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Exercise Is Associated with a Reduced Incidence of Sleep-disordered Breathing - 07/04/12

Doi : 10.1016/j.amjmed.2011.11.025 
Karim M. Awad, MD a, , Atul Malhotra a, Jodi H. Barnet b, Stuart F. Quan a, c, Paul E. Peppard b
a Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 
b Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health—Madison, Madison, Wisconsin 
c Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson 

Requests for reprints should be addressed to Karim M. Awad, MD, Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Ave., Boston, MA 02115

Abstract

Background

The effect of exercise on sleep-disordered breathing is unknown. While diet and weight loss have been shown to reduce the severity of sleep-disordered breathing, it is unclear whether exercise has an independent effect.

Methods

A population-based longitudinal epidemiologic study of adults measured the association between exercise and incidence and severity of sleep-disordered breathing. Hours of weekly exercise were assessed by 2 mailed surveys (1988 and 2000). Sleep-disordered breathing was assessed by 18-channel in-laboratory polysomnography at baseline and at follow-up.

Results

Associations were modeled using linear and logistic regression, adjusting for body mass index, age, sex, and other covariates. Hours of exercise were associated with reduced incidence of mild (odds ratio 0.76, P=.011) and moderate (odds ratio 0.67, P=.002) sleep-disordered breathing. A decrease in exercise duration also was associated with worsening sleep-disordered breathing, as measured by the apnea-hypopnea index (β=2.368, P=.048). Adjustment for body mass index attenuated these effects.

Conclusions

Exercise is associated with a reduced incidence of mild and moderate sleep-disordered breathing, and decreasing exercise is associated with worsening of sleep-disordered breathing. The effect of exercise on sleep-disordered breathing appears to be largely, but perhaps not entirely, mediated by changes in body habitus.

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Keywords : Exercise, Sleep apnea


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 Funding: Supported by grants R01HL62252 and 1UL1RR025011 from the National Institutes of Health.
 Conflict of Interest: None.
 Authorship: All authors contributed to the conception, design, analysis, interpretation, and drafting of the manuscript for important intellectual content.


© 2012  Elsevier Inc. Reservados todos los derechos.
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