Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis: Long-term results - 20/03/12
Corresponding author. Tel.: +33 4 72 11 75 08; fax: +33 4 72 11 75 76.Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Summary |
Background |
The combination of ursodeoxycholic acid (UDCA) and vitamin E is a therapeutic option for nonalcoholic steatohepatitis (NASH) but randomized controlled studies have produced inconsistent results. The objective of this study was to report the long-term tolerability and efficacy of this combination in our ten-year single center experience.
Methods |
The study group included 101 adult patients with persistent elevation of serum aminotransferases (AST and ALT) and/or γ glutamyl-transferase (GGT), in whom a histological diagnosis of NASH was made from January 1998 to January 2009, and who were treated with a combination of UDCA with vitamin E.
Results |
Median body mass index (30kg/m2) remained unchanged during the study. UDCA and vitamin E were well tolerated (5% withdrawal for side effects). Mean serum AST, ALT and GGT levels (expressed as times of Upper Normal Limit) diminished significantly (1.39±0.74 to 0.78±0.34 for AST, 1.72±0.92 to 0.91±0.69 for AST and 3.25±2.85 to 1.30±1.30 for GGT). AST, ALT and GGT reached normal range in 80%, 70% and 65% of the patients, respectively. From the ten patients who had a second liver biopsy during follow-up, NAS score improved in seven, and worsened in one.
Conclusions |
The combination of UDCA with vitamin E significantly improves liver function tests in long-term and is very well tolerated.
El texto completo de este artículo está disponible en PDF.Abbreviations : ALT, AST, BMI, FFAs, GGT, NAFLD, NAS, NASH, UDCA
Esquema
Vol 36 - N° 2
P. 146-155 - avril 2012 Regresar al número
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