Índice

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

    Página :2A

    
• • ·Table of Contents

    Página :5A

    
• • ·Editorial Board

    Página :22A

    

• Reader services

  • ·Information for Readers

    Página :29A

    
  • ·News & Notes

    Página :30A

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  • ·CME Activities Calendar

    Página :39A

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• News beyond our pages

  • ·News Beyond Our Pages

    Página :1501-1502

    Marc E. Rothenberg, Jean Bousquet

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• Reviews and feature articles

  • ·Patient-centered outcomes research to improve asthma outcomes

    Página :1503-1510

    Ayodola Anise, Romana Hasnain-Wynia

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  • ·Patient-centered outcomes research to improve asthma outcomes

    Página :1511

    
  • ·Using stakeholder engagement to develop a patient-centered pediatric asthma intervention

    Página :1512-1517

    Deborah Q. Shelef, Cynthia Rand, Randi Streisand, Ivor B. Horn, Kabir Yadav, Lisa Stewart, Naja Fousheé, Damian Waters, Stephen J. Teach

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  • ·Care transition interventions for children with asthma in the emergency department

    Página :1518-1525

    Molly A. Martin, Valerie G. Press, Sharmilee M. Nyenhuis, Jerry A. Krishnan, Kim Erwin, Giselle Mosnaim, Helen Margellos-Anast, S. Margaret Paik, Stacy Ignoffo, Michael McDermott, CHICAGO Plan Consortium

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  • ·Home visits are needed to address asthma health disparities in adults

    Página :1526-1530

    Tyra Bryant-Stephens, Shakira Reed-Wells, Maryori Canales, Luzmercy Perez, Marisa Rogers, A. Russell Localio, Andrea J. Apter

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  • ·Advances in clinical immunology in 2015

    Página :1531-1540

    Javier Chinen, Luigi D. Notarangelo, William T. Shearer

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  • ·Advances in food allergy in 2015

    Página :1541-1547

    Robert A. Wood

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  • ·Advances in atopic dermatitis in 2015

    Página :1548-1555

    Takashi Nomura, Kenji Kabashima

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  • ·Asthma in Puerto Ricans: Lessons from a high-risk population

    Página :1556-1558

    Sylvia E. Szentpetery, Erick Forno, Glorisa Canino, Juan C. Celedón

     

• The Editors' choice

  • ·The Editors' Choice

    Página :1559-1560

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze

    Página :1561

    Sze Man Tse, Sheryl L. Rifas-Shiman, Brent A. Coull, Augusto A. Litonjua, Emily Oken, Diane R. Gold

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  • ·Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

    Página :1571

    Ruzena Tkacova, Darlene L.Y. Dai, Judith M. Vonk, Janice M. Leung, Pieter S. Hiemstra, Maarten van den Berge, Lisette Kunz, Zsuzsanna Hollander, Donald Tashkin, Robert Wise, John Connett, Raymond Ng, Bruce McManus, S.F. Paul Man, Dirkje S. Postma, Don D. Sin

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  • ·Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden

    Página :1582-1590

    Matthew S. Perzanowski, Eva Ronmark, Hayley R. James, Linnea Hedman, Alexander J. Schuyler, Anders Bjerg, Bo Lundback, Thomas A.E. Platts-Mills

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  • ·A health care navigation tool assesses asthma self-management and health literacy

    Página :1593

    Luzmercy Perez, Knashawn H. Morales, Heather Klusaritz, Xiaoyan Han, Jingru Huang, Marisa Rogers, Ian M. Bennett, Cynthia S. Rand, Grace Ndicu, Andrea J. Apter

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  • ·Enrolling African-American and Latino patients with asthma in comparative effectiveness research: Lessons learned from 8 patient-centered studies

    Página :1600-1607

    C. Bradley Kramer, Lisa LeRoy, Sara Donahue, Andrea J. Apter, Tyra Bryant-Stephens, John P. Elder, Winifred J. Hamilton, Jerry A. Krishnan, Deborah Q. Shelef, James W. Stout, Kaharu Sumino, Stephen J. Teach, Alex D. Federman

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  • ·Individualized therapy for persistent asthma in young children

