic, Daniëlle A.T. Hanssen, Marisol E. Otero, Ivonne M.J.J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Denise Falcone, Ellen H.J. van den Bogaard, Marijke Kamsteeg, Heleen D. de Koning, Manon E.J. Zeeuwen-Franssen, Maurice A.M. van Steensel, Michiel Kleerebezem, Harro M. Timmerman, Sacha A.F.T. van Hijum, Joost Schalkwijk

      
  • ·Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis

    Página :1371

    Aden Lau, Susan Lester, Sophia Moraitis, Judy Ou, Alkis J. Psaltis, Shaun McColl, Maureen Rischmueller, Peter-John Wormald, Sarah Vreugde

     
  • ·Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide

    Página :1373

    Marina Miller, Peter Rosenthal, Andrew Beppu, Ruth Gordillo, David H. Broide

     
  • ·Prenatal phthalate exposure associates with low regulatory T-cell numbers and atopic dermatitis in early childhood: Results from the LINA mother-child study

    Página :1376

    Gunda Herberth, Arkadiusz Pierzchalski, Ralph Feltens, Mario Bauer, Stefan Röder, Sven Olek, Denise Hinz, Michael Borte, Martin von Bergen, Irina Lehmann, LINA Study Group

     
  • ·Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma

    Página :1379-1383

    Milena Sokolowska, Li-Yuan Chen, Yueqin Liu, Asuncion Martinez-Anton, Carolea Logun, Sara Alsaaty, Rosemarie A. Cuento, Rongman Cai, Junfeng Sun, Oswald Quehenberger, Aaron M. Armando, Edward A. Dennis, Stewart J. Levine, James H. Shelhamer

      
  • ·Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis

    Página :1383

    Kohei Hasegawa, Jonathan M. Mansbach, Nadim J. Ajami, Joseph F. Petrosino, Robert J. Freishtat, Stephen J. Teach, Pedro A. Piedra, Carlos A. Camargo

     
  • ·Association of ORAI1 gene polymorphisms with chronic spontaneous urticaria and the efficacy of the nonsedating H1 antihistamine desloratadine

    Página :1386

    Jie Li, Aiyuan Guo, Wangqing Chen, Lianghua Bin, Yijing He, Wu Zhu, Cong Peng, Siyu Yan, Mingliang Chen, Jianglin Zhang, Juan Su, Mei Yi, Zhaoqian Liu, Wei Zhang, Weiqi Zeng, Donald Y.M. Leung, Xiang Chen

     
  • ·Oral immunotherapy–induced gastrointestinal symptoms and peripheral blood eosinophil responses

    Página :1388

    Michael R. Goldberg, Arnon Elizur, Liat Nachshon, Michael Y. Appel, Michael B. Levy, Keren Golobov, Robert Goldberg, Miguel Stein, Marc E. Rothenberg, Yitzhak Katz

     
  • ·Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1

    Página :1391

    Emma M. Haapaniemi, Christopher L. Fogarty, Salla Keskitalo, Shintaro Katayama, Helena Vihinen, Mette Ilander, Satu Mustjoki, Kaarel Krjutškov, Markku Lehto, Timo Hautala, Ove Eriksson, Eija Jokitalo, Vidya Velagapudi, Markku Varjosalo, Mikko Seppänen, Juha Kere

     
  • ·Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens

    Página :1393

    Riikka Uotila, Anna Kaarina Kukkonen, Dario Greco, Anna Susanna Pelkonen, Mika Juhani Mäkelä

     
  • ·Tofacitinib relieves symptoms of stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173

    Página :1396

    Jieun Seo, Jung-Ah Kang, Dong In Suh, Eun-Byeol Park, Cho-Rong Lee, Sun Ah Choi, Soo Yeon Kim, Yeji Kim, Sang-Heon Park, Michael Ye, Soon-Hak Kwon, June Dong Park, Byung Chan Lim, Dong Hun Lee, Suk-Jo Kang, Murim Choi, Sung-Gyoo Park, Jong-Hee Chae

     
  • ·Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy

    Página :1399

    Ekaterina Avershina, Raul Cabrera Rubio, Krister Lundgård, Gaspar Perez Martinez, Maria Carmen Collado, Ola Storrø, Torbjørn Øien, Christian Kvikne Dotterud, Roar Johnsen, Knut Rudi

     

• Correspondence

  • ·Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors

    Página :1403

    Mrinmoy Das, Caroline Galeotti, Emmanuel Stephen-Victor, Anupama Karnam, Srini V. Kaveri, Jagadeesh Bayry

     
  • ·Reply

    Página :1405

    Oscar Palomares, José Luis Subiza

    
  • ·Early or delayed introduction of food? Misunderstanding is in the air

    Página :1405-1406

    Simona Di Mario, Vittorio Basevi, Costantino Panza, Sergio Conti Nibali, Adriano Cattaneo

    
  • ·Reply

    Página :1406-1407

    Jennifer Koplin, Katrina J. Allen

    
  • ·Reply

    Página :1407

    Mary Feeney, George Du Toit, Gideon Lack

    
  • ·The multimorbid polysensitized phenotype is associated with the severity of allergic diseases

    Página :1407-1408

    Jean Bousquet, Josep M. Anto, Jocelyne Just, Thomas Keil, Valérie Siroux, Magnus Wickman

    
  • ·Reply

    Página :1408-1409

    Andrew H. Liu, Edward M. Zoratti, Jacqueline A. Pongracic, Denise C. Babineau, Cynthia M. Visness, Peter J. Gergen, Alkis Togias, William W. Busse, Inner-City Asthma Consortium