Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats - 19/08/11
Corresponding author: Tel.: +86-23-63693532; fax: +86-23-63829191Abstract |
Background |
The effect of glutamine-enriched early enteral nutrition (Gln-EEN) on intestinal mucosal barrier injury after liver transplantation (LT) remains uncertain.
Methods |
The Wistar-to-Wistar rat LT model was used to explore the protective effect of Gln-EEN. Morphologic changes of intestinal mucosa, levels of intestinal malondialdehyde and secretory immunoglobulin (sIgA), plasma endotoxin, D-lactic acid, serum tumor necrosis factor-⍺ (TNF-⍺), rates of bacterial translocation, and expression of intestinal nuclear factor-κB, TNF-⍺, and intercellular adhesion molecule-1 were determined.
Results |
After LT, intestinal mucosa was damaged seriously. At 12, 24, and 48 hours posttransplantation, levels of intestinal sIgA were decreased; levels of malondialdehyde, endotoxin, D-lactic acid, and TNF-⍺, the ratio of bacterial translocation, and the expression of intestinal nuclear factor-κB, TNF-⍺, and intercellular adhesion molecule-1 all were increased. However, changes in earlier-mentioned parameters in recipients treated with Gln-EEN were attenuated remarkably at 24 to 48 hours.
Conclusions |
Our data show that Gln-EEN is a potent protectant against intestinal mucosal barrier injury after LT.
El texto completo de este artículo está disponible en PDF.Keywords : Glutamine, Enteral nutrition, Liver transplantation, Bacterial translocation, Mucosal barrier
Esquema
| The authors have no financial conflicts of interest. |
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| Y.L. and Y.C. contributed equally to this work. |
Vol 199 - N° 1
P. 35-42 - janvier 2010 Regresar al número
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