    Página :1608

    Anne M. Fitzpatrick, Daniel J. Jackson, David T. Mauger, Susan J. Boehmer, Wanda Phipatanakul, William J. Sheehan, James N. Moy, Ian M. Paul, Leonard B. Bacharier, Michael D. Cabana, Ronina Covar, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Jacqueline A. Pongracic, Avraham Beigelman, Sachin N. Baxi, Mindy Benson, Kathryn Blake, James F. Chmiel, Cori L. Daines, Michael O. Daines, Jonathan M. Gaffin, Deborah Ann Gentile, W. Adam Gower, Elliot Israel, Harsha Vardhan Kumar, Jason E. Lang, Stephen C. Lazarus, John J. Lima, Ngoc Ly, Jyothi Marbin, Wayne Morgan, Ross E. Myers, J. Tod Olin, Stephen P. Peters, Hengameh H. Raissy, Rachel G. Robison, Kristie Ross, Christine A. Sorkness, Shannon M. Thyne, Stanley J. Szefler, National Institutes of Health/National Heart, Lung, and Blood Institute AsthmaNet ‡

    Resumen Resumen Esquema Esquema  
  • ·Toll-like receptor 2–expressing macrophages are required and sufficient for rhinovirus-induced airway inflammation

    Página :1619-1630

    Mingyuan Han, Yutein Chung, Jun Young Hong, Charu Rajput, Jing Lei, Joanna L. Hinde, Qiang Chen, Steven P. Weng, J. Kelley Bentley, Marc B. Hershenson

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  • ·Wheezing disorders in children: Are girls and boys different?

    Página :1569-1570

    Deepti Deshpande, Wayne Morgan

    
  • ·Airway hyperresponsiveness and chronic obstructive pulmonary disease outcomes

    Página :1580-1581

    Donald W. Cockcroft, Sally Wenzel

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  • ·Dogs, cats, and asthma: Will we ever really know the true risks and benefits?

    Página :1591-1592

    Dennis R. Ownby, Christine Cole Johnson

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial

    Página :1631-1638

    Hendrik Nolte, David I. Bernstein, Harold S. Nelson, Jörg Kleine-Tebbe, Gordon L. Sussman, Dorthe Seitzberg, Dorte Rehm, Amarjot Kaur, Ziliang Li, Susan Lu

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• Atopic dermatitis and skin disease

  • ·Early-onset pediatric atopic dermatitis is T_H2 but also T_H17 polarized in skin

    Página :1639-1651

    Hitokazu Esaki, Patrick M. Brunner, Yael Renert-Yuval, Tali Czarnowicki, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Donald B. Johnson, Bruce Bauer, Judilyn Fuentes-Duculan, Xiuzhong Zheng, Xiangyu Peng, Yeriel D. Estrada, Hui Xu, Christina de Guzman Strong, Mayte Suárez-Fariñas, James G. Krueger, Amy S. Paller, Emma Guttman-Yassky

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• Food, drug, insect sting allergy, and anaphylaxis

  • ·Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

    Página :1652

    Odelya E. Pagovich, Bo Wang, Maria J. Chiuchiolo, Stephen M. Kaminsky, Dolan Sondhi, Clarisse L. Jose, Christina C. Price, Sarah F. Brooks, Jason G. Mezey, Ronald G. Crystal

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  • ·Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy

    Página :1663

    Marcel Frick, Jörg Fischer, Arthur Helbling, Franziska Ruëff, Dorothea Wieczorek, Markus Ollert, Wolfgang Pfützner, Sabine Müller, Johannes Huss-Marp, Britta Dorn, Tilo Biedermann, Jonas Lidholm, Gerta Ruecker, Frank Bantleon, Michaela Miehe, Edzard Spillner, Thilo Jakob

    Resumen Resumen Esquema Esquema  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase ? syndrome–like immunodeficiency

    Página :1672

    Yuki Tsujita, Kanako Mitsui-Sekinaka, Kohsuke Imai, Tzu-Wen Yeh, Noriko Mitsuiki, Takaki Asano, Hidenori Ohnishi, Zenichiro Kato, Yujin Sekinaka, Kiyotaka Zaha, Tamaki Kato, Tsubasa Okano, Takehiro Takashima, Kaoru Kobayashi, Mitsuaki Kimura, Tomoaki Kunitsu, Yoshihiro Maruo, Hirokazu Kanegane, Masatoshi Takagi, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Osamu Ohara, Satoshi Okada, Masao Kobayashi, Tomohiro Morio, Shigeaki Nonoyama

