Preoperative chemoradiation for rectal cancer: results of multimodality management and analysis of prognostic factors - 22/08/11
Corresponding author. Tel.: +1-312-695-2534; fax: +1-312-695-1462.Abstract |
Background |
Our goals were to examine the impact of neoadjuvant chemoradiation for rectal cancer on surgical outcomes and to determine prognostic factors predicting improved survival.
Methods |
Retrospective cohort of 56 male and 44 female patients.
Results |
After preoperative chemoradiation, 73% of patients had sphincter-preserving surgery. The 5-year disease-free (DFS) and overall survival rates were 77% and 81%, respectively. Twenty-five percent of patients showed a complete pathologic response. T-level downstaging and pathologic T stage did not correlate with recurrence or survival rates. Pathologic nodal stage was associated with a significant difference in recurrence rates (N0 19%, N1 20%, and N2 75%, P = .038) and DFS (N0/N1 vs. N2, 79% vs. 25%, P = .002).
Conclusion |
Neoadjuvant chemoradiation resulted in a high rate of sphincter preservation. Complete pathologic responses after surgery were frequent and although pathologic T stage after surgery did not affect recurrence rates, pathologic nodal response was associated with improved recurrence and survival rates.
El texto completo de este artículo está disponible en PDF.Keywords : Neoadjuvant chemoradiation, Rectal cancer, Rectal surgery
Esquema
Vol 193 - N° 3
P. 389-394 - mars 2007 Regresar al número
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