Acute combined poisoning with the new designer drug 4-methyl-N-ethyl-cathinone (4-MEC) and gammabutyrolactone (GBL): A case report with different analytical approaches for identification of some metabolites - 23/08/14
, David Boels b, Andreas G. Helfer c, Séverine Ferec a, Marie Bretaudeau-Deguigne b, Bénédicte Lelièvre a, Markus R. Meyer c, Hans H. Maurer cBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Summary |
Objective |
4-Methyl-N-ethylcathinone (4-MEC) is a novel designer drug of the β-keto amphetamine family. A case of a mixed poisoning by 4-MEC and gamma-butyrolactone (GBL) is described. Two and half hours after an injected 0.25–0.5g 4-MEC dose and thirty minutes after GBL ingestion, a 39-year-old man became unconscious and presented after admission to the hospital, transient apnea needing oxygenation and stimulation. After 30min, he woke up, but remained confused for 4hours. He was discharged 13hours later without particular symptoms. For confirmation of the poisoning, different analytical procedures such as HPLC-UV/DAD, GC-MS, UPLC-MS/MS, and LC-HR-MS/MS were applied. Blood and urine levels (8h after injection) were respectively 353μg/L and 100mg/L for 4-MEC and 300mg/L and 1000mg/L for gamma-hydroxybutyric acid. In urine, three metabolites (dihydro-, nor-, and nor-dihydro-4-MEC) could be identified for the first time and were similar to those described for other molecules of this class.
El texto completo de este artículo está disponible en PDF.Keywords : 4-MEC, Metabolites, HPLC-DAD, GC-MS, UPLC-MS/MS, LC-HR-MS/MS
Esquema
Vol 26 - N° 3
P. 119-127 - septembre 2014 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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