African Americans at Risk for Increased Iron Stores or Liver Disease - 21/08/11
, Victor R. Gordeuk, MD a, Beverly M. Snively, PhD b, Laura Lovato, MS b, James C. Barton, MD c, Ronald T. Acton, PhD d, Gordon D. McLaren, MD e, Catherine Leiendecker-Foster, MS f, Christine E. McLaren, PhD g, Paul C. Adams, MD h, Mark Speechley, PhD h, Emily L. Harris, PhD i, Sharon Jackson, PhD b, Elizabeth J. Thomson, MS j
Requests for reprints should be addressed to Fitzroy W. Dawkins, MD, Oncology, Ortho Biotech, 430 Route 22 East, Bridgewater, NJ 08807-0914.Abstract |
Purpose |
We sought to determine the prevalence of elevated measures of iron status in African Americans and whether the combination of serum ferritin concentration >200 μg/L for women or >300 μg/L for men and transferrin saturation in the highest quartile represents increased likelihood of mutation of HFE, self-reported iron overload or self-reported liver disease.
Subjects and Methods |
A cross-sectional observational study of 27,224 African Americans ≥25 years of age recruited in a primary care setting was conducted as part of the multi-center, multi-ethnic Hemochromatosis and Iron Overload Screening (HEIRS) Study. Measurements included serum ferritin concentration, transferrin saturation, testing for HFE C282Y and H63D, and self-reported iron overload and liver disease.
Results |
Serum ferritin concentration >200 μg/L for women or >300 μg/L for men occurred in 5263 (19.3%) of African Americans, while serum ferritin concentration in this range with highest-quartile transferrin saturation (>29% women; >35% men) occurred in 1837 (6.7%). Adjusted odds of HFE mutation (1.76 women, 1.67 men), self-reported iron overload (1.97 women, 2.88 men), or self-reported liver disease (5.18 women, 3.73 men) were greater with elevated serum ferritin concentration and highest-quartile transferrin saturation than with nonelevated serum ferritin concentration (each P <.05).
Conclusions |
Serum ferritin concentration >200 μg/L for women or >300 μg/L for men in combination with transferrin saturation >29% for women or >35% for men occurs in approximately 7% of adult African American primary care patients. Patients with this combination of iron test results should be evaluated for increased body iron stores or liver disease.
El texto completo de este artículo está disponible en PDF.Keywords : African Americans, Serum ferritin, Transferrin saturation, HFE, Liver disease, Increased iron stores
Esquema
| The HEIRS Study was initiated and funded by NHLBI, in conjunction with NHGRI. The study is supported by contracts N01-HC-05185 (University of Minnesota), N01-HC-05186 (Howard University), N01-HC-05188 (University of Alabama at Birmingham), N01-HC-05189 (Kaiser Permanente Center for Health Research), N01-HC-05190 (University of California, Irvine), N01-HC-05191 (London Health Sciences Centre), and N01-HC-05192 (Wake Forest University). Additional support was provided by grant UH1-HL03679-07 from NHLBI and the Office of Minority Health, and by General Clinical Research Center (GCRC) grants to Howard University (M01-RR10284), University of California, Irvine (5M01RR 00827-29) and University of Alabama at Birmingham (M01-RR00032), sponsored by the National Center for Research Resources, National Institutes of Health (NCRR/NIH). |
Vol 120 - N° 8
P. 734.e1-734.e9 - août 2007 Regresar al número
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