    Resumen Resumen Esquema Esquema  
  • ·X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene

    Página :1681

    Chantal Lagresle-Peyrou, Sonia Luce, Farid Ouchani, Tayebeh Shabi Soheili, Hanem Sadek, Myriam Chouteau, Amandine Durand, Isabelle Pic, Jacek Majewski, Chantal Brouzes, Nathalie Lambert, Armelle Bohineust, Els Verhoeyen, François-Loïc Cosset, Aude Magerus-Chatinet, Frédéric Rieux-Laucat, Virginie Gandemer, Delphine Monnier, Catherine Heijmans, Marielle van Gijn, Virgil A. Dalm, Nizar Mahlaoui, Jean-Louis Stephan, Capucine Picard, Anne Durandy, Sven Kracker, Claire Hivroz, Nada Jabado, Geneviève de Saint Basile, Alain Fischer, Marina Cavazzana, Isabelle André-Schmutz

    Resumen Resumen Esquema Esquema  

• Mechanisms of allergy and clinical immunology

  • ·Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers

    Página :1690-1700

    Christopher F. Rider, Masatsugu Yamamoto, Oliver P. Günther, Jeremy A. Hirota, Amrit Singh, Scott J. Tebbutt, Chris Carlsten

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• Letters to the Editor

  • ·The association of asthma, total IgE, and blood lead and cadmium levels

    Página :1701

    Sangshin Park, Eun-Hee Lee, Younglim Kho

     
  • ·Early-life ozone exposure associated with asthma without sensitization in Latino children

    Página :1703

    Katherine K. Nishimura, Kensho Iwanaga, Sam S. Oh, Maria Pino-Yanes, Celeste Eng, Anjeni Keswani, Lindsey A. Roth, Elizabeth A. Nguyen, Shannon M. Thyne, Harold J. Farber, Denise Serebrisky, Kelley Meade, Michael A. LeNoir, William Rodriguez-Cintron, Luisa N. Borrell, Kirsten Bibbins-Domingo, Fred Lurmann, ?aunak Sen, Jose R. Rodriguez-Santana, Emerita Brigino-Buenaventura, Pedro C. Avila, John R. Balmes, Rajesh Kumar, Esteban G. Burchard

    
  • ·Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO

    Página :1706

    Sofie E. Jørgensen, Pernille Bøttger, Emil Kofod-Olsen, Mette Holm, Nanna Mørk, Torben F. Ørntoft, Uffe B.S. Sørensen, Jens Magnus Bernth-Jensen, Troels Herlin, Jens Veirum, Carsten S. Larsen, Lars Østergaard, Rune Hartmann, Mette Christiansen, Trine H. Mogensen

     
  • ·Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence

    Página :1709

    Daniela Cerny, Duyen Huynh Thi Le, Trung Dinh The, Roland Zuest, Srinivasan KG, Sumathy Velumani, Chiea Chuen Khor, Lucia Mori, Cameron P. Simmons, Michael Poidinger, Francesca Zolezzi, Florent Ginhoux, Muzlifah Haniffa, Bridget Wills, Katja Fink

     
  • ·Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

    Página :1712-1715

    Thomas J. Povsic, Monica G. Lawrence, A. Michael Lincoff, Roxana Mehran, Christopher P. Rusconi, Steven L. Zelenkofske, Zhen Huang, Jeffrey Sailstad, Paul W. Armstrong, P. Gabriel Steg, Christoph Bode, Richard C. Becker, John H. Alexander, N. Franklin Adkinson, Arnold I. Levinson, REGULATE-PCI Investigators

      
  • ·Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study

    Página :1715

    Lujain H. Albenali, Simon Danby, Manar Moustafa, Kirsty Brown, John Chittock, Fiona Shackley, Michael J. Cork

     
  • ·Efficacy of omalizumab in patients with atopic dermatitis: A systematic review and meta-analysis

    Página :1719

    Hsiao-Han Wang, Yu-Chuan Li, Yu-Chen Huang

    
  • ·Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: Report of 2 siblings

    Página :1722

    Johannes Trück, Dominic F. Kelly, John M. Taylor, Anne Kathrin Kienzler, Tracy Lester, Anneke Seller, Andrew J. Pollard, Smita Y. Patel

