Cancer of unknown primary origin: a decade of experience in a community-based hospital - 21/08/11
, Desarom Teso, M.D. a, Alpin Malkan, M.D. a, Stanley J. Dudrick, M.D., F.A.C.S. a, b, J. Alexander Palesty, M.D., F.A.C.S. a, c
Corresponding author. Tel.: +1-203-709-6315; fax: +1-203-709-6089.Abstract |
Background |
Cancer of unknown primary (CUP) origin is a very aggressive disease with a poor prognosis. Most of the literature reports of CUP are generated from tertiary cancer centers.
Methods |
A retrospective chart review of all patients with a diagnosis of CUP was performed between January 1995 and January 2005. Age, gender, diagnostic evaluation, histologic diagnosis, location of metastases, treatment, and survival were recorded.
Results |
Ninety-one patients met the inclusion criteria. The pathologic diagnoses included adenocarcinoma (42.8%), undifferentiated carcinoma (34.5%), squamous cell carcinoma (9.8%), neuroendocrine cancer (6.5%), sarcoma (3.2%), and nonspecific malignant neoplasm (3.2%). The overall mean survival was 9.2 months (95% confidence interval, 6.1–12.4 mo), and for squamous cell carcinoma was 26.9 months (standard error, 5.7; P = .007).
Conclusions |
CUP encompasses a variety of different pathologic entities with an overall dismal 5-year survival. Nonetheless, squamous cell and neuroendocrine CUP are associated with a significantly better early prognosis than the other malignancies.
El texto completo de este artículo está disponible en PDF.Keywords : Unknown primary cancer, Metastatic cancer, Prognosis, Survival
Esquema
Vol 194 - N° 6
P. 833-838 - décembre 2007 Regresar al número
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