Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies - 24/12/11
Doi : 10.1016/j.jaci.2011.08.040
Marjan Kerkhof, MD, PhD a, 
, Denise Daley, PhD b, 
, Dirkje S. Postma, MD, PhD c, Julie E. Park, MMath b, Moira Chan Yeung, MD d, Alet H. Wijga, PhD e, Ulrike Gehring, PhD f, Johan C. de Jongste, MD, PhD g, Henriëtte A. Smit, PhD h, Bert Brunekreef, PhD f, h, Onno C.P. van Schayck, MD, PhD i, Allan Becker, MD j, k, Gerard H. Koppelman, MD, PhD l
, Denise Daley, PhD b, , Dirkje S. Postma, MD, PhD c, Julie E. Park, MMath b, Moira Chan Yeung, MD d, Alet H. Wijga, PhD e, Ulrike Gehring, PhD f, Johan C. de Jongste, MD, PhD g, Henriëtte A. Smit, PhD h, Bert Brunekreef, PhD f, h, Onno C.P. van Schayck, MD, PhD i, Allan Becker, MD j, k, Gerard H. Koppelman, MD, PhD l a Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
c Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
l Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
b Department of Medicine, St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
d Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada
e National Institute for Public Health and the Environment, Bilthoven, The Netherlands
f Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
g Department of Pediatrics, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands
h Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
i Care and Public Health Research Institute (Caphri), Maastricht University, The Netherlands
j Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
k Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
| The PIAMA study is supported by the Dutch Asthma Foundation (grants 3.4.01.26, 3.2.06.022, 37 3.4.09.081, and 3.2.10.085CO), the ZON-MW Netherlands Organization for Health Research and Development (grant 912-03-031), the Stichting Astmabestrijding, and the Ministry of the Environment. CAPPS was funded by the Canadian Institutes for Health Research; AllerGen NCE, Inc (the Allergy, Genes and Environment Network), a member of the Networks of the Centres of Excellence Canada program; and a grant from the BC Chapter of the Canadian Lung association (to D.D.). D.D. is the recipient of a Michael Smith Foundation for Health Research (MSFHR) Career Scholar Award and holds a Tier II Canadian Research Chair appointment. |
|
| Disclosure of potential conflict of interest: D. Daley receives research support from the AllerGen National Center of Excellence, the Canadian Institutes for Health Research, and the Canadian Lung Association of British Columbia. D. S. Postma has consultant arrangements with Nycomed, GlaxoSmithKline, and AstraZeneca. A. Becker receives research support from the Canadian Institutes for Health Research. G. H. Koppelman receives research support from the Netherlands Asthma Foundation and GlaxoSmithKline. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2011
American Academy of Allergy, Asthma & Immunology. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
Vol 129 - N° 1
P. 256-259 - janvier 2012 Regresar al número
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