     
  • ·Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity

    Página :1725

    Su Duan, Kerstin Wanke, Paulina Wawrzyniak, Yifan Meng, Jeannette I. Kast, Beate Rückert, Ana Rebane, Mu Xian, Carsten Bindslev-Jensen, Sigurd Broesby-Olsen, Ulrike Raap, Thomas Werfel, Mübeccel Akdis, Luo Zhang, Cezmi A. Akdis

     
  • ·Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody-binding patterns

    Página :1728-1730

    Christian S. Hansen, Martin Dufva, Katrine L. Bøgh, Eric Sullivan, Jigar Patel, Thomas Eiwegger, Zsolt Szépfalusi, Morten Nielsen, Anders Christiansen

      
  • ·A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

    Página :1730-1732

    Jeffrey M. Harris, Christopher R. Cabanski, Heleen Scheerens, Divya Samineni, Mary S. Bradley, Colette Cochran, Petra Staubach, Martin Metz, Gordon Sussman, Marcus Maurer

      
  • ·The use of asthma controller medications during pregnancy and the risk of gestational diabetes

    Página :1732

    Véronique Baribeau, Marie-France Beauchesne, Évelyne Rey, Amélie Forget, Lucie Blais

     
  • ·Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function

    Página :1733

    Yifang Gao, Peter D. Arkwright, Rachel Carter, Angelica Cazaly, Rebecca J. Harrison, Alexandra Mant, Andrew J. Cant, Stephan Gadola, Tim J. Elliott, Salim I. Khakoo, Anthony P. Williams

     
  • ·Air pollutant–mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway

    Página :1736

    Nyall R. London, Anuj Tharakan, Ana M. Rule, Andrew P. Lane, Shyam Biswal, Murugappan Ramanathan

     
  • ·Common peptide epitopes induce cross-reactivity in hypersensitivity pneumonitis serodiagnosis

    Página :1738

    Laurence Millon, Benedicte Rognon, Benoit Valot, Coralie Barrera, Anne Pauline Bellanger, Sandrine Roussel, Jean-Charles Dalphin, Michel Monod, Gabriel Reboux

     
  • ·Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut

    Página :1741

    Leticia Tordesillas, Adeeb H. Rahman, Boris M. Hartmann, Hugh A. Sampson, M. Cecilia Berin

     
  • ·Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

    Página :1744

    Gertjan J. Driessen, Hanna IJspeert, Marjolein Wentink, Helger G. Yntema, P. Martin van Hagen, Arthur van Strien, Giorgia Bucciol, Ozgur Cogulu, Margreet Trip, Willy Nillesen, Els A. Peeters, Ingrid Pico-Knijnenburg, Barbara H. Barendregt, Marta Rizzi, Jacques J. van Dongen, Necil Kutukculer, Mirjam van der Burg

     
  • ·Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma

    Página :1747

    Erik B. Hysinger, Jeffrey D. Roizen, Frank D. Mentch, Lyam Vazquez, John J. Connolly, Jonathan P. Bradfield, Berta Almoguera, Patrick M. Sleiman, Julian L. Allen, Michael A. Levine, Hakon Hakonarson

     
  • ·Probiotic supplementation has little effect on peripheral blood regulatory T cells

    Página :1749

    Nicholas P. West, Peggy L. Horn, David B. Pyne, Hilary S. Warren, Suzanne Asad, Amanda J. Cox, Sampo J. Lahtinen, Markus J. Lehtinen, Peter A. Fricker, Allan W. Cripps, Barbara Fazekas de St Groth

     
  • ·Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

    Página :1752-1755

    Marie-Louise Frémond, Mathieu Paul Rodero, Nadia Jeremiah, Alexandre Belot, Eric Jeziorski, Darragh Duffy, Didier Bessis, Guilhem Cros, Gillian I. Rice, Bruno Charbit, Anne Hulin, Nihel Khoudour, Consuelo Modesto Caballero, Christine Bodemer, Monique Fabre, Laureline Berteloot, Muriel Le Bourgeois, Philippe Reix, Thierry Walzer, Despina Moshous, Stéphane Blanche, Alain Fischer, Brigitte Bader-Meunier, Fréderic Rieux-Laucat, Yanick Joseph Crow, Bénédicte Neven