Clinical significance antigen-specific IgG4 for the diagnosis of food allergy in atopic dermatitis : The comparison of serum antigen-specific IgE and IgG4 levels with the results of DBPCFC for milk and egg white - 25/08/11
Abstract |
Rationale |
Allergen-specific IgG4 has been known to have protective effects for allergy provocation as a blocking antibody. The clinical significance of food-specific IgG4 for food allergy provocation was investigated.
Methods |
A total of 68 atopic dermatitis patients were involved. The serum levels of food-specific IgE and IgG4 were measured by Pharmacia UniCAP and using allergy protein chip of Food BioTech APC. Double-blind placebo-controlled food challenges (DPBCFC) for milk and egg white were performed. The results of DBPCFC were compared the serum levels of allergen-specific IgE and IgG4.
Results |
The mean serum milk-specific IgE level of atopic dermatitis patients with milk allergy was lower than the level of those without milk allergy. Moreover, mean serum milk-specific IgG4 levels were also significantly low in atopic dermatitis patients with milk allergy than in those without milk allergy. The results showed also similar pattern in egg white.
Conclusions |
The measurement of serum allergen-specific-IgG4 levels as well as IgE may be necessary for the diagnosis of food allergy.
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Vol 113 - N° 2S
P. S318 - février 2004 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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