Brachial Artery Flow-mediated Dilation in Patients with Tako-Tsubo Cardiomyopathy - 24/11/11
, Inna Vorobyeva, MD, Anna Lebedeva, Irina Urazovskaya, MD, PhD, Anna Kalinskaya, MD, Dmitriy Skrypnik, MD, PhD, Alexander Shpektor, MD, PhD
Requests for reprints should be addressed to Elena Vasilieva, MD, PhD, FESC, Department of Cardiology, Moscow State University of Medicine and Dentistry, Yauzskaya Street 11, Moscow 109240, RussiaAbstract |
Background |
Tako-Tsubo cardiomyopathy (TTC) is a heart syndrome associated with transient myocardial contractile dysfunction. The pathogenesis of TTC remains unclear. The purpose of this study was to investigate brachial artery flow-mediated dilation (FMD) in patients with TTC.
Methods |
The results of FMD tests of 4 women with TTC were compared with the results from 18 women with ST-elevation acute myocardial infarction (STEMI) and from 26 healthy female volunteers. FMD tests in all patients were performed within 24 hours of admission and again at 1-3 weeks as a follow-up.
Results |
The FMD levels were significantly lower at the acute phase in patients with TTC than in patients with STEMI and in healthy volunteers (P <.01). After 1-3 weeks, the FMD test results of patients with TTC had greatly increased, and no significant differences were found between these results and the results from patients with STEMI (P >.05). Also, there were no significant differences in the FMD test results between the group of patients with TTC and the group of healthy volunteers (P >.05).
Conclusions |
There is a pronounced and reversible endothelial dysfunction in patients with TTC, which can impair myocardial perfusion.
El texto completo de este artículo está disponible en PDF.Keywords : Acute myocardial infarction with ST elevation, Brachial artery flow-mediated dilation test, Endothelial dysfunction, Tako-Tsubo cardiomyopathy
Esquema
| Funding: None. |
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| Conflict of Interest: None. |
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| Authorship: We confirm that the listed authors have participated actively in the study and have seen and approved the submitted manuscript. |
Vol 124 - N° 12
P. 1176-1179 - décembre 2011 Regresar al número
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